Comparison of Tissue Metal Concentrations in Zucker Lean, Zucker Obese, and Zucker Diabetic Fatty Rats and the Effects of Chromium Supplementation on Tissue Metal Concentrations

Staniek, Halina; Rhodes, Nicholas R.; Bona, Kristin R. Di; Deng, Guangcun; Love, Seth; Pledger, Leigh Ann; Blount, Jeremy; Gomberg, Emmalea; Grappe, Frances; Cernosek, Chelsea; Peoples, Brittany; Rasco, Jane F.; Krejpcio, Zbigniew; Vincent, John B.

doi:10.1007/s12011-012-9565-8

Cited by 26 publications

(21 citation statements)

References 26 publications

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“…After administration of CrPic or Mel or CrPic 1 Mel for 8-weeks, Cu levels were decreased when compared each group with HCDrats, respectively. Similar decrease had been observed in a study supplemented with Cr [51]. Nevertheless, no significant difference was observed after Mel administration for 6-weeks in the Cu level in Zucker diabetic rats [24].…”

Section: Discussionsupporting

confidence: 86%

Effect of chromium picolinate and melatonin either in single or in a combination in high carbohydrate diet‐fed male Wistar rats

2015

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This study is designed to know the effects of chromium picolinate (CrPic) and melatonin (Mel) each alone and in a combination on high carbohydrate diet‐fed (HCD‐fed) male Wistar rats that exhibit insulin resistance (IR), hyperglycemia, and oxidative stress. Wistar rats have been categorized into five groups. Each group consisted of six male Wistar rats, control rats (group I), HCD (group II), HCD + CrPic (group III), HCD + Mel (group IV), and HCD + CrPic + Mel (group V). Insignificant differences were observed in serum levels of superoxide dismutase, nitric oxide, and zinc in group III, group IV, and group V when each group was compared with group II rats respectively. Significant differences were observed in group III, group IV, and group V when each group was compared with group II in homeostasis model assessment‐estimated IR (P < 0.05, <0.0.05, <0.05), and in the levels of blood glucose (P < 0.05, <0.0.05, <0.05), total cholesterol (P < 0.05, <0.001, <0.001), triacylglycerols (<0.05, <0.001, <0.001), high density lipoprotein cholesterol (P < 0.05, <0.001, <0.001), malondialdehyde (P < 0.05, <0.05, <0.001), catalase (P <0.05, <0.05, <0.05), glutathione (P < 0.05, <0.05, <0.05), Mel (P < 0.05, <0.05, <0.001), and copper (P < 0.05, <0.05, < 0.001). In view of these results, HCD‐fed male Wistar rats that are destined to attain IR and T2DM through diet can be prevented by giving CrPic and Mel administration in alone or in a combination. © 2015 BioFactors, 42(1):106–114, 2016

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Section: Discussionsupporting

confidence: 86%

Effect of chromium picolinate and melatonin either in single or in a combination in high carbohydrate diet‐fed male Wistar rats

2015

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“…Changes in dietary Cr content could also affect mineral distribution, as shown in several earlier studies [7, 8, 41]. Cr is noted as affecting Fe metabolism mainly through the common transport protein transferrin [42], although no decreased accumulation of Fe was observed in rats supplemented with Cr.…”

Section: Discussionmentioning

confidence: 80%

“…Cr(III) exhibits low toxicity in animals, which may result from its poor transport across cellular membranes [3]. However, there are relatively few articles on the effect of Cr supplementation on the concentration of Cr and other minerals in animal tissues [4–8]. Studies of the distribution of Cr in the tissues of rats indicate that Cr content is greatest in the kidneys.…”

Section: Introductionmentioning

confidence: 99%

Effects of Exposure to Dietary Chromium on Tissue Mineral Contents in Rats Fed Diets with Fiber

