Comparison of Toxic Metal Concentrations in Antidiabetic Herbal Preparations (ADHPs) Available in Bangladesh Using AAS and XRF Analytical Tools

Zamir, Rausan; Islam, Nazmul; Faruque, Akhter

doi:10.1155/2019/7154984

Cited by 7 publications

(10 citation statements)

References 11 publications

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“…Maghrabi reported similar results from different samples of herbal drugs marketed in Saudi Arabia, with the levels of Pb below the WHO permissible limit [26]. However, contrary to this finding, the concentration of lead above the WHO maximum permissible limit was reported in previous studies [12,[27][28][29][30]. Lead is one of the most toxic heavy metals and progressive exposure may cause poor muscle coordination, gastrointestinal symptoms, brain and kidney damage, hearing and vision impairments, and reproductive defects.…”

Section: Determination Of Heavy Metals In Herbal Preparationsmentioning

confidence: 53%

“…It regulates various biological processes like redox reactions, energy production, connective tissue formation, iron metabolism, and synthesis of neurotransmitters [9]. However, chronic exposure to a high concentration of copper causes irritation of nasal mucosa, vomiting, nausea, diarrhea, kidney, and liver damage [9,30].…”

Section: Determination Of Heavy Metals In Herbal Preparationsmentioning

confidence: 99%

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Health Risk Assessment and Determination of Some Heavy Metals in Commonly Consumed Traditional Herbal Preparations in Northeast Ethiopia

Meseret

Ketema

Kassahun

2020

Journal of Chemistry

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Background. Most traditional medicines were prepared from plant origins. These plants could be contaminated by heavy metals, pesticides, and/or toxins. Therefore, the aim of the present study was to determine the level of heavy metals such as lead (Pb), cadmium (Cd), chromium (Cr), and copper (Cu) in frequently used traditional herbal preparations sold in Northeast Ethiopia and to estimate their health risks associated with their daily intake. Methods. A total of 6 traditional herbal preparations were randomly collected from local herbal shops of Dessie and Kombolcha town, Northeast Ethiopia. The samples were prepared for analysis by wet digestion method using nitric acid and hydrochloric acid treatment. The accuracy of the method was analyzed by the spike recovery test. Determination of Pb, Cd, Cr, and Cu by microwave plasma atomic emission spectroscopy was made in herbal preparations traditionally used in Dessie and Kombolcha town, Northeast Ethiopia. By calculating estimated daily intake (EDI), hazard quotients (HQ), and Hazard Index (HI) of metals, the health risk associated with the consumption of the analyzed herbal preparations was also evaluated. Results. The levels of heavy metals were in the range of 3.0–3.92 mg/kg for Pb, 5.35–10.7 mg/kg for Cr, and 0.815–12.3 mg/kg for Cu. However, cadmium was not detected in any of the traditional herbal preparations. This study revealed that the level of Pb and Cu in all analyzed samples was within the WHO maximum permissible limit of 10 mg/kg and 40 mg/kg, respectively. The level of Cr in all traditional herbal preparations was beyond the WHO maximum permissible limit (2 mg/kg). From the health point of view, the HQ value of Cr for KD-03 and KD-04 is greater than 1, suggesting potential health risk. Furthermore, the HI value had revealed that the consumption of KD-02, KD-03, and KD-04 samples had the potential of posing health risks to consumers over long-term consumption of herbal preparations. Conclusion. This study showed that most of the metal concentration levels in the herbal products were within the WHO maximum permissible limits. However, all samples had Cr levels above the WHO maximum permissible limit. Based on the results of this study, there would be a noncarcinogenic health risk to the consumer associated with the consumption of some herbal preparations marketed in Northeast Ethiopia.

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Section: Determination Of Heavy Metals In Herbal Preparationsmentioning

confidence: 53%

Section: Determination Of Heavy Metals In Herbal Preparationsmentioning

confidence: 99%

Health Risk Assessment and Determination of Some Heavy Metals in Commonly Consumed Traditional Herbal Preparations in Northeast Ethiopia

Meseret

Ketema

Kassahun

2020

Journal of Chemistry

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“…Metal quanti cation was done by an atomic absorption spectrophotometer (AA-7000, Shimadzu, Japan) [12]. The spectrophotometer was operated in different modes: ame atomizer (FA), cold vapor (CV), and graphite tube atomizer (GTA), depending on the necessity.…”

