Comparison of tobacco and alcohol consumption in young and older patients with oral squamous cell carcinoma: a systematic review and meta-analysis

Batistella, Elis Ângela; Gondak, Rogério; Rivero, Elena Riet Correa; Warnakulasuriya, Saman; Guerra, Eliete Neves Silva; Porporatti, André Luís; Canto, Graziela De Luca

doi:10.1007/s00784-022-04719-z

Cited by 10 publications

(5 citation statements)

References 58 publications

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“…In particular, the present retrospective study strongly focused at the level of (i) the EtG hair values and (ii) the oral occurrence of Streptococcus mitis , Candida albicans , Candida glabrata , and Neisseria subflava . In order to unveil the risk of alcohol consumption at the onset of UADT carcinoma, previous studies were mainly based on interviews that aimed to discover alcohol drinking habits without measuring the real, long-lasting alcohol consumption [ 69 , 70 , 71 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Alcohol Consumption and Oral Microbiota on Upper Aerodigestive Tract Carcinomas: A Pilot Study

et al. 2023

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Alcohol consumption is associated with oxidative stress and an increased risk of carcinoma of the upper aero-digestive tract (UADT). Recently, it has been found that some microorganisms in the human oral cavity may locally metabolize ethanol, forming acetaldehyde, a carcinogenic metabolite of alcohol. In a cohort of patients first visited for UADT cancers, we estimated their alcohol consumption by measuring Ethyl Glucuronide/EtG (a long-lasting metabolite of ethanol) in the hair and carbohydrate-deficient transferrin/CDT (short-term index of alcohol intake) in the serum. Moreover, we analyzed, by culture-based methods, the presence of Neisseria subflava, Streptococcus mitis, Candida albicans, and glabrata (microorganisms generating acetaldehyde) in the oral cavity. According to the EtG values, we correlated drinking alcohol with endogenous oxidative stress and the investigated microorganism’s presence. We found that 55% of heavy drinkers presented microorganisms generating acetaldehyde locally. Moreover, we found that the presence of oral acetaldehyde-producing bacteria correlates with increased oxidative stress compared to patients without such bacteria. As for the study of alcohol dehydrogenase gene polymorphisms (the enzyme that transforms alcohol to acetaldehyde), we found that only the “CGTCGTCCC” haplotype was more frequent in the general population than in carcinoma patients. This pilot study suggests the importance of estimating alcohol consumption (EtG), the presence of bacteria producing acetaldehyde, and oxidative stress as risk factors for the onset of oral carcinomas.

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Section: Discussionmentioning

confidence: 99%

The Impact of Alcohol Consumption and Oral Microbiota on Upper Aerodigestive Tract Carcinomas: A Pilot Study

et al. 2023

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“…In this regard, other studies have reported heterogenous data, with Kaminagakura et al (20) finding no differences in tobacco use between age groups while Farquhar et al found that younger patients were less likely to use tobacco (22). In a recent review by Batistella et al on over 15 000 pts, younger oral cancer patients tend to smoke and drink less than older counterparts (26). An interesting study regarding tobacco use and oral cancer in young adults was published by Subramaniam et al The authors examined the effect of tobacco use on survival stratified by age and concluded that tobacco use was an independent predictor for recurrence only in younger patients subgroup (27).…”

Section: Figurementioning

confidence: 99%

Oral cancer in young adults: should we approach these patients differently?

Szewczyk,

Pazdrowski,

Golusiński

et al. 2024

Front. Oncol.

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ObjectiveThe influence of age on treatment outcomes in oral cancer is unclear. We aimed to determine the prevalence of oral cancer in adults under age 45 and to compare treatment outcomes by age.MethodsRetrospective study of 284 patients treated for oral cancer from 2010 to 2021. The primary analysis involved the full cohort stratified by age (< vs. ≥ 45y). The second analysis included all patients under age 45 (n=44) matched 1:1 by sex and stage to older patients (age 55-70).ResultsIn the primary analysis, the only significant difference was more comorbidities in the older group (p<0.001). In the matched-pair analysis, older patients were more likely to be smokers (75% vs. 54%; p=0.045) and had more comorbidities (p=0.007). The mean PLR and NLR values were significantly higher in the younger group.ConclusionsNo significant differences were observed between age groups in disease stage or outcomes, suggesting that other variables are more important.

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“…The incidence of HNC has been steadily rising, and it is associated with substantial morbidity and mortality (3). Factors such as tobacco use, alcohol consumption, and human papillomavirus (HPV) infection contribute to its complex aetiology (4)(5)(6)(7). Despite advances in treatment, HNC prognosis remains challenging due to its aggressive nature and potential for recurrence (8,9).…”

Section: Introductionmentioning

confidence: 99%

Oral Microbiome Dynamics in Head and Neck Cancer Patients Undergoing Oral Healthcare: Implications for Prognosis and early diagnosis

Ji,

Qiao,

et al. 2024

Preprint

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Background: This study aims to investigate the influence of two oral mouthwash interventions on the oral microbiome of HNC patients at multiple time points, while simultaneously assessing their prognostic significance. Additionally, it seeks to identify distinctive oral microbiome biomarkers that are linked to different subtypes of HNC. Methods: Patients with HNC were subjected to random allocation into two distinct oral mouthwash intervention groups: the normal saline group denoted as N and the yikou gargle group employing chlorhexidine, represented as Y. Saliva samples were collected at three time points: baseline, post-operation, and before discharge from hospital. We employed 16S rRNA sequencing to comprehensively profile the composition of the oral microbiome, conducted an in-depth comparison of community diversity, and pinpointed enriched taxa within each oral mouth wash intervention group. Simultaneously, we conducted an investigation into the potential correlation between specific oral microbes and oral prognostic outcomes. Results: This study included 80 patients diagnosed with HNC scheduled for surgical intervention, and 30 patients underwent tracheostomy. Initially, both treatment groups had similar oral microbiome diversity. However, after surgery, the Y group exhibited a higher Shannon index and greater pronounced clustering variation compared to the N group. The genus Streptococcus dominated the oral microbiomes of both groups. The Y group showed a heightened abundance of taxa immediately after surgery when compared to the N group. In terms of implications for oral healthcare on oral prognosis, a notable finding was the significantly reduced severity of dental issues among patients in Y group when underwent tracheostomy as opposed to those in N group (p = 0.019). Conclusion: Our study provides insights into the impact of oral mouthwash interventions on the oral microbiome of HNC patients and their potential implications for prognosis. Understanding the role of the oral microbiome in HNC may pave the way for innovative therapeutic strategies that target the oral microbiota to improve treatment outcomes. Disparities in the oral microbiome among various types of HNC also suggest the potential for straightforward and non-invasive diagnostic approaches utilizing the oral microbiome.

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Comparison of tobacco and alcohol consumption in young and older patients with oral squamous cell carcinoma: a systematic review and meta-analysis

Cited by 10 publications

References 58 publications

The Impact of Alcohol Consumption and Oral Microbiota on Upper Aerodigestive Tract Carcinomas: A Pilot Study

The Impact of Alcohol Consumption and Oral Microbiota on Upper Aerodigestive Tract Carcinomas: A Pilot Study

Oral cancer in young adults: should we approach these patients differently?

Oral Microbiome Dynamics in Head and Neck Cancer Patients Undergoing Oral Healthcare: Implications for Prognosis and early diagnosis

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