Comparison of the pharmacokinetics of sulfamethoxazole in male chinese volunteers at low altitude and acute exposure to high altitude versus subjects living chronically at high altitude: An open-label, controlled, prospective study

Li, Xiangyang; Gao, Fang; Li, Zhanquan; Guan, Wei; Feng, Weili; Ge, Ri-Li

doi:10.1016/j.clinthera.2009.11.019

Cited by 28 publications

(18 citation statements)

References 21 publications

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“…We may predict that the area under the concentration-time curve (AUC) for substrates of CYP1A2 and NAT2 will be bigger because of increased absorption and decreased first pass and renal clearance in the high-altitude hypoxic environment. Our previous study demonstrated that the AUC for sulfamethoxazole metabolized mainly by NAT2 was 17.8% greater and clearance was 17.8% lower in healthy Chinese male volunteers after 16 h of exposure to high altitude (3,780 m) compared with control volunteers residing at low altitude (400 m) [19]. For substrates of CYP2D6, hypoxia will reduce their AUC and increase their clearance.…”

Section: Discussionmentioning

confidence: 99%

“…The prevention and treatment of high-altitude illness [17,18] and pharmacokinetic changes of drugs such as sulfamethoxazole, lithium, acetazolamide and meperidine at high altitude have been studied [19,20,21]. These studies found significant changes in the disposition of drugs in healthy subjects after either acute or chronic exposure to high altitude.…”

Section: Introductionmentioning

confidence: 95%

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Effect of Exposure to Acute and Chronic High-Altitude Hypoxia on the Activity and Expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in Rats

Wang

et al. 2014

Pharmacology

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We investigated the effect of exposure to acute and chronic high-altitude hypoxia (AHH and CHH) on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats. The rats were divided into plain (400 m), acute middle-altitude hypoxia (2,800 m), chronic middle-altitude hypoxia (2,800 m), AHH (4,300 m) and CHH (4,300 m). After probe drugs had been orally administered to the rats of the 5 groups, the serum or urine concentration of the probe drug and its metabolite was determined by reversed-phase HPLC. The activity of cytochrome P450 isozyme and NAT2 was evaluated by the ratio of the metabolite to the probe drug. The ELISA and real-time PCR were used to analyze the protein and mRNA expression of cytochrome P450 isozyme and NAT2, respectively. AHH and CHH caused significant decreases in the activity and protein and mRNA expression of rat CYP1A2 in vivo. AHH downregulates the activity and mRNA expression of rat NAT2 in vivo, and CHH upregulates the activity and protein and mRNA expression of rat CYP2D6. AHH and CHH did not change the expression of CYP2C9 and CYP2C19 in rats. This study found significant changes in the activity and protein and mRNA expression of CYP1A2, CYP2D6 and NAT2 in rats in the special environment of high-altitude hypoxia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Effect of Exposure to Acute and Chronic High-Altitude Hypoxia on the Activity and Expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in Rats

Wang

et al. 2014

Pharmacology

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“…Sulfamethoxazole (SMX), an important broad-spectrum antibacterial with superior stability (Li et al 2009), is a complex nitrogencontaining heterocyclic compounds with a molecular formula of C 10 H 11 N 3 O 3 S. While a benefit in the clinic, the stability of SMX can be a problem when it is discharged into the aquatic environment because its residues may induce bacterial resistance and be an endocrine disruptor (Thiele-Bruhn and Beck 2005). Even though sulfonamides normally are detected at very low concentration in nature, aquatic organisms might experience deleterious effects due to a concentration build up in areas subject to decades of unregulated discharge (Nasuhoglu et al 2011;Akiyama and Savin 2010;Tao et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Internal loop photobiodegradation reactor (ILPBR) for accelerated degradation of sulfamethoxazole (SMX)

