2022
DOI: 10.1002/sim.9554
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Comparison of treatments with ordinal responses in trials with sequential monitoring and response‐adaptive randomization

Abstract: In clinical trials, comparisons of treatments with ordinal responses are frequently conducted using the proportional odds model. However, the use of this model necessitates the adoption of the proportional odds assumption, which may not be appropriate. In particular, when responses are skewed, the use of the proportional odds model may result in a markedly inflated type I error rate. The latent Weibull distribution has recently been proposed to remedy this problem, and it has been demonstrated to be superior t… Show more

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