Comparison of Therapeutic Efficacy of Ferrous Ascorbate and Iron Polymaltose Complex in Iron Deficiency Anemia in Children: A Randomized Controlled Trial

Patil, Prashant; Geevarghese, P. J.; Khaire, Prabha; Joshi, Trupti; Suryawanshi, Amol Ratnakar; Mundada, Smita; Pawar, Shilpa; Farookh, Aziz

doi:10.1007/s12098-019-03068-2

Cited by 18 publications

(11 citation statements)

References 6 publications

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“…Of particular interest is ferrous ascorbate, which is the drug of choice for the treatment of iron deficiency anaemia, especially in developing countries like India. For example, doses of 3–6 mg/kg/day of ferrous ascorbate for 12 weeks in children have led to substantial increases in haemoglobin levels of about 4–5 g/dL, which was thus more efficient than other iron formulations including iron polymaltose and ferrous sulfate [ 189 , 190 , 191 , 192 ].…”

Section: The Role Of Ascorbic Acid In Iron Absorption and Iron Excmentioning

confidence: 99%

“…The ascorbic acid interactions with different oral, intramuscular and intravenous iron formulations are of pharmacological, toxicological and clinical importance [ 205 , 206 ]. There are many ferrous and ferric iron formulations available, such as oral ferrous sulfate, ferrous gluconate, ferric fumarate, ferric polymaltose, ferric maltol, ferric iron dextran, ferric iron sucrose, ferric gluconate, ferric saccharate, etc., used for treating many categories of iron-deficient patients [ 190 , 191 , 192 , 207 ]. While oral iron formulations may be beneficial for patients given the increase of iron absorption in the presence of ascorbic acid, there is no advantage to using vitamin C during intramuscular and intravenous administration of different iron formulations, given the increasing prospects of pro-oxidant and other toxicity [ 208 , 209 ].…”

Section: Drug Interactions With Ascorbic Acid and Ironmentioning

confidence: 99%

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Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications

et al. 2020

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Iron and ascorbic acid (vitamin C) are essential nutrients for the normal growth and development of humans, and their deficiency can result in serious diseases. Their interaction is of nutritional, physiological, pharmacological and toxicological interest, with major implications in health and disease. Millions of people are using pharmaceutical and nutraceutical preparations of these two nutrients, including ferrous ascorbate for the treatment of iron deficiency anaemia and ascorbate combination with deferoxamine for increasing iron excretion in iron overload. The main function and use of vitamin C is its antioxidant activity against reactive oxygen species, which are implicated in many diseases of free radical pathology, including biomolecular-, cellular- and tissue damage-related diseases, as well as cancer and ageing. Ascorbic acid and its metabolites, including the ascorbate anion and oxalate, have metal binding capacity and bind iron, copper and other metals. The biological roles of ascorbate as a vitamin are affected by metal complexation, in particular following binding with iron and copper. Ascorbate forms a complex with Fe3+ followed by reduction to Fe2+, which may potentiate free radical production. The biological and clinical activities of iron, ascorbate and the ascorbate–iron complex can also be affected by many nutrients and pharmaceutical preparations. Optimal therapeutic strategies of improved efficacy and lower toxicity could be designed for the use of ascorbate, iron and the iron–ascorbate complex in different clinical conditions based on their absorption, distribution, metabolism, excretion, toxicity (ADMET), pharmacokinetic, redox and other properties. Similar strategies could also be designed in relation to their interactions with food components and pharmaceuticals, as well as in relation to other aspects concerning personalized medicine.

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Section: The Role Of Ascorbic Acid In Iron Absorption and Iron Excmentioning

confidence: 99%

Section: Drug Interactions With Ascorbic Acid and Ironmentioning

confidence: 99%

Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications

et al. 2020

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“…Many expert groups and texts have recommended 3 mg/kg dose for managing IDA in children [7]. The difference in Hb rise with 6 mg doses in the present study with 3 mg in the study by Yewale and Dewan may partly be on account of lower baseline Hb in the present study by Patil et al as iron absorption is dependent on iron/ Hb status [5,6].…”

mentioning

confidence: 44%

“…As all iron needs to be changed to ferrous forms for absorption, ferrous salts are traditionally recommended [3,4]. In this issue of journal, Patil et al have compared ferrous ascorbate (FA) and iron polymaltose complex (IPC) for treating IDA in children [5]. With a 6 mg/kg daily dose, authors have demonstrated significant improvement in Hb at 12 wk compared to baseline in both the groups (Hb rise 4.88 + 1.28 g/dl with FA and 3.33 + 1.33 g/dl with IPC).…”

mentioning

confidence: 99%

Treating Iron Deficiency Anemia

Chandra

2019

Indian J Pediatr

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“…10,15 Patil et al study have compared ferrous ascorbate (FA) and iron polymaltose complex (IPC) for treating IDA in children and found that rise in hemoglobin was more with ferrous ascorbate than with IPC. 16 The significant rise of mean haemoglobin in ferrous ascorbate group could be due to better absorption of ferrous iron. Ferric forms are poorly soluble in acidic medium and need to be reduced to ferrous form before absorption by duodenal cytochrome B reductase to make it accessible to intestinal mucosal cell.…”

Section: Resultsmentioning

confidence: 96%

Comparison between oral ferrous ascorbate and colloidal iron in the treatment of iron deficiency anemia

Asati

Yadav

Mandot

2021

Int J Contemp Pediatr

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Background: Anemia is a global health issue. There is association of impaired cognition and iron deficiency anemia. Ferrous and ferric forms of oral iron preparations are available for the treatment of iron deficiency anemia. This study was conducted with an aim to compare the efficacy and safety of oral ferrous ascorbate and colloidal iron in the treatment of iron deficiency anemia.Methods: It was a prospective interventional study with 12 weeks of treatment protocols alternatively assigned to children diagnosed with iron deficiency anemia. Patients received either of two iron preparation used in study and they were assessed at week 0, 4, 8 and 12.Results: Hemoglobin (gm%) significantly increased from 7.40 to 12.87 in ferrous ascorbate group and from 7.24 to 11.32 in colloidal iron group at the end of 12 weeks of treatment (p<0.05). There was significant increase in corrected reticulocyte count (%) from 0.52 to 1.39 in ferrous ascorbate group and from 0.42 to 1.27 in colloidal iron group (p<0.05). Serum ferritin (mcg/liter) was also significantly increased from 11.54 to 21.53 in ferrous ascorbate group and from 10.57 to 20.52 in colloidal iron group at the end of 12 weeks (p<0.05).Conclusions: The present study concluded that the ferrous ascorbate is an efficient oral iron supplement in the treatment of iron deficiency anemia in the pediatric age group compared to colloidal iron.

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Comparison of Therapeutic Efficacy of Ferrous Ascorbate and Iron Polymaltose Complex in Iron Deficiency Anemia in Children: A Randomized Controlled Trial

Cited by 18 publications

References 6 publications

Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications

Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications

Treating Iron Deficiency Anemia

Comparison between oral ferrous ascorbate and colloidal iron in the treatment of iron deficiency anemia

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