Yan

Xia

Lin-ke

et al. 2012

Appl Microbiol Biotechnol

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The internal loop photobiodegradation reactor (ILPBR) was evaluated for the degradation of the pharmaceutical sulfamethoxazole (SMX) using batch experiments following three protocols: photolysis alone (P), biodegradation alone (B), and intimately coupled photolysis and biodegradation (P&B). SMX was removed more rapidly by P&B than by either P or B alone, and the corresponding dissolved organic carbon (DOC) removals by P&B also were higher. The faster SMX removal probably was due to a synergy between photolysis and the rapid biodegradation of SMX by the biofilm. The greater DOC removal was brought about by the presence of biofilm bacteria able to biodegrade photolysis products. Ammonium N released during photolysis of SMX gave more evidence for the formation of intermediates and was enough in P&B experiments to support bioactivity when no other N was supplied. Clone libraries performed on the biofilms before and after the P&B experiments showed profound changes in the microbial community. Whereas Rhodopirellula baltica and Methylibium petroleiphilum PM1 dominated the biofilm after the B experiments, they were replaced by Micrococcus luteus, Delftia acidovorans, and Oligotropha carboxidovorans after the P&B experiments. The changes in microbial community structure mirrored the change in function in the P&B experiments: SMX biodegradation (presumably the roles of R. baltica and M. petroleiphilum) was out-competed by SMX photolysis, but biodegradation of photolysis products (most likely by M. luteus and D. acidovorans) became important. The higher removal rates of SMX and DOC, as well as the changes in microbial community structure, confirm the value of intimately coupling photolysis with biodegradation in the ILPBR.

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“…The prevention and treatment of high-altitude illness [9][10][11] and pharmacokinetic differences in the processing of drugs such as sulfamethoxazole, lithium, acetazolamide, meperidine, and prednisolone at high altitudes have been studied [12][13][14][15] . These studies found significant changes in the disposition of drugs in healthy subjects after both acute and chronic exposure to high altitude.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of Lidocaine Hydrochloride Metabolized by CYP3A4 in Chinese Han Volunteers Living at Low Altitude and in Native Han and Tibetan Chinese Volunteers Living at High Altitude

Zhang¹,

Zhu²,

Yao³

et al. 2016

Pharmacology

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To investigate the pharmacokinetics of lidocaine hydrochloride metabolized by cytochrome P450 3A4 (CYP3A4) in Chinese Han volunteers living at low altitude (LA) and in native Han and Tibetan Chinese volunteers living at high altitude, lidocaine hydrochloride 10 mg was given by intramuscular injection to 3 groups: Han volunteers living at LA, and native Han and Tibetan volunteers living at a high altitude. Blood samples were collected before the (baseline) study drug was given and at 0.25, 0.5, 1.0, 1.5, 2.0, 3.0, 4.0, 6.0, 8.0 h after study drug administration. Lidocaine hydrochloride in plasma was determined by RP-HPLC. Pharmacokinetics parameters of lidocaine hydrochloride showed that there were no significant difference between the native Han and Tibetan volunteers, but the t_1/2 was 29.8 and 29.8% higher in 2 groups, respectively, than in the LA group. To study related mechanism, the effects of exposure to chronic high-altitude hypoxia (CHH) on the activity and expression of CYP3A1 were examined in rats. Rats were divided into LA, chronic moderate altitude hypoxia, and CHH groups. CHH caused significant decreases in the activity and protein and mRNA expression of rat CYP3A1 in vivo. This study found significant changes in the disposition of lidocaine hydrochloride in native healthy Tibetan and Han Chinese subjects living at a high altitude in comparison to healthy Han Chinese subjects living at LA, it might be due to significant decreases in the activity and protein and mRNA expression of CYP3A4 under CHH condition.

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Comparison of the pharmacokinetics of sulfamethoxazole in male chinese volunteers at low altitude and acute exposure to high altitude versus subjects living chronically at high altitude: An open-label, controlled, prospective study

Cited by 28 publications

References 21 publications

Effect of Exposure to Acute and Chronic High-Altitude Hypoxia on the Activity and Expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in Rats

Effect of Exposure to Acute and Chronic High-Altitude Hypoxia on the Activity and Expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in Rats

Internal loop photobiodegradation reactor (ILPBR) for accelerated degradation of sulfamethoxazole (SMX)

Pharmacokinetics of Lidocaine Hydrochloride Metabolized by CYP3A4 in Chinese Han Volunteers Living at Low Altitude and in Native Han and Tibetan Chinese Volunteers Living at High Altitude

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