Comparison of the Severity of Normal-Tension Glaucoma in Men and Women

Orgül, Selim; Gaspar, Ana Zulema; Hendrickson, Phillip

doi:10.1159/000310471

Cited by 12 publications

(4 citation statements)

References 6 publications

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“…1999), which are the main sources of blood supply for the ONH. This may in part explain the coincidence of a disposition to vasospastic reactivity in patients with NTG (Gasser & Flammer 1991; Orgül et al. 1994).…”

Section: Endothelial Dysfunction In Glaucomamentioning

confidence: 98%

Endothelial dysfunction in glaucoma

Resch

Garhöfer

Fuchsjäger-Mayrl

et al. 2009

Acta Ophthalmologica

187

123

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ABSTRACT.Glaucoma is a group of ocular diseases characterized by optic neuropathy associated with loss of the retinal nerve fibre layer and re-modelling of the optic nerve head, and a subsequent particular pattern of visual field loss. Increased intraocular pressure is the most important risk factor for the disease, but the pathogenesis of glaucoma is not monofactorial. Among other factors, ischaemia and vascular dysregulation have been implicated in the mechanisms underlying glaucoma. The vascular endothelium plays an important role in the regulation of ocular blood flow and pathological alterations of vascular endothelial cells may induce ischaemia and dysregulation. The present review summarizes our current evidence of endothelial dysfunction in glaucoma. This is of interest because endothelial dysfunction is a good prognostic factor for progression in several diseases. Although such data are lacking for glaucoma, endothelial dysfunction may provide an attractive target for therapeutic intervention in open-angle glaucoma and other vascular disorders of the eye.

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Section: Endothelial Dysfunction In Glaucomamentioning

confidence: 98%

Endothelial dysfunction in glaucoma

Resch

Garhöfer

Fuchsjäger-Mayrl

et al. 2009

Acta Ophthalmologica

187

123

View full text Add to dashboard Cite

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“…This syndrome is found more frequently in women than men (Flammer and Prunte 1991), which possibly correlates with the observation that normal tension glaucoma (NTG) is twice as common in women. Furthermore, the female gender is considered an independent risk factor for visual fi eld loss progression in NTG (Orgul et al 1994;Drance et al 2001). The increased susceptibility in females may be due to falling estrogen levels, which are known to have a vasoprotective effect and are reduced post-menopause (Siesky et al 2008).…”

Section: Vasospasmmentioning

confidence: 99%

Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?

Moore

Harris²,

WuDunn³

et al. 2008

OPTH

100

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Primary open angle glaucoma (OAG) is a multifactorial optic neuropathy characterized by progressive retinal ganglion cell death and associated visual fi eld loss. OAG is an emerging disease with increasing costs and negative outcomes, yet its fundamental pathophysiology remains largely undetermined. A major treatable risk factor for glaucoma is elevated intraocular pressure (IOP). Despite the medical lowering of IOP, however, some glaucoma patients continue to experience disease progression and subsequent irreversible vision loss. The scientifi c community continues to accrue evidence suggesting that alterations in ocular blood fl ow play a prominent role in OAG disease processes. This article develops the thesis that dysfunctional regulation of ocular blood fl ow may contribute to glaucomatous optic neuropathy. Evidence suggests that impaired vascular autoregulation renders the optic nerve head susceptible to decreases in ocular perfusion pressure, increases in IOP, and/or increased local metabolic demands. Ischemic damage, which likely contributes to further impairment in autoregulation, results in changes to the optic nerve head consistent with glaucoma. Included in this review are discussions of conditions thought to contribute to vascular regulatory dysfunction in OAG, including atherosclerosis, vasospasm, and endothelial dysfunction.

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“… 3–6 Caring for loved ones with vision loss is burdensome and often leaves the caregiver exhausted and at risk of health problems. 5 7 8 A UK study 9 showed an elevated level of caregiver burden associated with caring for family with wet AMD, which was equivalent to the burden experienced by caregivers of patients with rheumatoid arthritis and multiple sclerosis, 10 11 and higher than for patients with colorectal cancer. 9 …”

Section: Introductionmentioning

confidence: 99%

Implementing a multi-modal support service model for the family caregivers of persons with age-related macular degeneration: a study protocol for a randomised controlled trial

et al. 2017

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IntroductionAge-related macular degeneration (AMD) is a leading cause of blindness and low vision among older adults. Previous research shows a high prevalence of distress and disruption to the lifestyle of family caregivers of persons with late AMD. This supports existing evidence that caregivers are ‘hidden patients’ at risk of poor health outcomes. There is ample scope for improving the support available to caregivers, and further research should be undertaken into developing services that are tailored to the requirements of family caregivers of persons with AMD. This study aims to implement and evaluate an innovative, multi-modal support service programme that aims to empower family caregivers by improving their coping strategies, enhancing hopeful feelings such as self-efficacy and helping them make the most of available sources of social and financial support.Methods and analysisA randomised controlled trial consisting of 360 caregiver–patient pairs (180 in each of the intervention and wait-list control groups). The intervention group will receive the following: (1) mail-delivered cognitive behavioural therapy designed to improve psychological adjustment and adaptive coping skills; (2) telephone-delivered group counselling sessions allowing caregivers to explore the impacts of caring and share their experiences; and (3) education on available community services/resources, financial benefits and respite services. The cognitive behavioural therapy embedded in this programme is the best evaluated and widely used psychosocial intervention. The primary outcome is a reduction in caregiver burden. Secondary outcomes include improvements in caregiver mental well-being, quality of life, fatigue and self-efficacy. Economic analysis will inform whether this intervention is cost-effective and if it is feasible to roll out this service on a larger scale.Ethics and disseminationThe study was approved by the University of Sydney human research ethics committee. Study findings will be disseminated via presentations at national/international conferences and peer-reviewed journal articles.Trial registration numberThe trial registration number is ACTRN12616001461482; pre-results.

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Comparison of the Severity of Normal-Tension Glaucoma in Men and Women

Cited by 12 publications

References 6 publications

Endothelial dysfunction in glaucoma

Endothelial dysfunction in glaucoma

Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?

Implementing a multi-modal support service model for the family caregivers of persons with age-related macular degeneration: a study protocol for a randomised controlled trial

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