2014
DOI: 10.1016/j.nucmedbio.2014.04.004
|View full text |Cite
|
Sign up to set email alerts
|

Comparison of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid (anti-[18F]FACBC) accumulation in lymph node prostate cancer metastasis and lymphadenitis in rats

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
11
0

Year Published

2017
2017
2023
2023

Publication Types

Select...
4
3

Relationship

1
6

Authors

Journals

citations
Cited by 16 publications
(11 citation statements)
references
References 18 publications
0
11
0
Order By: Relevance
“…The tracer trans-1-amino-3-[ 18 F]fluorocyclobutanecarboxylic acid ([ 18 F]FACBC) is a synthetic amino acid that is taken up by activated immune cells [76, 77]. [ 18 F]FACBC uptake ratios of stimulated versus non-stimulated T-cells in a rat model rapidly increased in comparison to B-cells and macrophages.…”
Section: Cells Surface Markers For In Vivo Imaging Of T-cell Activationmentioning
confidence: 99%
“…The tracer trans-1-amino-3-[ 18 F]fluorocyclobutanecarboxylic acid ([ 18 F]FACBC) is a synthetic amino acid that is taken up by activated immune cells [76, 77]. [ 18 F]FACBC uptake ratios of stimulated versus non-stimulated T-cells in a rat model rapidly increased in comparison to B-cells and macrophages.…”
Section: Cells Surface Markers For In Vivo Imaging Of T-cell Activationmentioning
confidence: 99%
“…Fluciclovine might potentially overcome some of the known limitations of [ 18 F]FDG because the degree of fluciclovine metabolic upregulation by inflammation and infection is minimal especially when compared to FDG . In our case, fluciclovine uptake was seen to reflect the true pathologic disease burden in our patient.…”
Section: Discussionmentioning
confidence: 63%
“…Several types of inflammatory cells such as lymphocytes, neutrophils, macrophages, dendritic cells, and mast cells exist in the tumor microenvironment 39; however, T-lymphocytes and/or monocytes/macrophages were the main inflammatory cells infiltrating or surrounding tumor lesions in our bone metastatic models. The relatively high accumulation of 3 H-FDG in the tumors with inflammation is reasonable because many non-clinical and clinical reports exist on the extensive accumulation of 18 F-FDG in inflammation, which is one cause of false-positives in FDG-PET imaging 15,40,41. Thus, a broader distribution of T/BG ratios of 3 H-FDG compared to 14 C-fluciclovine may indicate inflammation (Fig.…”
Section: Discussionmentioning
confidence: 97%
“…3D). However, 18 F-fluciclovine is also taken up by activated lymphocytes, although the amount is smaller than that of 18 F-FDG 15,41. This finding may be because of the upregulation of LAT1 and ASCT2, which are the main AATs for fluciclovine uptake in cancer cells 14,16, along with the activation of T-lymphocytes 42,43.…”
Section: Discussionmentioning
confidence: 97%
See 1 more Smart Citation