Comparison of the teratogenic potential of inhaled ethylene glycol monomethyl ether in rats, mice, and rabbits

Hanley, Thomas R.; Yano, Barry L.; Nitschke, K.D.; John, J.A.

doi:10.1016/0041-008x(84)90178-9

Cited by 73 publications

(23 citation statements)

References 17 publications

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“…Teratogenic effects were also seen in rabbits which were exposed to a 2-methoxyethanol concentration of 50 ml/m 3 for 6 hours daily from day 6 to day 18 of gestation [32]. The treatment interrupted temporarily body weight development of the dams; 63 % of the pups which were examined had at least one malformation, predominantly cardiac, urogenital and skeletal malformations.…”

Section: Teratogenic Effectsmentioning

confidence: 86%

2‐Methoxyethanol [MAK Value Documentation, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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Published in the series Occupational Toxicants , Vol. 6 (1993) The article contains sections titled: Toxic Effects and Modes of Action Effects in Man Effects on Animals Acute toxicity Effects on the central nervous system Effects on the blood Effects on the testes Teratogenic effects Genotoxicity and Cytotoxicity Manifesto (MAK value, classification)

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Section: Teratogenic Effectsmentioning

confidence: 86%

2‐Methoxyethanol [MAK Value Documentation, 1993]

2012

The MAK‐Collection for Occupational Health and Safety

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“…However, in the aggregate, studies of diverse occupational groups suggest that heavy metals, solvents (or specific agents that would fall into this category), and pesticides, may cause malformations in several organ systems. Yes (monkeys, rats, mice, rabbits) Yes (rats, mice, rabbits) Yes (monkeys, rats, mice, rabbits) Horton et al 1985;Nagano et al 1981;Greene et al 1987;Hanley et al 1984aHanley et al , 1984cNelson et al 1984a;Wickramaratne 1986;Feuston et al 1990;Scott et al 1989;Schuler et al 1984;NIOSH 1983 EGdiME (dimethyl) Yes (rats, mice)…”

Section: Established and Suspected Causesmentioning

confidence: 98%

Occupational exposure to glycol ethers and human congenital malformations

Maldonado

Delzell

Tyl³

et al. 2003

International Archives of Occupational and Environmental Health

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“…Laboratory animals (rats, mice, rabbits, guinea pigs, and hamsters) exposed to EGME have exhibited hematological, bone marrow, and lymphoid tissue disorders; atrophy of the testis with degeneration of the germinal epithelium; and infertility (1)(2)(3)(4)(5)(6)(7). The teratogenicity of EGME was first reported in rats, mice, and rabbits by Nagano et a1 (8) and has been further elucidated by Hanley et a1 (9). Similar hematologic, testicular, and teratogenic effects have been reported following exposure to EGEE (4,8,(10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 93%

Methoxyacetic acid and ethoxyacetic acid inhibit mitochondrial function in vitro

Beattie

Brabec

1986

J. Biochem. Toxicol.

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Ethylene glycol monomethyl ether (EGME) and ethylene glycol monoethyl ether (EGEE) have recently been shown to be potent reproductive toxicants in laboratory animals. The toxicity of these compounds is believed to be due to their metabolites, methoxyacetic acid (MAA) and ethoxyacetic acid (EAA). Since the primary targets of EGME and EGEE appear to be tissues with rapidly dividing cell systems and high rates of respiration and energy metabolism, the effects of these compounds and their proposed metabolites on mitochondria were investigated. At concentrations beginning at 3.85 mM, MAA and EAA inhibited state 3 respiration and the respiratory control ratio (RCR) in hepatic mitochondria with either succinate or citrate/malate as substrates. Cytochrome c oxidase activity was also inhibited by both metabolites at similar concentrations. The effects of MAA, the metabolite from the more potent compound, on testicular mitochondria were found to be comparable. Neither EGME or EGEE appeared to affect mitochondrial function at concentrations as high as 238 or 113 mM, respectively. These results support the hypothesis that the toxicity of EGME and EGEE are due to their metabolites, MAA and EAA, and that these metabolites may exert their effects, in part, on mitochondrial function.

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Comparison of the teratogenic potential of inhaled ethylene glycol monomethyl ether in rats, mice, and rabbits

Cited by 73 publications

References 17 publications

2‐Methoxyethanol [MAK Value Documentation, 1993]

2‐Methoxyethanol [MAK Value Documentation, 1993]

Occupational exposure to glycol ethers and human congenital malformations

Methoxyacetic acid and ethoxyacetic acid inhibit mitochondrial function in vitro

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