Comparison of the Retention and Clearance of Different Welding Fumes in Rat Lungs

Kalliomäki, Pirkko-Liisa; Junttila, Marja-Leena; Kalliomäki, K.; Lakomaa, Eeva‐Liisa; Kivelä, Reijo

doi:10.1080/15298668391405652

Cited by 4 publications

(2 citation statements)

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“…Fe is the most abundant metal, followed by Zn and Mn in our study. Long-term exposure to iron dust can lead to siderosis with high levels of ferritin depositing in the lung [ 59 , 60 ]. Mn, a known neurotoxicant, would originate from the welding electrode and base metals and could act as a deoxidizing agent to increase the strength of the resultant weld [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Metal Exposure-Related Welder’s Pneumoconiosis and Lung Function: A Cross-Sectional Study in a Container Factory of China

Zhou

Wang

Chen

et al. 2022

IJERPH

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Long-term inhalation of welding fume at high exposure can cause welder’s pneumoconiosis, and metals in welding dust are associated with respiratory dysfunction. This cross-sectional study, which contains 384 Chinese male workers who were or had been working in a container factory, aimed to assess the potential risk of haemal and urinary metal content in welder’s pneumoconiosis. Further, we investigated their effects on lung function parameters. Metal content and lung function were measured using inductively coupled plasma–mass spectrometry (ICP-MS) and spirometer, respectively. The concentration and metal content of respirable dust as well as total dust were collected at this container factory. Lung function of cases with welder’s pneumoconiosis was significantly worse, as indicated by lower values of FVC, FVC% predicted, FEV1, FEV1% predicted, MEF25% predicted, and MMEF% predicted (p < 0.05). Results of logistic regression models showed that haemal Cr and Zn were risk factors of welder’s pneumoconiosis (OR = 4.98, 95%CI: 1.73–21.20, p = 0.009 for Cr; OR = 5.23, 95%CI: 1.56–41.08, p = 0.033 for Zn) after adjusted with age, BMI, working years, welding dust exposure years, and smoking status. Multiple linear regression models showed that several metals (haemal Cd and Pb; urinary Cd and Fe) were significantly associated with different lung function indices in the welder’s pneumoconiosis group. Compared to non-welders, welders were exposed to considerably higher levels of respirable dust, total dust, and six kinds of metals (p < 0.05). In conclusion, haemal Cr and Zn are positively related to welder’s pneumoconiosis. Meanwhile, Cd and Pb might worsen lung function in welder’s pneumoconiosis.

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Section: Discussionmentioning

confidence: 99%

Metal Exposure-Related Welder’s Pneumoconiosis and Lung Function: A Cross-Sectional Study in a Container Factory of China

Zhou

Wang

Chen

et al. 2022

IJERPH

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“…Fe has been shown to accumulate in the lungs of long-time welders and often causes a mostly benign lung condition known as siderosis. (10) Manganese (Mn), a known neurotoxicant, is a common component of most welding fumes as it improves metallurgical properties and acts as a deoxidizing agent to increase hardness and strength of the resultant weld. (11) Chromium (Cr) is common in SS welding fumes, existing in both Cr 3+ and Cr 6+ oxidation states.…”

Section: Welding Processes and Characterizationmentioning

confidence: 99%

Influence of welding fume metal composition on lung toxicity and tumor formation in experimental animal models

Zeidler-Erdely

Falcone

Antonini

2019

Journal of Occupational and Environmental Hygiene

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Millions of workers in the US and worldwide are exposed to complex, metal-rich welding fumes. Although welding is a crucial industrial process, the generated fumes are known to cause acute and chronic health effects when inhaled. The International Agency for Research on Cancer (IARC) classified welding fumes as carcinogenic to humans (Group 1) in 2017, based on sufficient epidemiological evidence and limited evidence in animals, an upgrade from the former Group 2B (possibly carcinogenic to humans) classification. There is human evidence that both iron-abundant mild steel as well as chromium- and nickel-containing stainless steel welding fumes contribute to an increased risk of lung cancer. Recent animal studies show that welding fumes may act as lung tumor promoters, regardless of the presence or absence of potentially carcinogenic metals, such as chromium and nickel. The goal of this manuscript was to examine the pulmonary responses associated with welding fumes by reviewing a series of recent experimental animal studies that assessed the influence of welding fume metal composition (e.g., stainless steel versus mild steel welding fume) on markers of lung toxicity and tumor development. Additional in vivo laboratory studies are needed to further explore the association between welding and lung cancer and to help advance our understanding of a potential mechanistic link.

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New weldable 316L stainless flux-cored wires with reduced Cr(VI) fume emissions: part 1—health aspects of particle composition and release of metals

et al. 2021

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Comparison of the Retention and Clearance of Different Welding Fumes in Rat Lungs

Cited by 4 publications

References 0 publications

Metal Exposure-Related Welder’s Pneumoconiosis and Lung Function: A Cross-Sectional Study in a Container Factory of China

Metal Exposure-Related Welder’s Pneumoconiosis and Lung Function: A Cross-Sectional Study in a Container Factory of China

Influence of welding fume metal composition on lung toxicity and tumor formation in experimental animal models

New weldable 316L stainless flux-cored wires with reduced Cr(VI) fume emissions: part 1—health aspects of particle composition and release of metals

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