Comparison of the tuberculin skin test and interferon-γ release assay for the diagnosis of latent tuberculosis infection before kidney transplantation

Kim, S. Y.; Jung, Gyeong Seo; Chang, Joon; Kim, M. S.; Kim, Y. S.; Kang, Young Ae; Joo, Dong Jin

doi:10.1007/s15010-012-0291-0

Cited by 48 publications

(31 citation statements)

References 32 publications

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“…Rejoining the hospital workforce was a reasonable associated factor for TST positivity because occupational exposure is a known risk factor for M. TB infection [1], [2]. Previous TB history was also considered a risk factor for an LTBI in other studies [15], [16]. Taken together, our data suggest that the TST may reflect the risk of LTBI among HCWs, and the observation that the HCWs who developed active TB after employment had a positive TST at employment supports this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Tuberculin Skin Test and Boosted Reactions among Newly Employed Healthcare Workers: An Observational Study

et al. 2013

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ObjectiveTo evaluate the prevalence of and factors associated with latent tuberculosis infection (LTBI) based on the tuberculin skin test (TST) and to estimate the boosted reaction rate among newly employed healthcare workers (HCWs).DesignNewly employed HCWs between January 2010 and July 2012 at Severance Hospital in South Korea were enrolled in this study. A one-step TST was conducted before October 2011, and a two-step TST after October 2011.ResultsOf 2132 participants, 778 (36.5%) had positive TST results. Being older (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.06–1.13, P<0.001), male (OR 1.78, 95% CI 1.21–2.62, P = 0.003), rejoining the hospital workforce (OR 1.58, 95% CI 1.04–2.40, P = 0.032), and having a previous history of tuberculosis (TB) (OR 18.21, 95% CI 2.15–154.10, P = 0.008) during the one-step period, and being older (OR 1.15, 95% CI 1.10–1.21, P<0.001) during the two-step period were significantly associated with a positive TST. A two-step TST was performed in 556 HCWs, and a boosted reaction was observed in 79 (14.2%). The induration size on the first TST (5–9-mm group) was the only factor associated with a boosted reaction on the second TST.ConclusionsThe prevalence of LTBI based on the TST among newly employed HCWs was high. The boosted reaction rate on two-step TST was not low; therefore, the use of two-step TST may be necessary for regular monitoring in countries with an intermediate TB burden and a high rate of Bacillus Calmette-Guérin vaccination.

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Section: Discussionmentioning

confidence: 99%

Tuberculin Skin Test and Boosted Reactions among Newly Employed Healthcare Workers: An Observational Study

et al. 2013

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“…Although in patients who are immunocompetent, using IGRA over TST may reduce the number of people considered for LTBI treatment because of its slightly higher specificity [14]; this may not be the case in transplant candidates. In a study on 126 kidney transplant candidates from South Korea, 19.3% had positive TST results and 42.1% had positive QFT-IT results [15]. The QFT-IT showed greater association than TST with risk factors for LTBI, including prior history of LTBI or active TB, abnormal chest imaging, and recent exposure to active TB.…”

Section: Key Pointsmentioning

confidence: 98%

Tuberculosis in solid organ transplant candidates and recipients

Subramanian¹

2014

Current Opinion in Infectious Diseases

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“…Male sex has been identified as an independent risk factor associated with LTBI in some studies [16]–[18], but several studies also report insignificant correlation between sex and LTBI [19], [20]. Most studies have focused on specific populations with relatively few case numbers.…”

Section: Introductionmentioning

confidence: 99%

Gender Disparities in Latent Tuberculosis Infection in High-Risk Individuals: A Cross-Sectional Study

et al. 2014

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Male predominance in active tuberculosis (TB) is widely-reported globally. Gender inequalities in socio-cultural status are frequently regarded as contributing factors for disparities in sex in active TB. The disparities of sex in the prevalence of latent TB infection (LTBI) are less frequently investigated and deserve clarification. In this cross-sectional study conducted in a TB endemic area, we enrolled patients at high-risk for LTBI and progression from LTBI to active TB from 2011 to 2012. Diagnosis of LTBI was made by QuantiFERON-TB Gold In-Tube (QFT-GIT). Differences in sex in terms of prevalence of LTBI and clinical predictors for LTBI were investigated. Associations among age, smoking status, and sex disparities in LTBI were also analyzed. A total of 1018 high-risk individuals with definite QFT-GIT results were included for analysis, including 534 males and 484 females. The proportion of LTBI was significantly higher in males than in females (32.6% vs. 25.2%, p = 0.010). Differences in the proportion of LTBI between sexes were most prominent in older patients (age ≥55 years). In multivariate analysis, independent clinical factors associated with LTBI were age (p = 0.014), smoking (p = 0.048), and fibro-calcified lesions on chest radiogram (p = 0.009). Male sex was not an independent factor for LTBI (p = 0.88). When stratifying patients according to the smoking status, the proportion of LTBI remained comparable between sexes among smokers and non-smokers. In conclusion, although the proportion of LTBI is higher in men, there is no significant disparity in terms of sex in LTBI among high-risk individuals after adjusting for age, smoking status, and other clinical factors.

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Comparison of the tuberculin skin test and interferon-γ release assay for the diagnosis of latent tuberculosis infection before kidney transplantation

Abstract: The positivity for QFT-GIT was higher than the positivity for TST, and QFT-GIT more accurately reflected the risk for LTBI. However, a further longitudinal study is needed in order to confirm that the QFT-GIT test can truly predict the development of TB after renal transplantation.

Cited by 48 publications

References 32 publications

Tuberculin Skin Test and Boosted Reactions among Newly Employed Healthcare Workers: An Observational Study

Tuberculin Skin Test and Boosted Reactions among Newly Employed Healthcare Workers: An Observational Study

Tuberculosis in solid organ transplant candidates and recipients

Gender Disparities in Latent Tuberculosis Infection in High-Risk Individuals: A Cross-Sectional Study

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