Comparison of the prognostic value of regadenoson and adenosine myocardial perfusion imaging

Abstract

SSS derived from either adenosine or regadenoson SPECT MPI is a significant predictor of events and provides incremental prognostic information beyond basic clinical variables. We have shown for the first time that use of regadenoson vs adenosine as stress agent does not modify the prognostic significance of SSS. Similar findings were seen with SDS.

Heart rate response to regadenoson: Making the case for its value in clinical practice

“…[1][2][3][4][5][6][7] It is, therefore, natural to pose the following questions, when reading about a novel prognostic indicator derived from regadenoson MPI 8 : Is there really a need for another risk predictor in patients undergoing regadenoson MPI? Will this novel predictor add value to the information that is already available to me?…”

The blood pressure response to vasodilator stress does not provide independent prognostic information

“…Vasodilator myocardial perfusion imaging (MPI) provides a large wealth of prognostic data that are related to the perfusion pattern [1][2][3][4] and to a vast array of nonperfusion variables as recently reviewed in the Journal. 5 This prognostic data are important for risk stratification and can help guide clinical management of patients.…”

Safety of stress testing in patients with elevated cardiac biomarkers: Are all modalities created equal?

“…A growing body of literature establishing the prognostic value of regadenoson radionuclide MPI as an equivalent to adenosine stress soon followed. [8][9][10][11] However, to date, there has not been a large study affirming the safety of regadenoson in post-MI patients or those with elevated cardiac troponin levels. The question can be asked: since they are similar in clinical utility, why cannot we extrapolate the safety profile of adenosine to regadenoson?…”