Comparison of the protective effects of papaverine, lidocaine and verapamil on the sperm quality of the testis after induced torsion–detorsion in rats

Shirazi, Mehdi; Noorafshan, Ali; Karbalay‐Doust, Saied; Ardeshiri, Mohammad; Afrasiabi, Mohammad Amin; Monabati, Ahmad

doi:10.3109/00365591003636588

Cited by 13 publications

(8 citation statements)

References 30 publications

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“…These detections can be related to a reduction in testosterone releasing by the Leydig cells and overproduction of ROS. Reported in several studies that ischaemia in the testis tissue for 4 hr led to declining in the sperm quality, such as concentration, the number of spermatozoa with normal morphology and motility (Sertkaya et al., ; Shirazi et al., ). In the present research, markers of oxidative stress, such as MDA, SOD and GPX, were measured due to their effects on biochemical and histological parameters.…”

Section: Discussionmentioning

confidence: 99%

“…Also, several studies show that the verapamil has antioxidant property. Therefore, it can protect the testis from I/R injury and improve the sperm quality related with I/R injury in testis tissue (Gao, Xuan, Wang, Sun, & Wang, ; Shirazi et al., ). In this study, we use a rat model to investigate the effect of tadalafil and verapamil and also combination of both drugs on testicular ischaemia–reperfusion injury.…”

Section: Introductionmentioning

confidence: 99%

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Protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion in adult male rat

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion in adult male rat

et al. 2018

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“…Common existing endogenous antioxidant enzymes include superoxide dismutase (SOD), catalase, and peroxidases[15,16]. Exogenous antioxidants include natural derived components such herb productions[17-25], vitamins[26-31], selenium[32], hormones[33-36], hormones receptors[37,38], vascular agents[39-41], phosphodiesterase inhibitors[42,43], anesthetic and non-steroid anti-inflammatory drugs[44-47], mucolytic agents[48], and hyperbaric oxygen[49]. All have been used in an effort to prevent the consequences of the oxidative stress in I/R injury.…”

Section: Introductionmentioning

confidence: 99%

Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?

Vaos

Zavras

2017

WJM

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Testicular torsion (TT) is a medical emergency that primary affects newborns and young adolescents. It causes testicular injury due to the torsion of the spermatic cord and its components, initially in the venous blood flow and finally in the arterial blood flow. Prompt diagnosis and early surgical management are necessary in managing this urgent situation. The process of the pathophysiological events in ischemia-reperfusion is multifactorial and deals with the perception of the oxidative stress responsible for the consequences of ischemia/reperfusion (I/R) stress following TT. Duration and severity of torsion also play a significant role in the oxidative stress. A detrimental result of the defense system of the testes takes place resulting finally in testicular atrophy and impaired function. Antioxidant factors have been experimentally studied in an effort to front this state. They have been classified as endogenous or exogenous antioxidants. Endogenous antioxidants comprise a structure of enzymic enzymatic and non-enzymic enzymatic particles presented within cytoplasm and numerous other subunits in the cells. Exogenous antioxidants include a variety of natural and pharmaceutical agents that may prevent or ameliorate the harmful effects of I/R injury. In this study we review those factors and their ability to enhance the oxidative status of the testis. A feature insight into where we are heading is attempted.

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“…In the revision of literature, it was found that only one study which has attempted to determine whether or not papaverine has a protective effect on I/R injury in the testes; 35 rats were separated into 5 groups (control, sham-operated, verapamil-treated, lidocaine-treated and papave-rine treated). In that study, papaverine did not show any protective effect in respect of sperm count, motility or morphology ( 26 ). In contrast, in the current study, the JTBS of the papaverine group was determined to be significantly higher than that of the T/D group.…”

Section: Discussionmentioning

confidence: 68%

The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury

et al. 2018

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Objective:To investigate the effect of papaverine and alprostadil on testicular torsion-detorsion injury in rats.Materials and Methods:A total of 40 male Wistar-Albino rats were used in this study. Four hours of right testicular torsion was applied to each group, excluding sham oper- ated group. The torsion-detorsion (T/D), T/D + papaverine and T/D + alprostadil groups received saline, papaverine and alprostadil at the same time as surgical detorsion, respectively. At 14 days after the surgical detorsion, ischaemic changes and the degree of damage were evaluated with Cosentino scoring and the Johnson tubular biopsy score (JTBS).Results:JTBS was determined as 8.8±2.7 in the Sham group, 5.08±1.9 in the T/D+papaverine group, 5.29±2.3 in the T/D +alprostadil group and 2.86±1.9 in the TD group. The JTBS was determined to be statistically significantly high in both the T/D + papaverine group and the T/D + alprostadil group compared to the T/D group (p=0.01, p=0.009). In the T/D + papaverine group, 3 (43%) testes were classified as Cosentino 2, 3 (43%) as Cosentino 3 and 1 (14%) as Cosentino 4. In the T/D +alprostadil group, 5 (50 %) testes were classified as Cosentino 2, 3 (30 %) as Cosentino 3 and 2 (20%) as Cosentino 4.Conclusion:The present study indicated that spermatic cord administration of alprostadil and papaverine showed a protective effect against ischemia/reperfusion injury after right-side testes torsion and histological changes were decreased after testicular ischemia reperfusion injury.

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Comparison of the protective effects of papaverine, lidocaine and verapamil on the sperm quality of the testis after induced torsion–detorsion in rats

Abstract: Verapamil can induce beneficial effects on semen analysis parameters after testicular torsion in rats.

Cited by 13 publications

References 30 publications

Protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion in adult male rat

Protective effect of tadalafil and verapamil on testicular function and oxidative stress after torsion/detorsion in adult male rat

Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?

The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury

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