Preventing oral flora and toxins from penetrating the root canal system and into the periapical tissues is the fundamental idea of successful root canal therapy. For this purpose, the entire root canal system, including the coronal and apical seals, must be obturated. Poor apical sealing allows bacteria to enter the root canal system and produce byproducts, or it allows tissue fluids to seep out, which can cause re-infection and endodontic treatment failure. Therefore, endodontic sealers are considered a cornerstone in the field of endodontics and are essential to the successful completion of root canal fills during obturation treatments. They resolve periapical inflammatory and/or infectious processes and prevent additional microbial contamination. A perfect endodontic sealer should have good adhesion to the canal walls, dimensional stability, insolubility against tissue fluids, sufficient setting time to guarantee working time and biocompatibility. Certain sealers, such as zinc-oxide-based, calcium hydroxide, glass ionomer, and resin, are clinically approved and frequently utilized, although no sealer possesses all of these qualities. Because of its decreased solubility, improved apical seal, microretention to root canal dentin, and decreased shrinkage, epoxy-resin-based sealers are utilized. Several research studies have demonstrated encouraging characteristics, particularly biocompatibility, antimicrobial qualities, and certain bioactivity of calcium-silicate based sealers. Zinc oxide eugenol sealer continues to be the most widely used sealer in many regions of the world.