Comparison of two detector systems for cone beam CT small animal imaging: a preliminary study

Yang, Meng; Shaw, Chris C.; Liu, Xinming; Altunbaş, M.; Wang, Tianpeng; Chen, Lingyun; Tu, Shu-Ju; Kappadath, S. Cheenu; Lai, Chao Jen

doi:10.1117/12.656690

Cited by 5 publications

(5 citation statements)

References 22 publications

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“…The whole imaging unit is completely shielded in a desktop housing. SkyScan 1076 is a small-scale cone beam CT unit [1][2][3][4] and its scanning geometry is circular as shown in Fig. 1.…”

Section: Methodsmentioning

confidence: 99%

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Feasibility of using the micro CT imaging system as the conformal radiation therapy facility for small animals

Tu¹,

Hsieh²,

Chao³

et al. 2009

SPIE Proceedings

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In recent years, there has been an increasing number of integration for using the micro CT scanners, either home-built bench-top or commercially made, as the small animal radiation therapy irradiator in several research groups. In this paper, we study the x-ray beam physics such as the percentage depth dose distribution and their dose conformity characteristics using Monte Carlo simulation method for a series of photon energy levels often found in the current commercial micro CT imaging systems. Micro CT scanners have been one of the key imaging modalities in the current state-of-the-art molecular imaging techniques and their applications in various biomedical research areas have been increasing tremendously in recent years due to the ultra-high image quality. Tumor growth development and the corresponding therapeutic response in the small animal model study can be evaluated by a micro CT imaging system. In the most current advanced commercially available micro CT units, the nominal spatial resolution is typically at the scale of 10.0 m μ or less. In current research trend, there have been an increasing number of investigations for the applications of x-ray units to organ-specific and whole-body radiation in dedicated small animal model study. In particular, scientists have identified that the integrated micro CT imagers can be commissioned as the dual-purpose unit for the high spatial resolution image acquisition and radiation delivery. As we all realized that small animal models are important and critical in several studies of experimental (or pre-clinical) radiation therapy research. In this paper, a Monte Carlo code (Penelope) was used to calculate the percentage depth dose distributions at different photon energy levels. Also the corresponding iso-dose contour curves were computed and plotted from the circular CT scanning geometry to study the desired dose conformity property. We note that the selected photon energy range that is included in this work is often included in the current commercial micro CT systems.

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“…The whole imaging unit is completely shielded in a desktop housing. SkyScan 1076 is a small-scale cone beam CT unit [1][2][3][4] and its scanning geometry is circular as shown in Fig. 1.…”

Section: Methodsmentioning

confidence: 99%

“…(1) It is a translational research and the results can improve our tumor models in human. (2) It is an integration research between molecular imaging technology and radiation therapy. The final results can lead us to a perfect realization of imageguided irradiation in small animal models.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of using the micro CT imaging system as the conformal radiation therapy facility for small animals

Tu¹,

Hsieh²,

Chao³

et al. 2009

SPIE Proceedings

Self Cite

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“…A key advantage of CT is its high spatial resolution, 12 to 50 μm (Weissleder, 2002;Meng, 2006) which is needed to visualize fine anatomical details. CT can also be combined with functional imaging technologies that provide dynamic and metabolic information.…”

Section: Ct/microct and Mini-ctmentioning

confidence: 99%

Imaging from anatomic to molecular and atomic resolution scales: A review

Kamweru¹

2021

Afr. J. Biotechnol.

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Imaging may be referred to as the 'eyes of science' as it provides scientists with highly informative multi-dimensional and multi-parameter data usually invisible to the naked eye. As instrumentation technologies and genetic engineering advances, it's possible in modern times to observe and image highly dynamic biochemistry processes. This paper reviews positron emission tomography (PET), magnetic resonance imaging (MRI), computed tomography (CT), ultrasound, visible light microscopy, bioluminescence (BLI) and fluorescence mediated tomography (FMT) imaging techniques, highlighting the principles behind the operation of each technique, their major strengths and drawbacks. With the enhancement of the existing techniques and evolution of new ones, the future possibility of refined view of systems invisible to naked human eye is promising. More so is when two or more techniques are combined in biological systems analysis.

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“…A key advantage of CT is its high spatial resolution, 12 – 50 μm [ 29 , 70 ], which is needed to visualize fine anatomical details. CT can also be combined with functional imaging technologies that provide dynamic and metabolic information.…”

Section: Ct/microctmentioning

confidence: 99%

A review of imaging techniques for systems biology

et al. 2008

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This paper presents a review of imaging techniques and of their utility in system biology. During the last decade systems biology has matured into a distinct field and imaging has been increasingly used to enable the interplay of experimental and theoretical biology. In this review, we describe and compare the roles of microscopy, ultrasound, CT (Computed Tomography), MRI (Magnetic Resonance Imaging), PET (Positron Emission Tomography), and molecular probes such as quantum dots and nanoshells in systems biology. As a unified application area among these different imaging techniques, examples in cancer targeting are highlighted.

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Comparison of two detector systems for cone beam CT small animal imaging: a preliminary study

Cited by 5 publications

References 22 publications

Feasibility of using the micro CT imaging system as the conformal radiation therapy facility for small animals

Feasibility of using the micro CT imaging system as the conformal radiation therapy facility for small animals

Imaging from anatomic to molecular and atomic resolution scales: A review

A review of imaging techniques for systems biology

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