Comparison of time course of neuromuscular blockade in young children following rocuronium and atracurium

Abstract

126.3±61.0 s). Clinical duration with rocuronium was In order to compare the neuromuscular effects fol-22.8±5.31 min and thus significantly shorter than that lowing rocuronium 0.6 mg kg −1 and atracurium 0.5 mg of atracurium, which was 31.5±6.01 min. A statkg −1 30 children aged from 18 to 67 months were istically significant difference between rocuronium studied under the same anaesthetic conditions. After and atracurium also had been found for recovery of induction of anaesthesia with etomidate and fentanyl, T 1 to 50%, 75% and 90% as well as for the time neuromuscular blockade was monitored by recording taken to a TOF ratio of 70%. The recovery index for rocuronium and atracurium was not significantly difthe electromyographic response of the adductor polferent with 9.2±3.43 min and 10.9±2.65 min, relicis muscle to a supramaximal train-of-four (TOF) spectively. Thus, rocuronium may be more stimulation of the ulnar nerve at 2 Hz for 2 s at 20-s advantageous than atracurium for short-lasting surintervals. Intubation was performed when more than gical procedures in young children. 90% muscle relaxation was achieved, thereafter anaesthesia was maintained with 70% nitrous oxide in Keywords: anaesthesia, paediatric; monitoring, oxygen and isoflurane 0.5% end-tidal. Mean onset of neuromuscular blockade, neuromuscular relaxants, rocuronium, atracurium. action was significantly faster following rocuronium compared with other age groups [1,2,3], whereas atra-

Improving cost-efficiency at a hospital by showing the time-saving effect of using different neuromuscular blockers for short operations

“…Consistent with studies in paediatric patients, and in adult patients, this study showed that maximal NMB time to TOF0 was 87.38 ± 20.93 s in the rocuronium group and 119.30 ± 23.32 s in the atracurium group. Time to TOF75 was 38.88 ± 8.24 s in the rocuronium group and 51.37 ± 1.95 s in the atracurium group.…”

“…The effects of neuromuscular blockers (NMBs) can vary depending on the age of the patient. Many studies have reported that vecuronium and rocuronium shortened the duration of recovery in children and adolescents, while atracurium did not show such an effect . Ribeiro and colleagues compared the NMB effects of atracurium and rocuronium in children and reported that rocuronium was faster than atracurium in terms of the onset of blocking effect and duration of the recovery period …”

Quantitative identification of ventral/dorsal nerves through intraoperative neurophysiological monitoring by supervised machine learning

“…Therefore, it was reasonable to summarize that the trigger stimulation of spinal nerves started at least 40 min after the muscle relaxant. In the medical center where the author worked, rocuronium was used for intubation during the anesthesia in SDR, which was reported to take 35 min to recover 75% from rocuronium, offering strong support for the result acquired in this paper ( 24 , 25 ).…”

Spontaneous recovery from neuromuscular block after a single dose of a muscle relaxant in pediatric patients: A systematic review using a network meta‐analytic and meta‐regression approach

“…Electronic searches yielded 6345 potentially relevant trials, of which 71 (48 RCTs and 23 CCTs) eligible research papers (Figure 1 and Table S1) were identified, encompassing 4319 in the large majority ASA I‐II pediatric participants in 232 study arms 43–112 . We incorporated three RCTs that enrolled only a few ASA III patients 62,64,83 .…”