Comparison of three commercially available softwares for measuring left ventricular perfusion and function by gated SPECT myocardial perfusion imaging

Ather, Sameer; Iqbal, Fahad; Gulotta, John; AlJaroudi, Wael; Heo, Jaekyeong; Iskandrian, Ami E.; Hage, Fadi G.

doi:10.1007/s12350-014-9885-5

Cited by 26 publications

(16 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of Wolak et al 17 and Ather et al 18 are not an absolute novelty. In 1997, preliminary data of a comparison of quantification of SPECT defect sizes by four different software programs, as well classification of defect abnormalities by four well-known laboratories and experts found a reasonable overall correlation of quantitative and visual defect sizes but demonstrated a substantial spread at Bland-Altman analysis of individual data points particularly for large defects.…”

Section: Quantitative Spect Myocardial Perfusion Imagingmentioning

confidence: 83%

“…Therefore, there were significant differences in myocardial perfusion quantification, diagnostic performance, and degree of automation of software packages. 17 Ather et al 18 more recently examined the correlation and agreement among these three programs in assessing perfusion defect size and reversible defect size (by polar maps) as well as LV ejection fraction, end-diastolic volume, end-systolic volume, and mass. Data were collected from 120 consecutive patients who had abnormal regadenoson SPECT myocardial perfusion imaging with a visually derived summed stress score C4 at Birmingham Medical Center (University of Alabama).…”

Section: Quantitative Spect Myocardial Perfusion Imagingmentioning

confidence: 99%

“…Both studies by Wolak et al 17 and Ather et al 18 only considered data without attenuation correction. Although some studies reported an increase in the diagnostic accuracy for the detection of coronary artery disease when myocardial perfusion SPECT is attenuation corrected, [21][22][23] only a few investigations addressed the accuracy of attenuation correction without any visual interpretation of corrected and non-corrected data.…”

Section: Impact Of Attenuation Correctionmentioning

confidence: 99%

See 2 more Smart Citations

Quantification of myocardial perfusion in clinical trials

Petretta

Nappi

Cuocolo

2015

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

In the current era of comparative effectiveness and outcomes research, 1 it is mandatory to have robust estimators of disease, also useful for risk stratification and healthy decision-making.2 Myocardial perfusion imaging with electrocardiographic gated single-photon emission computed tomography (SPECT) is widely used for diagnostic purpose and for risk stratification of patients with suspected or known coronary artery disease.3 However, improving nuclear cardiology practice is required to maximize its role in the presence of multiple concurrent imaging modalities. REGADENOSON SPECT MYOCARDIAL PERFUSION IMAGINGThe United States Food and Drug Administration approved the use of regadenoson, a selective adenosine A2A receptor agonist, on April 10, 2008 for SPECT myocardial perfusion imaging as vasodilator stress agent. 4 In patients undergoing SPECT myocardial perfusion imaging, regadenoson induces an increase in coronary blood flow similar to adenosine. Advantages of regadenoson over adenosine and dipyridamole include its rapid onset of maximal hyperemia (\1 minute), short duration of action, and fixed-dose bolus administration. 5In clinical settings, these advantages translate to a shorter stress protocol and more rapid patient throughput. In addition, regadenoson may be used safely in patients with asthma, chronic obstructive pulmonary disease, and end-stage kidney, and liver disease. Cerqueira et al 7 combined data from two identical double-blind, randomized, active comparator, double dummy, multicenter phase three trials, the ADVANCE MPI (ADenoscan Versus regAdenosoN Comparative Evaluation for Myocardial Perfusion Imaging) 1 and 2 designed to show the strength of agreement between sequential adenosine-regadenoson images. Using visual assessment of serial SPECT images for detection of ischemia relative to adenosine, non-inferiority of regadenoson was demonstrated for all patients and detection of ischemia was also comparable in specific subgroups. However, the average agreement rate between adenosineadenosine and adenosine-regadenoson were 0.62 ± 0.03 and 0.63 ± 0.02 (P = NS). Agreement was less for both agents in women vs men with moderate and large areas of ischemia. This is not surprising based on the significantly greater variability associated with visual as compared to quantitative analysis of SPECT images. 8 In a subsequent study, 9 the same group of investigators used quantitative SPECT analysis to determine the total left ventricular (LV) perfusion defect size and extent of ischemia in patients enrolled in the ADVANCE MPI 2 study randomized in a 2:1 ratio to either regadenoson (n = 495) or a second adenosine SPECT (n = 260) after a standard gated SPECT myocardial perfusion imaging. A single observer who was blinded to randomization and image sequence performed quantification. In this analysis, applying quantitative analysis, regadenoson induced virtually identical scintigraphic results as adenosine regarding the size and severity of LV perfusion defects and the extent of scintigraphic ischemia. In this...

show abstract

Section: Quantitative Spect Myocardial Perfusion Imagingmentioning

confidence: 83%

Section: Quantitative Spect Myocardial Perfusion Imagingmentioning

confidence: 99%

Section: Impact Of Attenuation Correctionmentioning

confidence: 99%

See 1 more Smart Citation

Quantification of myocardial perfusion in clinical trials

Petretta

Nappi

Cuocolo

2015

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

show abstract

“…In addition, the automatic quantification had a similar ability to assign perfusion abnormalities to the diseased coronary artery as compared to an expert panel [27]. Comparison of three commercially available software packages for measuring left ventricular perfusion and function by gated SPECT myocardial perfusion imaging showed significant differences in measuring perfusion abnormalities as well as LV function, and more importantly in defining small, moderate, or large ischemic burden [28]. Similar data for semi-quantitative analysis of 82 Rb PET are not available, but it is most likely that for 82 Rb PET these values are in the same range as for sestamibi SPECT.…”

mentioning

confidence: 94%

Left ventricular function in response to dipyridamole stress: head-to-head comparison between 82Rubidium PET and 99mTc-sestamibi SPECT ECG-gated myocardial perfusion imaging

Giorgi

Meneghetti

Soares

et al. 2016

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Rb summed rest (SRS), stress (SSS) and difference (SDS) scores, and LV end-diastolic (EDV) and end-systolic (ESV) volumes and left ventricular ejection fraction (LVEF) were compared. Results Bland-Altman analysis showed that with increasing ESVand EDV the difference between the two perfusion tracers increased both at rest and post-stress. The mean difference in EDV and ESV between the two perfusion tracers at rest could both be independently explained by the 82 Rb SDS and the sestamibi SRS. The combined models explained approximately 30% of the variation in these volumes between the two perfusion tracers (R 2 = 0.261, p = 0.005; R 2 = 0.296, p < 0.001, for EDVand ESV respectively). However, the mean difference in LVEF between sestamibi and

show abstract

“…3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Visual methods might be accurate but not reproducible, and automated methods might be reproducible but not precise. 20,21 A common practice is to compare patient data to a normal database, but alternative methods are available that compare the two sets of images to each other directly rather than comparing each to a normal database. Such an approach may improve the detection of smaller interval changes (improvement or worsening) since the intra-patient variation is expected to be smaller than the inter-patient variation.…”

mentioning

confidence: 99%