Comparison of the transcutaneous bilirubinometers BiliCheck and Minolta JM‐103 in preterm neonates

Ebbesen, Finn; Vandborg, Pernille Kure; Trydal, Torleif

doi:10.1111/j.1651-2227.2012.02797.x

Cited by 19 publications

(14 citation statements)

References 25 publications

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“…Pearson’s correlation coefficient obtained with Bilistick (r = 0.961) was higher than those reported for any transcutaneous POC instrument that ranged from 0.70 to 0.87 [13,14,15,16,17,18,19,20,21]. The Bland-Altman analysis showed a mean difference between hospital laboratory results and Bilistick determinations of 10.3 µmol/l and a 95% confidence interval of –38.0 to –58.7 µmol/l.…”

Section: Discussionmentioning

confidence: 89%

Bilistick: A Low-Cost Point-of-Care System to Measure Total Plasma Bilirubin

et al. 2012

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Background: Severe neonatal hyperbilirubinemia, with consequent encephalopathy, remains a common cause of morbidity and death in many regions of the world. Poor access to clinical laboratory resources and screening programs to measure plasma bilirubin levels is a major contributor to delayed treatment in developing countries, and the cost of existing point-of-care screening instruments precludes their dissemination. Objectives: We are evaluating the accuracy of a low-cost, minimally invasive point-of-care system (Bilistick) requiring a 25-µl blood sample that could be used in low-resource environments to evaluate patients with neonatal jaundice. Methods: We compared plasma bilirubin levels in divided blood samples by clinical laboratories and by Bilistick at two medical centers serving term and near-term newborns from ethnically different populations. Results: 118 neonates with bilirubin levels ranging from 24.8 to 501.0 µmol/l were analyzed. The mean bilirubin concentration (±SD) was 215.6 ± 85.5 µmol/l for Bilistick and 226.1 ± 86.4 µmol/l by laboratory determination. Pearson’s correlation coefficient between all paired results was 0.961, and the Bland-Altman analysis showed a mean difference of 10.3 µmol/l with a 95% interval of agreement of –38.0 to 58.7 µmol/l. Conclusion: Bilistick is a minimally invasive method for measuring total bilirubin concentration over a wide range of values and should provide an affordable and accurate system for pre-discharge and follow-up screening of jaundiced infants, particularly in low-resource environments.

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Section: Discussionmentioning

confidence: 89%

Bilistick: A Low-Cost Point-of-Care System to Measure Total Plasma Bilirubin

et al. 2012

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“…Depending on the device and target populations, TcB may either overestimate or underestimate bilirubin level in jaundiced neonates. 12,14,15 TcB screening in early hours of life may be a useful marker to foretell the possibility of hyperbilirubinemia in later days of life. 12,[16][17][18][19] In the present study, we showed that TSB and sternum TcB levels were plausibly correlated with each other in full term and near term infants with hyperbilirubinemia.…”

Section: Discussionmentioning

confidence: 99%

Transcutaneous Bilirubin Assessment for Screening of Hyperbilirubinemia in Term and Near-Term Neonates with Jaundice, a Comparative Study

Kalvandi¹,

Shahramian²,

Delaramnasab³

et al. 2017

Int J Basic Sci Med

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Introduction: Hyperbilirubinemia is a common condition in neonates. In this study, we aimed to investigate the association of total serum bilirubin (TSB) with sternum transcutaneous bilirubin (TcB) level obtained by KJ-8000 Transcutaneous bilirubin meter (KEJIAN medical apparatus). Methods: Eighty newborns were enrolled in the present prospective cross-sectional study. At first, blood sampling was performed for determination of TSB, and immediately after that, TcB levels were recorded at the sternum skin by KJ-8000 device. Data was analyzed by statistical software SPSS version 21.0. Results: The mean gestational age of the infants was 38.2 ± 1.5 weeks. The mean level of TSB was 13.52 ± 4 mg/dL, while the mean value of TcB was 13.71 ± 3.53 mg/dL. Pearson correlation analysis showed a correlation coefficient of r = 0.770 between sternum TcB recorded by KJ-8000 device and TSB. Conclusion: Given a strong correlation between TcB and TSB levels, it is advised the transcutaneous bilirubinometery be considered as the screening method in infant jaundice.

