Comparison of therapeutic efficacy and safety of radiofrequency ablation of hepatocellular carcinomas between internally cooled 15-G and 17-G single electrodes

Park, H J; Lee, M W; Song, Kyoung Doo; I, D; Rhim, Hyunchul; Kang, Tae Wook; Lim, Sanghyeok; Lim, Hyo Keun

doi:10.1259/bjr.20130534

Cited by 8 publications

(13 citation statements)

References 20 publications

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“…Recently, a clinical study comparing therapeutic efficacy and safety between 15-G and 17-G internally cooled electrodes of RFA for hepatocellular carcinoma was published. 19 According to that study, the 15-G internally cooled electrode created a larger ablation volume than did the 17-G electrode. However, the study was limited by selection bias owing to the retrospective study design.…”

Section: Discussionmentioning

confidence: 91%

“…In fact, in a recent clinical study, the complication rate was not significantly different between the two electrode groups. 19 Meanwhile, other complications such as collateral thermal injury to the surrounding tissue may be higher using the 15-G electrode owing to its larger ablation volume than when using the 17-G electrode. This concern regarding increased collateral thermal injury from a larger ablation zone also applies for microwave ablation, which is known to be able to create larger ablation zones with shorter ablation time.…”

Section: Full Paper: In Vivo and Ex Vivo Comparisons Of 15-g And 17-gmentioning

confidence: 99%

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Hepatic radiofrequency ablation:in vivoandex vivocomparisons of 15-gauge (G) and 17-G internally cooled electrodes

Song

Lee²,

Park³

et al. 2015

BJR

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Objective: To compare the performance of the 15-G internally cooled electrode with that of the conventional 17-G internally cooled electrode. Methods: A total of 40 (20 for each electrode) and 20 ablation zones (10 for each electrode) were made in extracted bovine livers and in in vivo porcine livers, respectively. Technical parameters, three dimensions [long-axis diameter (Dl), vertical-axis diameter (Dv) and short-axis diameter (Ds)], volume and the circularity (Ds/ Dl) of the ablation zone were compared. Results: The total delivered energy was higher in the 15-G group than in the 17-G group in both ex vivo and in vivo studies (8.78 6 1.06 vs 7.70 6 0.98 kcal, p 5 0.033; 11.20 6 1.13 vs 8.49 6 0.35 kcal, p 5 0.001, respectively). The three dimensions of the ablation zone had a tendency to be larger in the 15-G group than in the 17-G group in both studies. The ablation volume was larger in the 15-G group than in the 17-G group in both ex vivo and in vivo studies (29.61 6 7.10 vs 23.86 6 3.82 cm 3 , p 5 0.015; 10.26 6 2.28 vs 7.79 6 1.68 cm 3 , p 5 0.028, respectively). The circularity of ablation zone was not significantly different in both the studies. Conclusion: The size of ablation zone was larger in the 15-G internally cooled electrode than in the 17-G electrode in both ex vivo and in vivo studies. Advances in knowledge: Radiofrequency ablation of hepatic tumours using 15-G electrode is useful to create larger ablation zones.Radiofrequency ablation (RFA) is the most widely used local ablation technique for the management of primary and metastatic liver tumours. However, previous studies have reported that RFA showed a relatively higher local tumour progression rate than did hepatic resection.

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Section: Discussionmentioning

confidence: 91%

Section: Full Paper: In Vivo and Ex Vivo Comparisons Of 15-g And 17-gmentioning

confidence: 99%

Hepatic radiofrequency ablation:in vivoandex vivocomparisons of 15-gauge (G) and 17-G internally cooled electrodes

Song

Lee²,

Park³

et al. 2015

BJR

Self Cite

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“…This has been observed by other authors [16,[87][88][89][90][91][92], although the underlying mechanism has not been studied in depth till now.…”

Section: Electrode Diametermentioning

confidence: 73%

“…In hepatic RFA, the bleeding complication rate was similar for 1.8 mm (15 gauge) and 1.4 mm (17 gauge) electrodes [16,92].…”

Section: Electrode Diametermentioning

confidence: 80%

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Bipolar radiofrequency ablation with 2 × 2 electrodes as a building block for matrix radiofrequency ablation:Ex vivoliver experiments and finite element method modelling

Mulier

Jiang

Jamart

et al. 2015

International Journal of Hyperthermia

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Purpose: Size and geometry of the ablation zone obtained by currently available radiofrequency (RF) electrodes is highly variable. Reliability might be improved by matrix radiofrequency ablation (MRFA), in which the whole tumour volume is contained within a cage of x Â y parallel electrodes. The aim of this study was to optimise the smallest building block for matrix radiofrequency ablation: a recently developed bipolar 2 Â 2 electrode system. Materials and methods: In ex vivo bovine liver, the parameters of the experimental set-up were changed one by one. In a second step, a finite element method (FEM) modelling of the experiment was performed to better understand the experimental findings. Results:The optimal power to obtain complete ablation in the shortest time was 50-60 W. Performing an ablation until impedance rise was superior to ablation for a fixed duration. Increasing electrode diameter improved completeness of ablation due to lower temperature along the electrodes. A chessboard pattern of electrode polarity was inferior to a row pattern due to an electric field void in between the electrodes. Variability of ablation size was limited. The FEM correctly simulated and explained the findings in ex vivo liver. Conclusions: These experiments and FEM modelling allowed a better insight in the factors influencing the ablation zone in a bipolar 2 Â 2 electrode RF system. With optimal parameters, complete ablation was obtained quickly and with limited variability. This knowledge will be useful to build a larger system with x Â y electrodes for MRFA.

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Percutaneous ultrasonography-guided radiofrequency ablation of hepatocellular carcinomas: usefulness of image fusion with three-dimensional ultrasonography

Park¹,

Lee

Rhim

et al. 2015

Clinical Radiology

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Comparison of therapeutic efficacy and safety of radiofrequency ablation of hepatocellular carcinomas between internally cooled 15-G and 17-G single electrodes

Cited by 8 publications

References 20 publications

Hepatic radiofrequency ablation:in vivoandex vivocomparisons of 15-gauge (G) and 17-G internally cooled electrodes

Hepatic radiofrequency ablation:in vivoandex vivocomparisons of 15-gauge (G) and 17-G internally cooled electrodes

Bipolar radiofrequency ablation with 2 × 2 electrodes as a building block for matrix radiofrequency ablation:Ex vivoliver experiments and finite element method modelling

Percutaneous ultrasonography-guided radiofrequency ablation of hepatocellular carcinomas: usefulness of image fusion with three-dimensional ultrasonography

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