Prescha

Krzysik

Zabłocka‐Słowińska

et al. 2014

Biol Trace Elem Res

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This study evaluated the effects of diets with fiber (cellulose and/or pectin) supplemented with chromium(III) on homeostasis of selected minerals in femurs, thigh muscles, livers, and kidneys of rats. For 6 weeks, male rats were fed experimental diets: a fiber-free diet (FF), a diet containing 5 % cellulose (CEL), 5 % pectin (PEC), or 2.5 % cellulose and 2.5 % pectin (CEL + PEC). These diets had 2.53 or 0.164 mg Cr/kg diet. The tissue levels of Ca, Mg, Zn, Fe, and Cr were determined by using atomic absorption spectrometry. Supplementing diets with Cr resulted in significantly higher Cr levels in the femurs of rats fed the CEL diet and significantly higher Cr and Fe levels in the rats fed the CEL + PEC diet compared to the rats fed FF diet. Muscle Ca content was significantly lower in the rats fed the CEL + PEC + Cr diet compared to the rats fed FF + Cr diet. The rats consuming the PEC + Cr diet had the highest liver Cr content. The highest kidney Zn content was observed in the rats fed diets containing Cr and one type of fiber. These results indicate that diets containing chromium at elevated dose and fiber have a significant effect on the mineral balance in rat tissues.

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“…Diabetes results in several metabolic changes, including alterations in the transport, distribution, excretion, and accumulation of metals [ 22 ]. To our knowledge, this is the first study to systematically analyze Cu and Zn in the heart, liver, kidney, muscle, spleen, and serum of type 1 diabetic mice.…”

Section: Discussionmentioning

confidence: 99%

Effect of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Metabolism of Copper and Zinc in Type 1 Diabetic Mice Model

Zhou

Wang

et al. 2015

Biol Trace Elem Res

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Alternations of copper (Cu) and zinc (Zn) status in diabetes have received a great attention. Tauroursodeoxycholic acid (TUDCA) and 4-phenylbutyric acid (PBA) could alleviate the increased endoplasmic reticulum (ER) stress and prevent insulin resistance. This study aimed to investigate the effect of TUDCA and PBA on metabolism of Cu and Zn in diabetic mice model. Diabetes was induced by streptozotocin in FVB mice treated with and without TUDCA and PBA. Determination of Cu and Zn in tissues and serum by acid digestion was followed by ICP-MS. The renal and serum Cu levels were significantly higher, while the hepatic Cu and Zn levels were significantly decreased in the diabetic mice at 2 weeks and 2 months after diabetes onset. The increase of cardiac Cu together with the decrease of muscular Zn was found in the diabetic mice only at 2 months. Cu levels were positively correlated with Zn in the heart, liver, kidney, muscle, spleen, and serum of diabetic and control mice at both 2 weeks and 2 months. Both PBA and TUDCA reduced serum Zn, and PBA reduced hepatic Cu to normal levels in the diabetic mice at two time points, while PBA normalized serum Cu in the diabetic mice only at 2 months. PBA increased hepatic Zn to normal levels in the diabetic mice at 2 weeks, while it partially increased hepatic Zn in the same group at 2 months. Therefore, maintaining homeostasis of Cu and Zn by TUDCA and PBA in diabetes needs to be received with special attention.

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Comparison of Tissue Metal Concentrations in Zucker Lean, Zucker Obese, and Zucker Diabetic Fatty Rats and the Effects of Chromium Supplementation on Tissue Metal Concentrations

Cited by 26 publications

References 26 publications

Effect of chromium picolinate and melatonin either in single or in a combination in high carbohydrate diet‐fed male Wistar rats

Effect of chromium picolinate and melatonin either in single or in a combination in high carbohydrate diet‐fed male Wistar rats

Effects of Exposure to Dietary Chromium on Tissue Mineral Contents in Rats Fed Diets with Fiber

Effect of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Metabolism of Copper and Zinc in Type 1 Diabetic Mice Model

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