Section: Sample Analysismentioning

confidence: 99%

“…Affordability and availability fuel the popularity of plant-based therapeutics, where the claimed safe and harmless advertisement of the medicines due to their natural origin plays a vital role [12]. However, the safety claim is made without proper scienti c evaluation.…”

Section: Introductionmentioning

confidence: 99%

“…The safety and quality of plant-based therapeutics have become major concerns for different stakeholders, which encompass general people, regulatory authorities, and pharmaceutical industries. However, studies conducted into toxic metals in the formulations manufactured and sold in Bangladesh are scarce, and reported studies were under our research endeavors [12], which were based on samples collected from Dhaka City and its surroundings.…”

Section: Introductionmentioning

confidence: 99%

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Health Risk Assessment of Toxic Metals Consumed Through Plant-Based Anti-Diabetic Therapeutics Collected in the Northern Divisional City of Rajshahi, Bangladesh

Islam,

Zamir,

Faruque

2024

Preprint

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The present study investigates human health risks upon consumption of herbal medicines in terms of ten toxic metals in twenty plant-based anti-diabetic therapeutics. The analysis of metals was determined by an atomic absorption spectrometer after microwave-assisted digestion. The computation of hazard quotients (HQ) and hazard indexes (HI) of metals leads to the assessment of non-carcinogenic health risks. Carcinogenic risk was assessed based on cancer slope factor (CSF) and chronic daily intake (CDI) values. Comparison with WHO regulatory cut-off points for each metal: seven samples for Mn, twelve samples for Hg, three samples for Cu, eight samples for Ni, four samples for Cd, two samples for Pb, one sample for Cr, and eight samples for Zn are unsafe to consume. Non-carcinogenic human health risk is predicted for Mn in seven samples, Fe in one sample, Hg in ten samples, Cu in three samples, Ni in one sample, and Pb in two samples. HI values greater than 1 predict non-carcinogenic health risk in thirteen samples. Incremental lifetime cancer risk (ILCR) remains for Pb in one sample, Cr in one sample, Cd in three samples, and Ni in nine samples. To guarantee consumer safety, the implementation of strict monitoring is suggested.

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Investigation of Heavy Metal Analysis on Medicinal Plants Used for the Treatment of Skin Cancer by Traditional Practitioners in Pretoria

Oladeji

Kopaopa

Mugivhisa

et al. 2023

Biol Trace Elem Res

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The use of medicinal plants for the treatment of diseases, including cancer, is acknowledged and accepted in many African nations. Heavy metal contamination of plant materials poses a potential health risk, particularly for populations that are already vulnerable. This study determines the levels of heavy metals in medicinal plant samples used for treatment of skin cancer and evaluate the health risk caused by heavy metals to the adult population in Pretoria, South Africa using inductively coupled plasma mass spectrometry (ICP-MS). The concentrations of metals were as follows; As (<0.2 – 1.04±0.026), Cd (0.02 ±0.00026 – 0.167±0.006), Pb (0.38 ±0.01 – 2.27±0.05), Cr (5.31±0.21– 26.9 ±3.96) mg/kg, and Hg which were lesser than 0.02 mg/kg. The mean concentrations of all analyzed heavy metals are above permissible limit except for Hg which are lower than the permissible limit. The Hazard Quotient (THQ) was less than 1 for all the heavy metals, suggesting that there are no obvious non-carcinogenic health risks associated with the consumption of these medicinal plants for now even though the prolonged use may result in health risks. The ingestion route was identified as the primary contributor to the overall risk by the health index (HI) values in the present study, which were more than 1, indicating that the combined effects of the heavy metal contaminants present in a particular herbal preparation pose health risk in the long term. Our findings support the need for close monitoring of potential heavy metal concentrations in medicinal plants given to patients from herbal shops.

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Comparison of Toxic Metal Concentrations in Antidiabetic Herbal Preparations (ADHPs) Available in Bangladesh Using AAS and XRF Analytical Tools

Cited by 7 publications

References 11 publications

Health Risk Assessment and Determination of Some Heavy Metals in Commonly Consumed Traditional Herbal Preparations in Northeast Ethiopia

Health Risk Assessment and Determination of Some Heavy Metals in Commonly Consumed Traditional Herbal Preparations in Northeast Ethiopia

Health Risk Assessment of Toxic Metals Consumed Through Plant-Based Anti-Diabetic Therapeutics Collected in the Northern Divisional City of Rajshahi, Bangladesh

Investigation of Heavy Metal Analysis on Medicinal Plants Used for the Treatment of Skin Cancer by Traditional Practitioners in Pretoria

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