This study aimed to compare the outcomes of manual and automated chest compressions during virtual reality (VR)-based ambulance transport and measure the ventilation and airway pressure provided by different types of portable positive pressure ventilation in the national fire academy. The chest compression depths were 53.78 mm and 49.01 mm for automated and manual chest compressions, respectively, showing that automated chest compression achieved the appropriate compression depth. The compression rates were 101.8 times per min and 122.6 times per min for automated and manual compressions, respectively; however, the manual compression rate was irregular, ranging from 54∼178 times per min. The amounts of ventilation delivered by the portable positive pressure ventilator were 427.01 ml, 302.87 ml and 455.67 ml for models 1, 2 and 3, respectively, showing that models 1 and 3 delivered the appropriate amounts of ventilation. Therefore, automated chest compression is effective regarding compression depth and rate, incomplete release and release rate, hands-off time and compression site during VR-based patient transport. Portable positive pressure ventilators are easy to apply and can be used during patient transport; however, the ventilation varies according to the type used.