Comparison of the point of care test (POCT), i-CHROMA™ human chorionic gonadotrophin (HCG), leutinzing hormone (LH) and follicle stimulating hormone (FSH) methods with the other laboratory methods in the Randox International Quality Assessment Scheme (RIQAS)

Bolodeoku, John; Bains, Suman; Pinkney, S; Coker, Olu; Fakokunde, A.

doi:10.15761/cogrm.1000187

Cited by 11 publications

(11 citation statements)

References 12 publications

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“…The performance of the Boditech iCHROMA with EQA materials from organizations such as the United Kingdom National External Quality Assessment Service (UKNEQAS) and Randox International Quality Assessment Scheme (RIQAS) has been well described with analytes such as human chorionic gonadotrophin (HCG) [7], follicle stimulating hormone (FSH) [7], leutinising hormone (LH) [7], Vitamin D [8], Prostate Specific Antigen (PSA) [9], testosterone [10], ferritin [11]. The detection of SARS-CoV-2 infection is important in the understanding of this infection and the importance of the EQA in harmonizing the various methods of detecting the antibodies is appropriate.…”

Section: Discussionmentioning

confidence: 99%

Performance of the Boditech iCHROMA Covid-19 IgG antibody assay with the external quality control for UK NIBSC (National Institute of Biological Standards and Control)

Bolodeoku¹

2020

CMRR

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Background: There is a need for laboratories to participate in EQA schemes to achieve a harmonization of test results and to improve serological testing and research on COVID-19 and SARS-CoV-2. The Boditech iCHROMA point of care immunoassay analyser has a Covid-19 antibody assay for the qualitative determination of IgG antibodies in human whole blood/serum/plasma. The National Institute for Biological Standards and Control (NIBSC) in the United Kingdom has a portfolio of reference and research reagents, including reagents for EQA that are available to laboratories to help them set up and develop accurate diagnostic tests for SARS-CoV-2 assays. Objectives: To determine the performance of the Boditech iCHROMA Covid-19 IgG antibody assay using the external quality control material provided by the UK NIBSC (National Institute for Biological Standards and Control). Results: The Boditech iCHROMA Covid-19 IgG assay using the cut off index >1.1, reported the results of the 33 positive control samples as positive with index range from 19.50 – 29.00, with a mean of 23.75 and standard deviation of SD of 2.53. It also reported the results of the 33 negative control samples as negative with an index range of 0.00 for all samples. Conclusion: The performance of the Boditech iCHROMA Covid-19 IgG antibody assay using external quality control material from the UK NIBSC was very good, confirming the precision of the Boditech iCHROMA Covid 19 IgG antibody method.

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Section: Discussionmentioning

confidence: 99%

Performance of the Boditech iCHROMA Covid-19 IgG antibody assay with the external quality control for UK NIBSC (National Institute of Biological Standards and Control)

Bolodeoku¹

2020

CMRR

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“…Molecular tests are generally not suited for public health screening, antibody tests are more suited and the more portable, the better. A very versatile point of care immunoassay analyser, the Boditech iCHROMA™ has been shown to compare very well with traditional laboratory methods for PSA, Vitamin D, HCG, FSH, LH, TSH, Testosterone, CRP, Microalbumin and Ferritin [3][4][5][6][7][8][9][10]. Recently, Boditech launched a Fluorescence Immunoassay (FIA) for the qualitative determination of IgG/IgM antibodies against "Novel Coronavirus" in human whole blood, serum, and plasma.…”

Section: Introductionmentioning

confidence: 99%

Immune Checkpoint Inhibitors Therapy in Prostate Cancer: Lessons Learnt

Chandok¹

2020

AII

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Background:The Boditech iCHROMA™ point of care immunoassay analyser has a Covid-19 antibody assay for the qualitative determination of IgG/IgM antibodies in human whole blood/serum/plasma. It is helpful as an aid in the screening of early mild asymptomatic or acute patients for identifying Covid-19 infection with high sensitivity.Objectives: To determine the clinical agreement (sensitivity and specificity) of the Boditech iCHROMA™ Covid-19 antibody assay and the Abbott Architect SARS-CoV-2 IgG assay for the qualitative detection of IgG antibodies to SARS-CoV-2 in human serum and plasma.Results: Of the 50 plasma samples, 20 (40%) of the plasma samples assayed were reported as positive by both the Abbott Architect SARS-CoV-2 IgG assay and the Boditech iCHROMA™ Covid-19 IgG antibody assay. The remaining 30 (60%) of the plasma samples were reported as negative by Abbott Architect SARS-CoV-2 IgG antibody assay. However, the Boditech iCHROMA™ Covid-19 IgG antibody assay, reported only 27 of the 30 (90%) samples as negative. Conclusion:There was an overall agreement of 95%, with a sensitivity of 100% and a specificity of 90% of the Boditech iCHROMA™ Covid-19 IgG antibody assay and the Abbott Architect SARS-CoV-2 IgG assay.

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“…More recently, there have been a couple of point of care testing (POCT) methods for quantitatively estimating testosterone methods such as OPKO Claros and the Boditech i-CHROMA™ introduced into the market. We have extensively evaluated the comparative performance of the Boditech i-CHROMA™ for estimating Prostate Specific Antigen (PSA) [10][11][12], Vitamin D [13], Human Chorionic Gonadotrophin (HCG)14, Luteinizing Hormone (LH) [14], Follicle Stimulating Hormone (FSH) [14], C-Reactive Protein (CRP) [15], Microalbumin [15] and TSH [16] and found a very good correlation with other traditional laboratory methods. In this study, we set out to evaluate the performance of the Boditech i-CHROMA™ Testosterone method and compared it with a wide range of testosterone methods enrolled in the Randox International Quality Assessment Scheme (RIQAS) and the United Kingdom National External Quality Assessment Services (UKNEQAS).…”

Section: Introductionmentioning

confidence: 99%

The Accuracy Performance of the Point of Care Test (POCT) Boditech I-CHROMA™ Testosterone Method using External Quality Assessment Schemes: RIQAS and UKNEQAS

Bolodeoku¹,

Coker²,

Bains³

et al. 2019

AJBSR

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show abstract

Comparison of the point of care test (POCT), i-CHROMA™ human chorionic gonadotrophin (HCG), leutinzing hormone (LH) and follicle stimulating hormone (FSH) methods with the other laboratory methods in the Randox International Quality Assessment Scheme (RIQAS)

Cited by 11 publications

References 12 publications

Performance of the Boditech iCHROMA Covid-19 IgG antibody assay with the external quality control for UK NIBSC (National Institute of Biological Standards and Control)

Performance of the Boditech iCHROMA Covid-19 IgG antibody assay with the external quality control for UK NIBSC (National Institute of Biological Standards and Control)

Immune Checkpoint Inhibitors Therapy in Prostate Cancer: Lessons Learnt

The Accuracy Performance of the Point of Care Test (POCT) Boditech I-CHROMA™ Testosterone Method using External Quality Assessment Schemes: RIQAS and UKNEQAS

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