Comparison of the physicochemical properties of MCT-containing fat emulsions in total nutrient admixtures

Télessy, István G.; Balogh, J; Csempesz, Ferenc; Szente, Virág; Dredán, J.; Zelkó, Romána

doi:10.1016/j.colsurfb.2009.03.016

Cited by 11 publications

(7 citation statements)

References 10 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mixtures were made on basis of the prescription "No F37 regularly used at the Semmelweis University, Budapest and used in our previous studies [2]. Nine variations of all-in-one mix- tures (variations of pediatric prescription F37) were prepared for the experiment: TNA plus calcium and glucose enrichment in 3 concentrations each (Fig.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Stability assessment of o/w parenteral nutrition emulsions in the presence of high glucose and calcium concentrations

Télessy¹,

Balogh

Turmezei

et al. 2011

Journal of Pharmaceutical and Biomedical Analysis

Self Cite

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

“…Authors examined in their previous studies the kinetic stability of long chain triglycerides (LCT) vs. long and medium chain triglyceride (LCT-MCT) mixtures, later on the features of different forms of LCT-MCT mixtures (random lipids vs. structured lipids) in standard composition [1,2].…”

Section: Introductionmentioning

confidence: 99%

Stability assessment of o/w parenteral nutrition emulsions in the presence of high glucose and calcium concentrations

Télessy¹,

Balogh

Turmezei

et al. 2011

Journal of Pharmaceutical and Biomedical Analysis

Self Cite

View full text Add to dashboard Cite

“…Electrolytes adsorb on the surface of the lipid emulsion particles in a specific and nonspecific way, disturbing the stability of the oil-in-water system. Depending on the composition of PN admixtures, the zeta potential may have values approaching zero [23][24][25][26]. Such admixtures can be still stable for the specific time needed for their administration.…”

Section: Discussionmentioning

confidence: 99%

Safe Practice of Y-Site Drug Administration: The Case of Colistin and Parenteral Nutrition

et al. 2020

View full text Add to dashboard Cite

A serious problem in everyday clinical practice is the co-administration of drugs using the same infusion line. Potential complications of co-administration of incompatible drugs include precipitation in the infusion line or central venous catheter leading to its occlusion. Administration of precipitate and large lipid droplets into the venous system may lead to the embolization of capillaries and local or systemic inflammatory reactions, with the consequences of venous thrombosis, chronic venous insufficiency, and even pulmonary embolism. The co-administration of drugs must always be confirmed and clearly defined. The study aimed to determine the interaction between colistin (COL) in the dose used during intermittent hemodialysis and five different ready-to-use PN admixtures (PN) (Kabiven, Smofkabiven, Olimel N9E, Nutriflex Lipid Special, and Nutriflex Omega Special). COL-PN compatibilities were tested by comparing physicochemical properties (pH, zeta potential, lipid emulsion particle size) of COL and PN at three time points: immediately after sample preparation, after ten minutes, and after four hours. No changes in the visual inspection were observed. Both PN without COL and COL-PN samples remained white, homogeneous oil-in-water emulsions with no signs of phase separation, precipitation, or color change. There were no significant changes in pH, and the mean droplet diameter remained below the acceptance limit of 500 nm. The zeta potential and osmolality of COL-PN samples ranged from −21.4 to −7.22 mV and from 567 to 1304 mOsm/kg, respectively. The COL does not influence the physical stability of studied PN admixtures. The co-infusion of COL with Kabiven, Nutriflex Lipid Special, Olimel N9E, Nutriflex Omega Special, and Smofkabiven is possible in the dose used during intermittent hemodialysis.

show abstract

“…In our previous studies the droplet size stability of all-in-one nutritive mixtures containing different fat emulsions were studied. Authors concluded that droplet stability of MCT/LCT lipids surpassed the pure LCT [2] and the SMOF-lipid was more stable than that of MCT/LCT [3]. In our present study we broadened the range of lipids with olive-oil containing emulsion.…”

Section: Introductionmentioning

confidence: 91%

Kinetic stability of all-in-one parenteral nutrition admixtures in the presence of high dose Ca2+ additive under clinical application circumstances

Télessy¹,

Balogh

Szabó

et al. 2012

Nutr J

View full text Add to dashboard Cite

BackgroundTPN infusions are usually administered during a treatment period of 10–24 hours per day due to the metabolic capacity of the liver. During this time interval physicochemically stable TPN solution (emulsion) is needed for the treatment. The purpose of the present study was to examine how the kinetic stability features of ready-made total parenteral nutrition admixtures containing olive oil and soybean oil will change under the usage-modeling 24-hour application with and without overdose Ca2+.MethodsParticle size analysis and zeta potential measurements were carried out to evaluate the possible changes in the kinetic stability of the emulsions.ResultsOur results indicate that in two of the four mixtures bimodal droplet-size distribution figures were detected and appearance of fat particles over 5 μm can not be disclosed. The tendency for separation of large diameter droplets in the two types of oil-based emulsion systems was different. In case of soybean containing emulsion second peak of droplets appeared in the bottom of the container in contrast to the olive oil containing emulsions where the second peak appeared in the surface layer. Interestingly this phenomenon is independent of calcium-content.ConclusionsFrom therapeutic point the emulsions of the bigger droplets containing upper layer are safer because the potentially dangerous big droplets could remain in the infusion bag after the administration.

show abstract

Comparison of the physicochemical properties of MCT-containing fat emulsions in total nutrient admixtures

Cited by 11 publications

References 10 publications

Stability assessment of o/w parenteral nutrition emulsions in the presence of high glucose and calcium concentrations

Stability assessment of o/w parenteral nutrition emulsions in the presence of high glucose and calcium concentrations

Safe Practice of Y-Site Drug Administration: The Case of Colistin and Parenteral Nutrition

Kinetic stability of all-in-one parenteral nutrition admixtures in the presence of high dose Ca2+ additive under clinical application circumstances

Contact Info

Product

Resources

About