Comparison of two chemotherapy-induced peripheral neuropathy measurement approaches in children

Gilchrist, Lewayne D.; Marais, Lisa; Tanner, Lynn

doi:10.1007/s00520-013-1981-6

Cited by 61 publications

(66 citation statements)

References 22 publications

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“…However, until date there is no universally accepted tool for diagnosing chemotherapyinduced peripheral neuropathy in children and several scales (including or not electrodiagnostic studies) have been used to detect this complication in children receiving chemotherapy (12,27,28). Some examples are: the total neuropathy scale (TNS), clinical neuropathy scale, and the modified neuropathy scale.…”

Section: Study Limitationsmentioning

confidence: 99%

“…Some examples are: the total neuropathy scale (TNS), clinical neuropathy scale, and the modified neuropathy scale. Recently, the modified pediatric scale for total neuropathy (ped-mTNS) was validated as a variant of TNS (for not including electrodiagnostic studies), and has been considered as a reliable and valid measure for detecting CIPN in children with cancer and leukemia (27,28). Moreover, it has been also reported that sensitivity to detect CIPN with this scale is greater than with previous ones.…”

Section: Study Limitationsmentioning

confidence: 99%

“…Moreover, it has been also reported that sensitivity to detect CIPN with this scale is greater than with previous ones. For this reason, we used in present research the Ped-mTNS wich consisted of three sets of questions about sensory symptoms, pain, motor function and autonomic function, as well as a five-part neurological examination that includes light touch explored by monofilament, biotensor vibration, pin-prick sensitivity, distal force through manual muscle examination (performed on interossei, wrist extensors, extensor digitorum muscle and ankle dorsiflexors), and deep tendon reflexes (27,28).…”

Section: Study Limitationsmentioning

confidence: 99%

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Chemotherapy-Induced Peripheral Neuropathy in a Subpopulation of Mexican Pediatric Patients with Acute Lymphoblastic Leukemia

et al. 2017

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Background: Chemotherapy-induced peripheral neuropathy (CIPN) is frequent in children with acute lymphoblastic leukemia (ALL). Neurological manifestations can be grouped into one of the three functional divisions of the peripheral nervous system (PNS): sensory, motor and autonomic. One of the chemotherapeutic agents used in ALL is vincristine which has been associated with neuropathy in these children. This type of neuropathy can be transient but also leave permanent sequels that decrease patient's quality of life. Objectives: To know the frequency and type of neuropathy induced by chemotherapy in a subpopulation of Mexican pediatric patients with acute lymphoblastic leukemia. Methods: A cross-sectional study was conducted. There were included all pediatric patients with ALL diagnosed de novo from 2010 to December 31, 2013 who met the selection criteria. Descriptive statistics were used to determine the frequency and type of CIPN and information was described according to different clinical variables, type of treatment, risk classification, and ALL subtype according to the immunophenotype. Results: A total of 32 patients with acute lymphoblastic leukemia were included, mainly of early pre-B immunophenotype (93.8%), being 59.4% classified as high risk patients at the time of diagnosis. CIPN of sensory type was 78.1%, motor 34.3% and autonomic 40.6%. A significant proportion of patients (46.9%) were examined during maintenance phase. Conclusions: To our knowledge, this is the first study to report the frequency and type of CIPN in a subpopulation of Mexican children with acute lymphoblastic leukemia. Frequency of CIPN was higher than that reported in other populations. By considering that prognosis of a patient presenting CIPN could be considered as favorable after treatment suspension (in most cases), it is not always reversible and affects patient's quality of life. Therefore, it is necessary for all patients with ALL to be periodically monitored during treatment through neurological examination for detecting and immediately initiating their rehabilitation treatment.

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Section: Study Limitationsmentioning

confidence: 99%

Section: Study Limitationsmentioning

confidence: 99%

Section: Study Limitationsmentioning

confidence: 99%

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Chemotherapy-Induced Peripheral Neuropathy in a Subpopulation of Mexican Pediatric Patients with Acute Lymphoblastic Leukemia

et al. 2017

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“…Forty-seven full text articles were screened for full inclusion and exclusion criteria and 42 were excluded; 4 were not conducted with pediatric patients, 17 did not include patient-report, 12 were conference proceedings, and 6 were duplicate articles. A total of 5 full text articles met eligibility criteria and were included [6, 8, 12–14]. Figure 1 demonstrates the flow for article identification and selection.…”

Section: Resultsmentioning

confidence: 99%

“…In many clinical studies, the Common Terminology Criteria for Adverse Events (CTCAE) are used to report toxicities, but they have been shown to under-report the incidence of CIPN by up to 40 % [6–8]. Comprehensive clinical neurological exams tend to be poorly reproducible, inconsistent, or incomplete in their assessment of CIPN [7].…”

Section: Introductionmentioning

confidence: 99%

A systematic review of patient-reported outcome measures of neuropathy in children, adolescents and young adults

