Comparison of the predictive characteristics of heart rate variability index and left ventricular ejection fraction for all-cause mortality, arrhythmic events and sudden death after acute myocardial infarction

Odemuyiwa, O; Malik, Marek; Farrell, T; Bashir, Yaver; Poloniecki, Jan; Camm, John

doi:10.1016/0002-9149(91)90774-f

Cited by 333 publications

(120 citation statements)

References 22 publications

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“…A decrease of HRV is a common finding in the elderly and in patients with heart disease, which has been demonstrated to be a predictor of an increased mortality in both populations (Odemuyiwa et al, 1991;Tsuji et al, 1996). However, in the long term cardiac autonomic imbalance may play a role in the development of cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Ambient fine particles modify heart rate variability in young healthy adults

Vallejo

Ruiz

Hermosillo

et al. 2005

J Expo Sci Environ Epidemiol

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Particulate air pollution has been related with cardiopulmonary morbidity and mortality. Recent studies have shown that an increase in particulate matter (PM) 2.5 ambient concentrations was associated with a decrease in heart rate variability (HRV) in the elderly with cardiovascular conditions, which could increase the risk of death. In order to assess if this association could also be observed in young adults, we studied 40 young healthy residents of the Mexico City Metropolitan Area (MCMA) who underwent 13 h Holter electrocardiographic and PM 2.5 personal monitoring. HRV was evaluated in time domain: the standard deviation of normal RR intervals (SDNN) and the percentage of differences between adjacent normal RR intervals larger than 50 ms (pNN50). In multivariate analysis with mixed effects models, a significant negative association of pNN50 with PM 2.5 accumulative exposure was found. An increase in 30 mg/m 3 of the average PM 2.5 personal exposure in the previous 2 h decreased the pNN50 in 0.08% (P ¼ 0.01). This observation revealed an acute effect related to environmental exposure to PM 2.5 with regard to HRV in normal youngsters. The long-term health consequences of this association in young healthy adults remain to be clarified.

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Section: Discussionmentioning

confidence: 99%

Ambient fine particles modify heart rate variability in young healthy adults

Vallejo

Ruiz

Hermosillo

et al. 2005

J Expo Sci Environ Epidemiol

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“…Myocyte apoptosis might also be responsible for heart failure after an MI 23 . Due to these facts, norepinephrine release by an increased sympathetic activity during ischemia or infarction has been linked to ventricular fibrillation, sustained ventricular tachycardia, and increased mortality 7,26,27 . On the other hand, increased vagal activity decreases the possibility of ventricular fibrillation 26 .…”

Section: (5) 2016 -343mentioning

confidence: 99%

Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats

Pasqualin

Mostarda²,

Souza³

et al. 2016

Acta Cir. Bras.

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PURPOSE:To investigate the myocardial ischemia-reperfusion with sevoflurane anesthetic preconditioning (APC) would present beneficial effects on autonomic and cardiac function indexes after the acute phase of a myocardial ischemia-reperfusion. METHODS:Twenty Wistar rats were allocated in three groups: control (CON, n=10), myocardial infarction with sevoflurane (SEV, n=5) and infarcted without sevoflurane (INF, n=5). Myocardial ischemia (60 min) and reperfusion were performed by temporary coronary occlusion. Twenty-one days later, the systolic and diastolic function were evaluated by echocardiography; spectral analysis of the systolic arterial pressure (SAPV) and heart rate variability (HRV) were assessed. After the recording period, the infarct size (IS) was evaluated. RESULTS:The INF group presented greater cardiac dysfunction and increased sympathetic modulation of the SAPV, as well as decreased alpha index and worse vagal modulation of the HRV. The SEV group exhibited attenuation of the systolic and diastolic dysfunction and preserved vagal modulation (square root of the mean squared differences of successive R-R intervals and high frequency) of HRV, as well as a smaller IS. CONCLUSION:Sevoflurane preconditioning better preserved the cardiac function and autonomic modulation of the heart in postacute myocardial infarction period.Key words: Autonomic Nervous System. Heart Rate. Myocardial Infarction. Ischemic Preconditioning, Myocardial. Rats. Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats

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“…The early concept that adrenergic hyperactivity could be deleterious has led to the widespread clinical use of beta-blockers in patients after AMI, with a consequent reduction in overall mortality (3). Decreased parasympathetic activity also represents an independent risk factor in post-AMI patients (4,5), but few studies have investigated the therapeutic options against parasympathetic dysfunction (6). Ventricular repolarization (expressed by the QTc interval on the electrocardiogram) is of prognostic importance when evaluating post-AMI patients (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Cholinergic stimulation with pyridostigmine reduces the QTc interval in coronary artery disease

Castro

Porphirio²,

Serra³

et al. 2002

Braz J Med Biol Res

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Parasympathetic dysfunction is an independent risk factor in patients with coronary artery disease; thus, cholinergic stimulation is a potential therapeutic measure that may be protective by acting on ventricular repolarization. The purpose of the present study was to determine the effects of pyridostigmine bromide (PYR), a reversible anticholinesterase agent, on the electrocardiographic variables, particularly QTc interval, in patients with stable coronary artery disease. In a randomized double-blind crossover placebo-controlled study, simultaneous 12-lead electrocardiographic tracings were obtained at rest from 10 patients with exercise-induced myocardial ischemia before and 2 h after the oral administration of 45 mg PYR or placebo. PYR increased the RR intervals (pre: 921 ± 27 ms vs post: 1127 ± 37 ms; P<0.01) and, in contrast with placebo, decreased the QTc interval (pre: 401 ± 3 ms vs post: 382 ± 3 ms; P<0.01). No other electrocardiographic variables were modified (PR segment, QT interval, QT and QTc dispersions). Cholinergic stimulation with PYR caused bradycardia and reduced the QTc interval without important side effects in patients with coronary disease. These effects, if confirmed in studies over longer periods of administration, may suggest a cardioprotection by cholinergic stimulation with PYR. Correspondence

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Comparison of the predictive characteristics of heart rate variability index and left ventricular ejection fraction for all-cause mortality, arrhythmic events and sudden death after acute myocardial infarction

Cited by 333 publications

References 22 publications

Ambient fine particles modify heart rate variability in young healthy adults

Ambient fine particles modify heart rate variability in young healthy adults

Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats

Cholinergic stimulation with pyridostigmine reduces the QTc interval in coronary artery disease

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