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“…On the other hand, there are controversies between the various studies about the value and use of BiliChek in premature infants. Ebbesen et al (2012) found that BiliChek is suitable for screening in both NICU and healthy newborn infants with jaundice, with regarding the need for phototherapy (6), and Willems et al (2004) showed that the BiliChek application in the NICU environment has the potential to reduce the number of blood samples taken by 40% (7). However, several studies have provided results for correlation coefficients between TCB and TSB, and the pooled estimates, according to the site of measurement, were 0.35 -0.65 with 95% confidence interval.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Diagnostic Value of Skin Bilirubin in Comparison with Plasma Bilirubin to Identify Hyperbilirubinemia in Healthy Babies

Danaei

lotfpour

Ghorbani

et al. 2016

Middle East J Rehabil Health

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Background: An elevated level of bilirubin in the blood is the most common and benign problem among newborns; it is also the most important factor in the evaluation of neonatal jaundice in newborns. If severe indirect hyperbilirubinemia is left untreated, it can be neurotoxic; therefore, doctors cannot overstate the need for the early detection of hyperbilirubinemia. Objectives: We investigated the relationship between the skin and plasma methods of the quality of the BiliChek process as a means of diagnosing hyperbilirubinemia Patients and Methods: This study was performed at Amiralmomenin hospital in Semnan, Iran and examined 64 healthy infants who had gestational ages of 37 weeks and greater and jaundice as their sole cause for hospitalization. Infants hospitalized due to other diseases, such as sepsis, were excluded from the study. First, a blood sample was taken to determine the infants' serum total bilirubin. Then, the amount of bilirubin was determined with BiliChek placed on three locations: the infants' foreheads, chests, and left thighs. Results: SD ± mean values of the skin method on each forehead, chest, and thigh were respectively (3.5 ± 13.8, 12.8 ± 3.5 and 9.7 ± 2.6 mg per deciliter); using the plasma method, bilirubin SD ± mean was 14.4 ± 4.0, so that the skin method in all three areas was lower than the plasma method. Variables such as the type of delivery, birth rank, blood type, birth weight, and maternal age are independent of hyperbilirubinemia level, and there is no significant relationship between them. There is only a significant relationship between bilirubin levels and a baby's age, as there is a significant relationship to birth (P = 0.000). Cut off point for the use of BiliChek in the forehead has been set at 3.13 milligrams per deciliter, and the sensitivity and specificity levels are 83.87% and 92.59%, respectively. As for the chest, it was 3.13 mg dL, with sensitivity and specificity levels of 83.87% and 96.30%, respectively. For the thigh, it was 9.7 mg per dL, with sensitivity and specificity levels of 83.87% and 96.30% respectively. There is no significant difference between the three areas mentioned in the skin method for predicting hyperbilirubinemia. Conclusions: In our study, we determined that BiliChek can be used in the diagnosis of hyperbilirubinemia, but this use is limited and applies only to the cutoff point and for values higher than the cutoff point. BiliChek is used as a means of screening for infants that need blood sampling.

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Comparison of the transcutaneous bilirubinometers BiliCheck and Minolta JM‐103 in preterm neonates

Abstract: TcB determined with JM-103 gave values much lower than those obtained with BiliCheck. The underestimation of TsB increased with increasing concentrations. By using transcutaneous bilirubinometers in preterm neonates, 24-36% of the blood samples could be saved.

Cited by 19 publications

References 25 publications

Bilistick: A Low-Cost Point-of-Care System to Measure Total Plasma Bilirubin

Bilistick: A Low-Cost Point-of-Care System to Measure Total Plasma Bilirubin

Transcutaneous Bilirubin Assessment for Screening of Hyperbilirubinemia in Term and Near-Term Neonates with Jaundice, a Comparative Study

Evaluating the Diagnostic Value of Skin Bilirubin in Comparison with Plasma Bilirubin to Identify Hyperbilirubinemia in Healthy Babies

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