Johnston

Sung

Stark

et al. 2016

Support Care Cancer

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Purpose Peripheral neuropathy is an important, yet poorly studied, side effect of pediatric cancer treatment. There are many measures of patient-reported peripheral neuropathy in adults but very few in children. We aimed to systematically review and summarize reliable and valid patient-reported peripheral neuropathy scales used in pediatrics. Methods Four major electronic databases (Medline, Embase, EBSCO Host in Cumulative Index to Nursing and Allied Health Literature, and PsycINFO) were reviewed for studies that measured peripheral neuropathy in pediatric patients. Studies eligible for inclusion were those that described use of any patient-reported scale of peripheral neuropathy among children, adolescents, and young adults with any underlying diagnosis (not limited to cancer). Results From a total of 765 articles retrieved, 5 met eligibility criteria and were included. One was a neuropathy symptom score used in patients with diabetes, and the remaining four were in oncology patients and all were based on the total neuropathy score. All involved objective assessments conducted by trained professionals; none relied purely on patient report. Conclusions There are no validated instruments that consist solely of a patient-reported outcome measure of neuropathy in pediatrics and adolescents. Because the clinical evaluation of neuropathy requires specialized training, it is not generalizable in large studies conducted in many diverse institutions. Future studies should validate adult patient-reported neuropathy scales in pediatric and adolescent populations, or develop novel instruments designed for this population.

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Association of Exercise Intolerance With Emotional Distress, Attainment of Social Roles, and Health-Related Quality of Life Among Adult Survivors of Childhood Cancer

Hayek¹,

Brinkman

Plana

et al. 2020

JAMA Oncol

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IMPORTANCEExercise intolerance is associated with increased risk for morbidity and mortality in childhood cancer survivors. However, an association between exercise intolerance and psychosocial outcomes has not been fully explored.OBJECTIVE To examine the associations between exercise intolerance and emotional distress, attainment of social roles, and health-related quality of life in childhood cancer survivors. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional study including 1041 adult survivors of childhood cancer and 286 community controls in the St Jude Lifetime Cohort was conducted at St Jude Children's Research Hospital. The study was performed from April 1, 2012, to March 15, 2020.EXPOSURES Exercise intolerance was defined as relative peak oxygen uptake less than 85% of age-and sex-estimated levels from maximal cardiopulmonary exercise testing. MAIN OUTCOMES AND MEASURESEmotional distress was measured with the 18-item Brief Symptom Inventory-18, which includes overall Global Severity Index and depression, anxiety, and somatization subscales. Participants with T scores greater than or equal to 63 were classified as having elevated levels of distress. Social attainment was evaluated using patient-reported educational, employment, and marital status. Health-related quality of life was examined with the Medical Outcomes Survey Short Form-36. Participants with T scores less than or equal to 40 were classified as reporting poor health-related quality of life. RESULTSOf the 1041 participants, 528 were women (50.7%). The prevalence of exercise intolerance among survivors (mean [SD] age, 35.5 [9.2] years) was higher than that among controls (age, 34.5 [10.0] years) (survivors: 634 [60.9%] vs controls: 75 [26.2%], P < .001). After adjusting for age at diagnosis and cardiopulmonary exercise testing, sex, race/ethnicity, smoking, physical activity, and exercise intolerance were associated with an increased risk for anxiety (prevalence rate ratio [PRR], 1.95; 95% CI, 1.20-3.16), somatization (PRR, 1.86; 95% CI, 1.23-2.80), and unemployment (PRR, 1.76; 95% CI, 1.23-2.52); an inverse association was noted with having a college degree (PRR, 0.67; 95% CI, 0.50-0.88). Exercise intolerance was associated with an increased the risk for scoring less than or equal to 40 on the physical component summary of the Medical Outcomes Survey Short Form-36 (PRR, 3.69; 95% CI, 2.34-5.84). These associations persisted when either cancer treatment exposures or chronic health conditions were added to the model. CONCLUSIONS AND RELEVANCEThe findings of this study suggest that exercise intolerance is independently associated with emotional distress, attainment of social roles, and health-related quality of life of long-term survivors of childhood cancer. The results also suggest that improving physiologic capacity may benefit general health and wellness, as well as emotional health, ability to participate in social roles, and health-related quality of life.

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Comparison of two chemotherapy-induced peripheral neuropathy measurement approaches in children

Abstract: Prospective measures of CIPN using the ped-mTNS identified a far greater proportion of subjects with peripheral neurotoxicity as compared to CTCAE v3.0 sensory and motor neuropathy ratings, and thus we recommend the use of a specific measure of CIPN such as the ped-mTNS.

Cited by 61 publications

References 22 publications

Chemotherapy-Induced Peripheral Neuropathy in a Subpopulation of Mexican Pediatric Patients with Acute Lymphoblastic Leukemia

Chemotherapy-Induced Peripheral Neuropathy in a Subpopulation of Mexican Pediatric Patients with Acute Lymphoblastic Leukemia

A systematic review of patient-reported outcome measures of neuropathy in children, adolescents and young adults

Association of Exercise Intolerance With Emotional Distress, Attainment of Social Roles, and Health-Related Quality of Life Among Adult Survivors of Childhood Cancer

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