Comparison of transcranial magnetic stimulation measures obtained at rest and under active conditions and their reliability

Ngomo, Suzy; Léonard, Guillaume; Moffet, Hélène; Mercier, Catherine

doi:10.1016/j.jneumeth.2011.12.012

Cited by 143 publications

(175 citation statements)

References 50 publications

(80 reference statements)

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“…Similar to other studies (Cacchio, Paoloni, 2011, Carroll, Riek, 2001, Ngomo, Leonard, 2012, Wheaton, Villagra, 2009, we found that active motor threshold demonstrated good reliability and was superior to the MEP size measures overall. This indicates that differences in threshold between sessions did not contribute substantially to the poor intersession reliability of MEP size in the stroke group.…”

Section: Reliability In Stroke and Control Groupssupporting

confidence: 88%

“…Previous studies examining the reliability of MEPs have mainly focused on hand and forearm muscles (Bastani and Jaberzadeh, 2012, Carroll et al, 2001, Christie et al, 2007, Kamen, 2004, Livingston and Ingersoll, 2008, McDonnell et al, 2004, Mortifee et al, 1994, Ngomo et al, 2012, with a smaller number of studies examining muscles from the lower limb (Cacchio et al, 2009, Cacchio et al, 2011, Tallent et al, 2012, van Hedel et al, 2007, Wheaton et al, 2009). Most authors have reported good or excellent reliability of MEP amplitude measurements within and between sessions but this is not always consistent (Livingston andIngersoll, 2008, McDonnell, Ridding, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Of note, the two studies examining responses in patients with stroke found poor-average reliability of MEP amplitude in the lower limb muscles on the paretic side. This factor may be compounded by the fact that muscle activation is often required to elicit MEPs in paretic muscles, as MEP reliability is reduced during muscle activity compared to resting conditions (Kamen, 2004, Ngomo, Leonard, 2012, Tallent, Goodall, 2012, van Hedel, Murer, 2007.…”

Section: Introductionmentioning

confidence: 99%

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Reliability of lower limb motor evoked potentials in stroke and healthy populations: How many responses are needed?

Lewis

Signal

Taylor

2014

Clinical Neurophysiology

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Highlights Intrasession reliability of lower limb motor evoked potentials (MEPs) is excellent in patients with stroke when using as few as 6 responses  Intersession reliability of MEPs is poor in patients with stroke, questioning the ability of this measure to reliably capture changes in corticomotor excitability over time  Measuring the amplitude of each single MEP or using MEP area provides a more reliable measure of MEP size than averaging non-rectified responses AbstractObjective: To determine the intra-and inter-session reliability of motor evoked potential (MEP) size parameters in the lower limb of patients with stroke, focussing on the number of MEPs collected and the method of measuring MEP size. Methods: Transcranial magnetic stimulation was used to elicit MEPs in the soleus muscle of patients with stroke (n=13) and age-matched healthy participants (n=13) during low level muscle activation. Two sets of 10 responses were collected in the first session and a further 10 responses collected in a second session held 7 days later. Four MEP size measurements were made using 4, 6, 8, or all 10 of the MEPs collected. Intra-and inter-session reliability was examined using intraclass correlation coefficients (ICC) and typical percentage error. Results: Intrasession ICC statistics using 6 or more MEPs were >0.85 in the stroke group but intersession values were all <0.5.Reliability was best when measuring parameters from individual MEPs rather than averaged responses. Conclusions: Reliability of intrasession MEP size is excellent in the lower limb of patients with stroke using as few as 6 MEPs but intersession reliability is poor. Significance:Comparing MEP size measures across two or more sessions is questionable in the lower limb of patients with stroke.3

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Section: Reliability In Stroke and Control Groupssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reliability of lower limb motor evoked potentials in stroke and healthy populations: How many responses are needed?

