Comparison of the prognosis of bisphosphonate-related osteonecrosis of the jaw caused by oral and intravenous bisphosphonates

Bisphosphonate-related osteonecrosis of the jaws: Cohort study of surgical treatment results in seventy-four stage II/III patients

“…In contrast to some reports (Shintani et al, 2015), an association between the healing and the type of bisphosphonates, or the mode of administration (P = 0.157) could not be found. The results of the comparison between the two variables were the same.…”

Extensive Surgical Procedures Result in Better Treatment Outcomes for Bisphosphonate-Related Osteonecrosis of the Jaw in Patients With Osteoporosis

“…Since bisphosphonate-related osteonecrosis of the jaw (BRONJ) was first defined, 1,2 its greatest reported occurrence has been in oncology patients. [3][4][5][6][7][8] In addition to patients treated with highdosage intravenous administration of bisphosphonate, patients with osteoporosis who undergo treatment with oral bisphosphonate occupy a significant proportion of patients with BRONJ. 2,9,10 Prevention might be the most important aspect of this condition.…”

“…The purpose of the present study was to answer the following clinical questions: for BRONJ in patients with osteoporosis, 1) which type of surgical procedures would produce better treatment outcomes, and 2) whether a shorter period of bisphosphonate intake or a longer period of discontinuation (drug holiday) would show a better result. We hypothesized that 1) more extensive surgical procedures would result in better treatment outcomes for BRONJ in patients with osteoporosis; and 2) because the dose and type of bisphosphonate intake were believed to play a role in the initiation of BRONJ, 2,8,[22][23][24] patients who have had a shorter period of bisphosphonate intake and/or a longer period of discontinuation before surgery would have better results. The specific aims were to identify the risk factors associated with relapse or treatment failure after surgical treatment of BRONJ in patients with osteoporosis.…”

Delayed wound healing after tooth extraction and self-reported kyphosis in Japanese men and women

“…These facts may contribute to the recent rapid increase of ONJ cases in Japan (unpublished data). However, a study demonstrated that >90% of OP patients treated with oral BPs could be cured, whereas 50% of oncology patients treated with intravenous BPs did not show improvement17.…”