2014
DOI: 10.21668/health.risk/2014.1.09.eng
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Comparison of toxicity of aqueous suspension of nano-and microfine silica in subchronic experiment

Abstract: Abstract. In subchronic experiment on Wistar's white male rats the negative effects have been studied and the comparative assessment of toxicity of an aqueous suspension of nano-and microfine silicon dioxide has been carried out. It was found that by intragastric administration for 90 days of the dose of 14.6 mg/kg, corresponding to the predicted threshold dose (LOAEL), the aqueous suspension of nanosized silicon dioxide causes immune irritating, cytolytic and inflammatory effects, verified by the deviation of… Show more

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