Lewis

Signal

Taylor

2014

Clinical Neurophysiology

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“…However, our inter-rater agreement for resting ppTMS measures was no better for ICF than SICI. Ngomo et al 9 observed that first dorsal interosseous SICI was reliable under resting but not active conditions. We observed both resting and active SICI measures were agreeable between sessions, though our agreement was greater for resting SICI.…”

Section: Discussionmentioning

confidence: 99%

Agreement Between Investigators Using Paired-Pulse Transcranial Magnetic Stimulation to Assess Quadriceps Intracortical Excitability

Thomas

Pietrosimone

Bayer

2016

Journal of Sport Rehabilitation

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Context: Transcranial magnetic stimulation (TMS) may provide important information regarding the corticospinal mechanisms that may contribute to the neuromuscular activation impairments. Paired-pulse TMS testing is a reliable method for measuring intracortical facilitation and inhibition; however, little evidence exists regarding agreement of these measures in the quadriceps. Objective: To determine the between-sessions and interrater agreement of intracortical excitability (short- and long-interval intracortical inhibition [SICI, LICI] and intracortical facilitation [ICF]) in the dominant-limb quadriceps. Design: Reliability study. Setting: Research laboratory. Participants: 13 healthy volunteers (n = 6 women; age 24.7 ± 2.1 y; height 1.7 ± 0.1 m; mass 77.1 ± 17.4 kg). Intervention: Participants completed 2 TMS sessions separated by 1 wk. Main Outcome Measures: Two investigators measured quadriceps SICI, LICI, and ICF at rest and actively (5% of maximal voluntary isometric contraction). All participants were seated in a dynamometer with the knee flexed to 90°. Intracortical-excitability paradigm and investigator order were randomized. Bland-Altman analyses were used to establish agreement. Results: Agreement was stronger between sessions within a single investigator than between investigators and for active than resting measures. Agreement was strongest for resting SICI and active ICF and LICI between sessions for each investigator. Conclusions: Quadriceps intracortical excitability may be measured longitudinally by a single investigator, though active muscle contraction should be elicited during testing.

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“…How do these thresholds vary among individuals and situations? Some members of the MSD axis conduct research on neuromuscular mechanisms that may control the response to excessive exposure, focusing particularly on the biomechanical aspects of motor control (Côté et al, 2008;Fuller, Fung and Côté, 2011) and functional organization of the central nervous system (CNS) (Ngomo, Leonard and Mercier, 2012;Ngomo et al, 2011). For example, acute pain appears to stimulate complex adaptations such as increased movement variability, whereas chronic pain appears to limit variability (Côté and Hoeger Bement, 2010).…”

Section: Wmsd Exposure Measurement and Underlying Physiological Mechamentioning

confidence: 99%

Quebec Research on Work-related Musculoskeletal Disorders

Côté

Ngomo

Stock

et al. 2014

Self Cite

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This paper aimed to demonstrate the contribution of the research performed by the musculoskeletal disorders (MSD) Research Axis group of the Quebec Occupational Health and Safety Research Network towards better understanding of work-related MSD (WMSD) development and prevention. Although the group targets its work to the Quebec population, its work has significant impact around the world, placing MSD axis members and knowledge and expertise created in Quebec on the international map. Results from the contribution of members are relevant, primarily in the demonstration of the implication of physical workload as well as organizational and psychosocial work-related factors in the development of WMSDs. Also, members have demonstrated that gender, sex, social class, age and ethno-cultural groups interact in various ways with WMSD determinants. Efforts are devoted towards improving understanding of the physiological responses linked with MSDs, which could also lead to new workplace practices in rehabilitation. The group emphasizes the integration of prevention procedures from the design stage to the workplace intervention. Members have proposed research-based tools for best practices at work and also an original conceptual model as a key, novel element of a theoretical conceptualization of WMSDs. Moreover, the group focuses on improving WMSD surveillance, using multiple sources of information, providing information on newly identified health risks and developing new methods of assessing risk in order to effectively prevent disability in the working population. Finally, results from research of the MSD axis group have implications for orienting legal processes, improving legal recognition of MSDs as occupational diseases, and contributing to the evolution of legal thinking. However, much remains to be done. To that end, the group plans and encourages new initiatives for further advancement. In conclusion, the originality of the work places the group in a favourable position to address the complexity underlying WMSDs, combining expertise that enriches fundamental, clinical and population-based research.

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Comparison of transcranial magnetic stimulation measures obtained at rest and under active conditions and their reliability

Abstract: 2

Cited by 143 publications

References 50 publications

Reliability of lower limb motor evoked potentials in stroke and healthy populations: How many responses are needed?

Reliability of lower limb motor evoked potentials in stroke and healthy populations: How many responses are needed?

Agreement Between Investigators Using Paired-Pulse Transcranial Magnetic Stimulation to Assess Quadriceps Intracortical Excitability

Quebec Research on Work-related Musculoskeletal Disorders

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