Comparison of Treatment Volumes and Techniques in Prostate Cancer Radiation Therapy

Lee, Catherine T.; Dong, Lei; Ahamad, A.; Choi, Haesun; Cheung, R.; Lee, Andrew K.; Horne, David; Breaux, Allan J.; Kuban, Deborah A.

doi:10.1097/01.coc.0000172281.32437.d4

Cited by 26 publications

(12 citation statements)

References 18 publications

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“…Likewise, respective V60 doses with IMRT and 3D-CRT were 20 Gy and 40 Gy for rectum, and 35 Gy and 42 Gy for bladder. Our results are consistent with the study by Zelefsky et al (11 ) and 2 other similar studies by Lee et al (12) and Zhu et al (13) regarding dose homogeneity and critical organ doses.…”

Section: Discussionsupporting

confidence: 94%

Dosimetric Evaluation of Intensity Modulated Radiotherapy and 4-Field 3-D Conformal Radiotherapy in Prostate Cancer Treatment

Uysal¹,

Beyzadeoğlu²,

Sager³

et al. 2013

Balkan Med J

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Objective: Dexmedetomidine has been reported to produce analgesia after intrathecal administration. In the present study the α2-adrenoceptor agonist dexmedetomidine was evaluated for its potential spinal neurotoxic effects.Material and Methods: Three days after intrathecal cannulation, rats were administered either dexmedetomidine (3 μg/30 μL, i.t.) or saline (30 μL, i.t.). Antinociceptive, sedative and motor effects of intrathecal administrations of dexmedetomidine or saline were evaluated during 90 min. The tail-flick and hot plate tests were used to assess the thermal nociceptive threshold. Seven days after drug administration, animals were sacrified and spinal cords were evaluated for histopathological changes by light microscopy.Results: Dexmedetomidine administered intrathecally produced antinociception. Antinociception was accompanied by immediate sedation and loss of placing-stepping reflexes that lasted over 40 min in all dexmedetomidine administered rats. In all rats, microscopic examination revealed mild gliosis and minimal infiltration of inflamatory r cells in posterior white matter. Mild (total score 4-6) histopathologic lesions were seen in four animals in dexmedetomidine adminisered rats, but there was no statistically significant difference when compared with the saline administered rats. Conclusion:We observed that intrathecal injections of dexmedetomidine at the dose of 3 μg/30 μL produce antinociception but did not cause any histopathological sign of injury in the spinal cord.

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Section: Discussionsupporting

confidence: 94%

Dosimetric Evaluation of Intensity Modulated Radiotherapy and 4-Field 3-D Conformal Radiotherapy in Prostate Cancer Treatment

Uysal¹,

Beyzadeoğlu²,

Sager³

et al. 2013

Balkan Med J

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“…In comparison to 3DCRT, dose conformality can be improved using the IMRT technique [6,14,23]. The volume of organs at risk can be especially reduced within the high dose region.…”

Section: Introductionmentioning

confidence: 99%

Combination of Dose Escalation with Technological Advances (Intensity-Modulated and Image-Guided Radiotherapy) Is Not Associated with Increased Morbidity for Patients with Prostate Cancer

