Comparison of the QuantiFERON-TB Gold In-Tube test with the tuberculin skin test for detecting latent tuberculosis infection in hemodialysis patients

Abstract

QFT-G test results were more closely associated with TB risk factors than were positive TST results. Additionally, the QFT-G test was not affected by BCG vaccination. We concluded that QFT-G test is a more useful diagnostic method than TST for detecting LTBI in HD patients.

Evaluation of Gamma Interferon Immune Response Elicited by the Newly Constructed PstS-1(285-374):CFP10 Fusion Protein To Detect Mycobacterium tuberculosis Infection

“…In our particular setting, the worst correlations between TST and IGRAs were observed in BCG-vaccinated rCt for the tested antigens ( Յ 0.29; see Table S1 in the supplemental material). These data may suggest that the use of PPD leads to TST false-positive results in BCG-vaccinated individuals, which is in accordance with several studies demonstrating that TST positivity was significantly associated with prior BCG vaccination (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34), having odds ratios ranging from 3.8 (95% CI, 1.0 to 13.9) (32) to 24.7 (95% CI, 11.7 to 52.5) (34) in various epidemiological contexts. In contrast, the IGRA agreement between the 2 antigens in WBA ( ϭ 0.69 to 0.75) and LSA ( ϭ 0.48 to 0.50) was not significantly affected by vaccination status, demonstrating that the new constructed PstS-1(285-374):CFP10 fusion protein, as well as ESAT-6:CFP10, may not be cross-reactive with the BCG strains used in Brazil.…”

Diagnosing Latent Tuberculosis in Immunocompromised Patients Measuring Blood IP-10 Production Capacity: An Analysis of Chronic Renal Failure Patients

“…However, because the rate of positive results with the QFG-IT (or IP-10) test was also high among those who did not have any risk factors for LTBI (47.2% vs. 30.3%), good agreement was not obtained between the presence of LTBI risk factors and the test results. The IGRA-TST agreement in the diagnosis of LTBI is reportedly generally moderate (42,43), and our findings support this.…”

“…The same result has been obtained in CRF patients (41,42). Passalent et al reported that IGRA was positive in more than 70% of CRF patients with risk factors for LTBI, while TST gave positive results in roughly 20% (29).…”

Interferon-γ release assays for the diagnosis of latentMycobacterium tuberculosisinfection: a systematic review and meta-analysis

“…In nine of these, TST positivity was significantly associated with BCG vaccination as an independent predictor in multivariate analysis [47,50,55,62,67,71,72,74,77] with odd ratios ranging between 3.8 (95% CI 1.0-13.9) [50] [35] GOLETTI [36] JAFARI [37] JAFARI [38] KAMPMANN [39] KANG [40] LEE [41] MARKOVA [42] WANG [43] DETJEN [26] DHEDA [34] GOLETTI [36] KAMPMANN [39] KANG [40] MARKOVA [42] odds for test positivity with M. tuberculosis exposure gradients, or using chest radiography lesions as a surrogate of prior exposure, the IGRAs associated better with exposure than the TST, irrespective of the setting's disease burden. Furthermore, there was generally a poor agreement between IGRAs and TST results (for k statistics, see table 3).…”

“…Four studies were from intermediate-burden countries (South Korea [55], Lithuania [59], Iran [63] and Turkey [72]) and three studies were from high-burden countries (India [56], South Africa [61] and Vietnam [65]). Seven studies were based solely on paediatric cohorts [39,51,54,59,73,75] and three studies [47,57,61] included children in the study population.…”