Comparison of two automated assays of BTM (CTX and P1NP) and reference intervals in a Danish population

Jørgensen, Niklas Rye; Møllehave, Line Tang; Hansen, Young Bae Lee; Quardon, N.; Lylloff, Louise; Linneberg, Allan

doi:10.1007/s00198-017-4026-z

Cited by 57 publications

(36 citation statements)

References 29 publications

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“…However, the actual status of bone turnover in OA remains unclear and the few studies on bone turnover markers in OA are conflicting showing either reduced or increased CTX and unchanged PINP . Our data indicated that bone resorption (CTX) was low to low normal (mean: 269 ng/L) compared to the reference interval established by Jorgensen et al, while bone formation (PINP) was within normal range (mean: 42.5 µg/L).…”

Section: Discussioncontrasting

confidence: 46%

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

et al. 2019

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Exercise is recommended as first‐line treatment to reduce pain and improve physical function in patients with hip osteoarthritis, but the mechanism behind the effect remains unknown. Blood and urine were collected at baseline and after 4 months of exercise from 60+‐year‐old persons (n = 39) with hip osteoarthritis included in a randomized controlled trial comparing the effects of strength training (ST), Nordic Walking (NW), and unsupervised home‐based exercise (control). We measured biomarkers of bone (N‐terminal propeptide of type I collagen, C‐telopeptide of type I collagen, sclerostin, receptor activator of nuclear factor kappa‐B ligand, and osteoprotegerin) and cartilage (C‐telopeptide of type II collagen (CTX‐II), cartilage oligomeric matrix protein, and N‐terminal propeptide of type III collagen). Sclerostin levels decreased independent of the type of training. There was significant interaction between type of training and change in CTX‐II level. When combining the supervised groups (NW and ST), both CTX‐II and sclerostin level were decreased in the supervised training group, while CTX‐II and sclerostin were unchanged in the control group. In conclusion, CTX‐II and sclerostin level were reduced by 4 months of supervised training, suggesting that certain types of exercise affect cartilage and bone, potentially contributing to beneficial effects of exercise in patients.

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Section: Discussioncontrasting

confidence: 46%

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

et al. 2019

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“…Thus, the decrease could be an age-related phenomenon, or due to the change of assays. It is worth noting that our follow-up CTX values are at the very low end of the newly suggested normal range for a Danish population (41) .…”

Section: Calcium and Bone Turnover Parametersmentioning

confidence: 53%

Bone mineral density and markers of bone turnover and inflammation in diabetes patients with or without a Charcot foot: An 8.5-year prospective case-control study

Jansen

Christensen

Bülow

et al. 2018

Journal of Diabetes and its Complications

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“…The present study focused on bone metabolism indicators in patients of different age and gender using HIS data from one hospital, providing mathematical modeling to assist the future study of age and gender in disease research. Although multiple studies have been published that provide a reference for differences in children and adolescents [2][3][4][5][6][7][8], those studies did not provide a precise breakdown of age and gender, namely at what patient age does parameters require precise matching and which age does they not. Researchers believe that age matching should be performed on all subjects in disease control research, but strict age-matching substantially increases the cost and di culty of conducting the study.…”

Section: Discussionmentioning

confidence: 99%

Correlation between bone turnover and metabolic markers with age and gender: a cross-sectional study of hospital information system data

Shao

Zhou

Yuan

et al. 2020

Preprint

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Background: Bone turnover and metabolic indicators are related to age and gender. Age and gender should be matched in subjects in disease control research of bone turnover and metabolism, but strict matching of gender and age increases the difficulty and cost of the research. Therefore, the aim of this study was to solve it is necessary to strictly match age and gender in clinical research in bone metabolism.METHODS: A cross-sectional study was conducted from the data were extracted from the HIS of ZhuJiang Hospital. Data relating to seven bone turnover and metabolic indicators from 1036 patients between January 2018 and October 2019 were analyzed.RESULTS: P1NP, β-CTx and 25(OH)D were significant different in individuals younger than 20 years of age. ALP was significantly higher in those under 20 years of age and lower at age 20-39 compared with other age groups. The concentrations of Ca and P were different among the groups aged 0-19, 20-39, and 40-59 years of age groups but exhibited no difference above 60 years of age. PTH expression was not dependent on age. P1NP, β-CTx and PTH concentrations were not significantly different between the genders within the same age group. ALP was significantly different between genders within the age range 20-59 years. Ca and 25(OH)D were significantly different between the genders for those older than 60. Serum P was significantly different in the two genders for those aged 40-79. Patients received both alfacalcidol and calcium treatment differently from the others in P1NP, β-CTx, Serum Ca, P and ALP.CONCLUSION: P1NP and β-CTx were highly correlated with age. If these two indictors require analysis in a case control study, the patients and controls should be strictly matched by age under 20 years. The demarcation point for ALP was 40 years of age. Ca and P were strongly recommended strict matching according to age in disease research. The difference in P1NP, β-CTx, 25(OH)D and ALP between genders depends on age differences. Medication history should be considered in bone turnover and metabolic clinical research.

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Comparison of two automated assays of BTM (CTX and P1NP) and reference intervals in a Danish population

Cited by 57 publications

References 29 publications

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

Bone mineral density and markers of bone turnover and inflammation in diabetes patients with or without a Charcot foot: An 8.5-year prospective case-control study

Correlation between bone turnover and metabolic markers with age and gender: a cross-sectional study of hospital information system data

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