et al. 2011

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Purpose:The aim was to evaluate treatment-related morbidity after intensity-modulated (IMRT) and image-guided (IGRT) radiotherapy with a total dose of 76 Gy in comparison to conventional conformal radiotherapy (3DCRT) up to 70.2-72 Gy for patients with prostate cancer. Patients and Methods: All patients were prospectively surveyed prior to, on the last day, as well as after a median time of 2 and 16 months after RT using a validated questionnaire (Expanded Prostate Cancer Index Composite). Criteria for the 78 matched pairs after IMRT vs. 3DCRT were patient age, use of antiandrogens, treatment volume (± whole pelvis), prognostic risk group, and urinary/bowel/sexual quality of life (QoL) before treatment. Results: QoL changes after dose-escalated IMRT were found to be similar to QoL changes after 3DCRT in all domains. Only sexual function scores more than 1 year after RT decreased slightly more after 3DCRT in comparison to IMRT (mean 9 vs. 6 points; p = 0.04), with erections firm enough for intercourse in 14% vs. 30% (p = 0.03). Painful bowel movements were reported more frequently after 3DCRT vs. IMRT 2 months after treatment (≥ once a day in 10% vs. 1%; p = 0.03), but a tendency for higher rectal bleeding rates was found after IMRT vs. 3DCRT more than 1 year after RT (≥ rarely in 20% vs. 9%; p = 0.06). Conclusion: Combination of dose escalation with technological advances (IMRT and IGRT) is not associated with increased morbidity for patients with prostate cancer. Verknüpfung einer Dosiseskalation mit technologischen Fortschritten (intensitätsmodulierte und bildgeführte Radiotherapie) ist bei Patienten mit Prostatakarzinom nicht mit erhöhter Morbidität assoziiertZiel: Ziel war die Analyse therapiebedingter Morbidität nach intensitätsmodulierter (IMRT) und bildgeführter (IGRT) Radiotherapie mit einer Gesamtdosis von 76 Gy im Vergleich zur konventionellen konformalen Radiotherapie (3DCRT) bis 70,2-72 Gy bei Patienten mit einem Prostatakarzinom. Patienten und Methoden: Alle Patienten wurden prospektiv vor Beginn, am letzten Tag, median 2 Monate und 16 Monate nach RT mittels eines validierten Fragebogens befragt (Expanded Prostate Cancer Index Composite). Kriterien für 78 gematchte Paare nach IMRT vs. 3DCRT waren das Patientenalter, der Einsatz eines Antiandrogens, Zielvolumen (± Becken), prognostische Risikogruppe und Lebensqualität (LQ) beim Wasserlassen/Stuhlgang/Sexualität vor der Behandlung. Ergebnisse: LQ-Veränderungen nach dosiseskalierter IMRT waren den LQ-Veränderungen nach 3DCRT in allen Domänen sehr ähnlich. Nur der Punktwert für die sexuelle Funktion fiel über ein Jahr nach der Behandlung nach 3DCRT etwas mehr als nach IMRT (durchschnittlich 9 vs. 6 Punkte; p = 0,04), mit ausreichender Erektion für Geschlechtsverkehr in 14% vs. 30% (p = 0,03). Schmerzhafter Stuhlgang wurde zwei Monate nach Therapie häufiger nach 3DCRT als nach IMRT berichtet (≥1-mal täglich in 10% vs. 1%; p = 0,03); jedoch fand sich über ein Jahr nach RT die Tendenz zu einer häufigeren Rate rektaler Blutungen nach IMRT als nach 3DCRT (≥ s...

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“…The aim of modern imaging and treatment techniques is to improve biochemical control rates without increasing toxicity. Image-guided radiotherapy (IGRT) allows a reduction of safety margins [3,18,24,27,28], intensity-modulated radiotherapy (IMRT) a better dose conformality in comparison to three-dimensional conformal radiotherapy techniques [9,22]. Cellini et al found the origin of all local recurrences within the initial tumor volume, supporting the rationale of a selective dose escalation only to the intraprostatic lesion [6].…”

Section: Introductionmentioning

confidence: 99%

Intensity-Modulated Radiotherapy for Prostate Cancer Implementing Molecular Imaging with 18F-Choline PET-CT to Define a Simultaneous Integrated Boost

et al. 2010

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Comparison of Treatment Volumes and Techniques in Prostate Cancer Radiation Therapy

Cited by 26 publications

References 18 publications

Dosimetric Evaluation of Intensity Modulated Radiotherapy and 4-Field 3-D Conformal Radiotherapy in Prostate Cancer Treatment

Dosimetric Evaluation of Intensity Modulated Radiotherapy and 4-Field 3-D Conformal Radiotherapy in Prostate Cancer Treatment

Combination of Dose Escalation with Technological Advances (Intensity-Modulated and Image-Guided Radiotherapy) Is Not Associated with Increased Morbidity for Patients with Prostate Cancer

Intensity-Modulated Radiotherapy for Prostate Cancer Implementing Molecular Imaging with 18F-Choline PET-CT to Define a Simultaneous Integrated Boost

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