“…Over the years, attempts have been made to minimize the severity of post-ECT confusion by focussing on a variety of methodological factors within the clinician's control, such as electrode placement, stimulus waveform, stimulus dose, intervals between treatments and treatment number (Strain et al, 1968;Bidder et al, 1970;Weiner, 1984;Sackeim et al, 1986;Weiner et al, 1986;Sackeim et al, 1993). Though such strategies have produced some modest bene®t, further progress in this area most likely depends on a greater understanding of the underlying pathophysiological mechanisms.…”