Comparison of two anesthetic protocols for feline blood donation

Killos, Maria; Graham, Lori; Lee, Justine

doi:10.1111/j.1467-2995.2010.00527.x

Cited by 22 publications

(35 citation statements)

References 27 publications

(39 reference statements)

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“…Several veterinary studies have described the effects of sedation on feline blood donors. Killos et al found that 84% of blood donor cats anesthetized with sevofluorane and 42% of donor cats anesthetized with a combination of ketamine, midazolam, and butorphanol developed hypotension that required treatment with intravenous fluid therapy . In this report, cats that received injectable sedation also developed hyperthermia and showed a slower return to normal behavior than those anesthetized with sevoflurane .…”

Section: Discussionmentioning

confidence: 56%

“…Therefore, on‐demand feline donation is often the preferred option for veterinarians. Sedation with recommended agents, including combinations of ketamine and midazolam or anesthesia with inhalant anesthetics to facilitate blood collection, may lead to hypotension and death . Performing feline donations without sedation, as is standard practice for canine donation, may have a number of advantages including decreased donor morbidity and mortality, thereby making the process more appealing to the owners of potential blood donors.…”

Section: Introductionmentioning

confidence: 99%

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Retrospective evaluation of unexpected events during collection of blood donations performed with and without sedation in cats (2010–2013)

Doolin

Chan

Adamantos

et al. 2017

J Vet Emergen Crit Care

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Objectives -Describe unexpected events (UEs) that occurred during blood donation in cats with and without sedation.Design -Retrospective observational study (2010 -2013).Setting -University teaching hospital.Animals -Client-owned healthy cats enrolled in a blood donation program.Interventions -None.Measurements and Main Results -Blood collection for transfusion was performed 115 times from 32 cats. Seventy donation events were in unsedated cats and 45 in sedated cats. For each collection, the anticipated blood volume to be collected, actual blood volume collected, sedation protocol, and any UEs in the peri-donation period were recorded. There were 6 categories of UEs: movement during donation, donor anxiety, inadequate collected blood volume, jugular vessel-related UEs, additional sedation requirement, and cardiorespiratory distress. Fisher's exact test was used to compare the frequency of UEs between sedated and unsedated cats. Unexpected events were recorded in 54 of 115 collections. In the donor population, movement was reported as an UE in 0 cats that donated under sedation and 24/70 (34.3%) cats that donated without sedation (P<0.001). Donor anxiety occurred in 2/45 (4.4%) cats that donated under sedation and 14/70 (20.0%) cats that donated unsedated (P=0.014). Unsedated donation did not increase the likelihood of inadequate donation volume, jugular vessel-related UEs, or cardiorespiratory distress. Eight of 45 (17.8%) sedated donations required additional sedation.Conclusions -Movement during donation and signs of donor anxiety were more frequent in unsedated cats. These were considered minor issues, expected in unsedated cats being gently restrained. Blood collection from unsedated feline donors is a viable alternative to sedated donation. Abbreviations UE -unexpected event

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Retrospective evaluation of unexpected events during collection of blood donations performed with and without sedation in cats (2010–2013)

Doolin

Chan

Adamantos

et al. 2017

J Vet Emergen Crit Care

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“…There are various sedation and anesthesiologic protocols for feline blood donation . We chose an association of alfaxalone, midazolam, and butorphanol.…”

Section: Discussionmentioning

confidence: 99%

“…There are various sedation and anesthesiologic protocols for feline blood donation. 3,18,[25][26][27] We chose an association of alfaxalone, midazolam, and butorphanol. In our study, the chosen protocol allowed a In both human and veterinary medicine, bacterial contamination of blood products is still the most prevalent infectious risk in transfusion medicine.…”

Section: Discussionmentioning

confidence: 99%

In vitro assessment of quality of citrate‐phosphate‐dextrose‐adenine‐1 preserved feline blood collected by a commercial closed system

Crestani

Stefani

Carminato

et al. 2018

Veterinary Internal Medicne

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BackgroundOptimal procedure for storage of feline blood is needed. Open‐collection systems have been employed in feline medicine, thus limiting the possibility for storage.ObjectivesTo evaluate indicators of quality of feline blood stored for 35 days at +4°C in a closed‐collection system specifically designed for cats.AnimalsEight healthy adult European domestic shorthair cats with a weight of 5‐6.8 kg.MethodsThis is a case series study. A bacteriological test, CBC, blood smear, pH, osmotic fragility, 2,3‐diphosphoglycerate (2,3‐DPG), and adenosine triphosphate (ATP) measurement were performed weekly on whole blood (WB) units from day 1 to day 35 after donation. The hemolysis index, lactate and potassium concentrations, prothrombin time (PT), activated partial thromboplastin time (aPTT), and fibrinogen were measured on plasma aliquots.ResultsOne out of eight blood units (BUs) had bacterial growth (Serratia marcescens) at day 35. No significant differences were found regarding CBC, morphology, pH, and osmotic fragility. Despite high inter‐individual variability and low starting levels, significant decreases in the mean concentrations of 2,3‐DPG (T0 1.99 mmol/g Hb, SD 0.52, T35 1.25 mmol/g Hb, SD 1.43; P = .003) and ATP (T0 1.45 mmol/g Hb, SD 0.71, T35 0.62 mmol/g Hb, SD 0.51; P < .001) were detected during the study, as opposed to an increase in hemolysis (T0 0.11 mmol/L, SD 0.07, T35 0.84 mmol/L, SD 0.19; P < .001), lactate (T0 3.30 mmol/L, SD 0.86, T35 13.36 mmol/L, SD 2.90; P < .001), and potassium (T0 3.10 mmol/L, SD 0.21, T35 4.12 mmol/L, SD 0.35; P < .001) concentrations.Conclusions and Clinical ImportanceThe commercial BU kit is appropriate for blood collection and conservation of WB in cats. The maintenance of WB quality indicators during storage is essential for future improvements of feline transfusion medicine.

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“…One study using sevoflurane (SEV) anesthesia investigated the effect of blood collection on vital signs and oscillometric blood pressure in feline blood donors, and determined that 50 mL of blood could safely be collected from healthy cats weighing more than 5 kg, but with a noticeable decrease in heart rate, blood pressure, and PCV . Another study compared 2 anesthetic protocols for feline blood collection including intramuscular ketamine‐midazolam‐butorphanol and inhalant SEV, and determined that cats anesthetized with SEV had a faster return to normal behavior . Importantly, hypotension was experienced by nearly all cats; therefore, IV access and blood pressure monitoring was recommended by the authors for all anesthetized feline blood donors .…”

Section: Discussionmentioning

confidence: 99%