Comparison of two devices for measuring exercise transcutaneous oxygen pressures in patients with claudication

Urban, Marie; Signolet, Isabelle; Ribas, Christophe Colas; Feuilloy, Mathieu; Ábrahám, Pierre

doi:10.1024/0301-1526/a000454

Cited by 16 publications

(18 citation statements)

References 9 publications

(10 reference statements)

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“…Two experimental studies compared photo-optical TCpO2 directly with standard electro-chemical TCpO2 and found comparative results. However, photo-optical probes tend to demonstrate higher absolute TCpO2 values [ 10 , 16 ]. Our findings also suggest that photo-optical probes, in contrast to electro-chemical probes, provide higher TCpO2 values.…”

Section: Discussionmentioning

confidence: 99%

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Photo-Optical Transcutaneous Oxygen Tension Measurement Is of Added Value to Predict Diabetic Foot Ulcer Healing: An Observational Study

Leenstra

Kleijn

Kuppens

et al. 2020

JCM

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Currently, transcutaneous oxygen tension measurement (TCpO2) is the most favorable non-invasive test for diabetic foot ulcer (DFU) healing prognosis. Photo-optical TCpO2 is novel, less time-consuming and more practical in use compared to regular electro-chemical TCpO2. We prospectively investigated the clinical value of photo-optical TCpO2 to predict DFU healing. Patients with suspected DFU undergoing conservative treatment underwent an ankle pressure, toe-pressure and photo-optical TCpO2 test. The primary endpoint was DFU wound healing at 12 months. Based on their clinical outcome, patients were divided into a DFU healing and DFU non-healing group. Healing was defined as fully healed ulcers and non-healing as ulcers that deteriorated under conservative treatment or that required surgical amputation. Differences between groups were analyzed and an optimal TCpO2 cut-off value was determined. In total, 103 patients were included, of which 68 patients (66%) were classified as DFU healing. The remaining 35 patients (34%) had deteriorated ulcers, of which 29 (83%) eventually required surgical amputation. An optimal TCpO2 cut-off value of 43 mmHg provided a sensitivity, specificity and odds ratio of 0.78, 0.56 and 4.4, respectively. Photo-optical TCpO2 is an adequate alternative tool to validate the vascular status of the lower extremity indicating healing prognosis in patients with DFU. Therefore, we recommend that photo-optical TCpO2 can be safely coapplied in clinical practice to assist in DFU treatment strategy.

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Section: Discussionmentioning

confidence: 99%

“…Current TCpO2 measurement is conducted with an electro-chemical “Clark-electrode”, of which the technical details are explained elsewhere [ 9 ]. Recently, a novel photo-optical TCpO2 device has been introduced [ 10 ]. Photo-optical TCpO2 is based on the principle of the interaction between light and matter.…”

Section: Introductionmentioning

confidence: 99%

Photo-Optical Transcutaneous Oxygen Tension Measurement Is of Added Value to Predict Diabetic Foot Ulcer Healing: An Observational Study

Leenstra

Kleijn

Kuppens

et al. 2020

JCM

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“…We used PeriFlux 6000 (Perimed AB, Järfälla-Stockholm, Sweden). The temperature of all probes was 44.5 °C, to allow maximal local vasodilatation, thereby decreasing the arterial to skin pressure gradient, according to what was previously reported by Urban et al [20]. …”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Effects of Mesoglycan on Some Markers of Endothelial Damage and Walking Distance in Diabetic Patients with Peripheral Arterial Disease

Derosa

D’Angelo

Romano

et al. 2017

IJMS

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Abstract:The aim of this study was to evaluate the variation of some parameters involved in peripheral artery disease progression in diabetic patients with peripheral artery disease after six months of mesoglycan. We enrolled 64 Caucasian, type 2 diabetic patients, with stage IIa peripheral artery disease. They were randomized to mesoglycan (Prisma ® ), 50 mg twice a day, or placebo, for six months. We evaluated: glycemic control, metalloproteinase-2, and -9 (MMP-2, and -9), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion protein-1 (sVCAM-1), interleukin-6 (IL-6), soluble E-selectin (sE-selectin), high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and plasminogen activator inhibitor-1 (PAI-1). We recorded a decrease of MMP-2, MMP-9, sE-selectin, TNF-α, sVCAM-1, and IL-6 compared to baseline, and to placebo in the group treated with mesoglycan. Regarding sICAM-1, and hs-CRP, instead, we recorded a decrease with mesoglycan only compared to baseline. Preliminary results seem to suggest an improvement of pain free walking distance with mesoglycan in 18 patients both compared to baseline and to placebo, even if data should be taken cautiously. Our study showed that supplementation with mesoglycan improved endothelial dysfunction in type 2 diabetic patients with peripheral artery disease. Regarding the preliminary data suggesting also a slight improvement of clinical parameters such as pain free walking distance, more data and a bigger sample of patients are necessary to better verify this aspect.

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“…Recently, a novel photo-optical approach of TCpO2 measurement (pTCpO2), has been introduced. 1 This photo-optical technique defines the partial oxygen pressure based on a light-emitting-diode and photodiode. The underlying mechanism of this technique is explained elsewhere.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Photo-Optical Transcutaneous Oxygen Tension Measurement During Revascularization of the Lower Extremity

Leenstra

Meerkerk

Conte

et al. 2021

Annals of Vascular Surgery

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Objectives: A novel approach in the evaluation of peripheral arterial disease is the photo-optical oxygen tension measurement (pTCpO2). This modality is suggested to be more practical in use in comparison to standard electro-chemical oxygen tension measurement. Hence, pTCpO2 might be of added value to evaluate revascularization of the lower extremities periprocedural. We conducted a preliminary feasibility study to analyze the potential of pTCpO2 dur ing revascular ization. Methods: Ten patients scheduled for revascularization of the lower extremities were enrolled. pTCpO2 values of the affected lower extremity were measured pre-operatively, during revascularization and after revascularization. Results were compared to the pre-and postoperative ankle-brachial index (ABI) and to perioperative angiography. Primary endpoint was the feasibility of perioperative pTCpO2 measurement. Secondary endpoints were concordance between pTCpO2, ABI, angiography and clinical outcome. Results: Two out of twelve measurements were unsuccessful. Eight out of ten patients experienced significant clinical improvement and pTCpO2 increase. Two patients that did not experience clinical improvement corresponded with no changes in intraoperative angiography and without increase in ABI or pTCpO2. A significant and strong correlation was found between prior and after revascularization ABI and pTCpO2 measurements ( r = 0.82 P = 0.04). Conclusions: Photo-optical transcutaneous oxygen tension measurement may serve as an intraoperative tool to evaluate the success of revascularization. pTCpO2 could be an alternative for the ABI to determine the success of lower extremity revascularization.

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Comparison of two devices for measuring exercise transcutaneous oxygen pressures in patients with claudication

Abstract: Forty seven patients with arterial claudication ( 65 ± 7 years) performed a treadmill test with 5 probes each of the electro-chemical and photo-optical devices simul-

Cited by 16 publications

References 9 publications

Photo-Optical Transcutaneous Oxygen Tension Measurement Is of Added Value to Predict Diabetic Foot Ulcer Healing: An Observational Study

Photo-Optical Transcutaneous Oxygen Tension Measurement Is of Added Value to Predict Diabetic Foot Ulcer Healing: An Observational Study

Evaluation of the Effects of Mesoglycan on Some Markers of Endothelial Damage and Walking Distance in Diabetic Patients with Peripheral Arterial Disease

Feasibility of Photo-Optical Transcutaneous Oxygen Tension Measurement During Revascularization of the Lower Extremity

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