Comparison of two alcohol-based surgical scrub solutions with an iodine-based scrub brush for presurgical antiseptic effectiveness in a community hospital

Gupta, Chakshu; Czubatyj, A.M.; Briski, Laurence E.; Malani, Ashok K.

doi:10.1016/j.jhin.2006.06.026

Cited by 49 publications

(28 citation statements)

References 9 publications

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“…60,[333][334][335] Regarding surgical hand preparation, an alcohol-based waterless surgical scrub was shown to have the same efficacy and demonstrated greater acceptability and fewest adverse effects on skin compared with an alcohol-based water-aided solution and a brush-based iodine solution. 336 Alcohols are flammable, and HCWs handling alcohol-based preparations should respect safety standards (see Part I, Section 23.6). Because alcohols are volatile, containers should be designed so that evaporation is minimized and initial concentration is preserved.…”

Section: Alcoholsmentioning

confidence: 99%

“…Remove debris from underneath fingernails using a nail cleaner, preferably under running water (II E. Surgical hand antisepsis should be performed using either a suitable antimicrobial soap or suitable alcohol-based handrub, preferably with a product ensuring sustained activity, before donning sterile gloves (IB). 162,227,282,336,463,482,524,525 F. If quality of water is not assured (as described in Table I.11.3) in the operating theatre, surgical hand antisepsis using an alcohol-based handrub is recommended before donning sterile gloves when performing surgical procedures (II). 250,282,463,482 G. When performing surgical hand antisepsis using an antimicrobial soap, scrub hands and forearms for the length of time recommended by the manufacturer, typically 2-5 minutes.…”

Section: Recommendations For Surgical Hand Preparationmentioning

confidence: 99%

See 1 more Smart Citation

Hand Hygiene

Longtin¹,

Sax²,

Allegranzi³

et al. 2011

N Engl J Med

108

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Section: Alcoholsmentioning

confidence: 99%

Section: Recommendations For Surgical Hand Preparationmentioning

confidence: 99%

Hand Hygiene

Longtin¹,

Sax²,

Allegranzi³

et al. 2011

N Engl J Med

108

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“…Above pH 8.0 CHD base is precipitated and in more acid conditions there is gradual deterioration of activity because the compound is less stable. [7,8]. Chlorhexidine is a chemical antiseptic.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a simple, fast, isocratic stability indicating RP-HPLC-UV method for the determination of chlorhexidine and its impurity para-chloroaniline in bulk and finished product

Mohammed¹,

Aziz²

2017

IOSRPHR

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Abstract:-A simple, isocraticRP HPLC-UV method was developed for the simultaneous determination of chlorhexidine (CHD) and p-Chloroaniline (pCA) inchlorhexidine mouth rinses. An excellent separation obtainedbyC18 column (200mm × 4.6 mm, 3μm). Mobile phasewas acetate buffer:methanol in a 45:55 ratio,flowrate was 1.0 ml/min. Both ingredient and an impuritywere detected at 254 nm,injection volume was 20µl and the analysis temperature was room temperature.Resolution4.7,retention times was3.1min and 5.7 min for pCAand CHD respectively. The proposed method was testedforsystem suitability, linearity, range, precision, accuracy, specificity, robustness, detection and quantification limits. The linearity range was40-160µg/ml forCHD and0.3-1.2 µg/ml forpCA.The correlation coefficient of the regression line was 1.000 for both components. Method robustness was tested under nine different conditions using sampleswith a known content. For CHD, the mean of the nine assays was 99.95% andthe RSD was 0.16%. ForpCA, the mean of the nine assays was 99.98% and the RSD was 0.24%. The results show that this is a simple method that can be applied to the analysis of Chlorhexidineproductswith satisfactory degrees of accuracy and precision. Due to the selected optimized conditions, this method can be used with the minimum requirements of an isocratic HPLC system.

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“…11 Alcohol rubs have been shown to be effective in other studies, as well. An alcohol-based waterless rub and an alcohol-based water-aided scrub solution were compared to a traditional PI aqueous scrub in a study by Gupta et al 12 The investigators found no difference in CFU reductions among the 3 solutions; however, the alcohol-based waterless rub was less irritating and was the preferred product among the participants. Herruzo et al studied the relative efficacy of an alcohol rub versus the standard surgical scrubs of CHG and PI.…”

mentioning

confidence: 99%

“…In addition, alcohol rubs tend to have shorter application times than aqueous scrubs and can improve compliance with surgical hand antisepsis among members of the surgical team. 11,12,14,15 Several studies have also demonstrated a lower cost for alcohol rubs as compared to traditional scrubs with brushes. 14, 15 We found no evidence regarding either the need for a traditional scrub as the first of the day or the effect of equipment such as nail-cleaning devices.…”

mentioning

confidence: 99%