Comparison of Two Fibrin Glues in Anastomoses and Skin Closure

Park, W.; Kim, W. H.; Lee, C. H.; Kim, D. Y.; Choi, Jae-Sung; Huh, Joseph; Sung, Hark-Mo; Kim, I. S.; Kweon, Oh‐Kyeong

doi:10.1046/j.1439-0442.2002.00468.x

Cited by 17 publications

(7 citation statements)

References 20 publications

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“…In an experimental study of renal vessel anastomoses, Park et al [3] compared two different products (Greenplast; Green Cross P.D. Company, Yongin, Korea vs. Tisseel; Baxter-Immuno AG, Vienna, Austria) and found that the two-component fibrin glues had similar effects on hemostatic modulation, mechanical barrier and adhesive outcomes, and no complications ensued after the use of either.…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy of different doses of fibrin sealant to reduce bleeding after total knee arthroplasty

Notarnicola¹,

Moretti²,

Martucci³

et al. 2012

Blood Coagulation &Amp; Fibrinolysis

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In recent years, the application of fibrin sealant has been shown to be efficacious in the management of intraoperative and postoperative hemostasis. We designed a prospective randomized controlled clinical trial to assess the efficacy of two different dosages of fibrin sealant (5 and 10 ml) in patients undergoing total knee arthroplasty, as compared with the untreated control group. A total of 90 patients entered the study, randomly assigned to one of the three groups: treatment with 5 ml fibrin sealant (30 patients), with 10 ml fibrin sealant (30 patients) or no treatment (30 patients). A statistically significant difference in the mean reduction of hemoglobin concentrations was found on the first postoperative day in the treated groups as compared with the controls: 5 ml fibrin sealant (2.6 mg/dl) and 10 ml fibrin sealant (2.5 mg/dl) vs. controls (3.7 mg/dl) (P = 0.024). The mean number of blood transfusions was significantly lower in the treated groups: 5 ml (0.5) and 10 ml (0.3) of fibrin sealant vs. controls (1) (P = 0.0019). Functional recovery was also better in the treated groups: on the seventh day, the joint ROM (range of motion) was statistically superior in the 5 ml group (96.5°) and 10 ml group (98.8°) as compared with the controls (75.5°) (P < 0.0001). This study supports the efficacy of administering fibrin sealant in the perioperative management of bleeding after total knee arthroplasty and shows that a 5 ml dosage yields a comparable outcome to the 10 ml dosage previously reported in the literature.

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Section: Introductionmentioning

confidence: 99%

Comparative efficacy of different doses of fibrin sealant to reduce bleeding after total knee arthroplasty

Notarnicola¹,

Moretti²,

Martucci³

et al. 2012

Blood Coagulation &Amp; Fibrinolysis

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“…The method of tissue adaptation is therefore limited by free moving space thus revealing conventional suturing unsuitable. Fibrin based adhesives or glues achieve insufficient tensile strength for suture replacement and are further limited by early resorption [10,11]. These products can be used as temporary sealants or hemostatic agents.…”

Section: Introductionmentioning

confidence: 99%

Solder doped polycaprolactone scaffold enables reproducible laser tissue soldering

et al. 2008

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Background and Objectives: In this in vitro feasibility study we analyzed tissue fusion using bovine serum albumin (BSA) and Indocyanine green (ICG) doped polycaprolactone (PCL) scaffolds in combination with a diode laser as energy source while focusing on the influence of irradiation power and albumin concentration on the resulting tensile strength and induced tissue damage. Materials and Methods: A porous PCL scaffold doped with either 25% or 40% (w/w) of BSA in combination with 0.1% (w/w) ICG was used to fuse rabbit aortas. Soldering energy was delivered through the vessel from the endoluminal side using a continuous wave diode laser at 808 nm via a 400 mm core fiber. Scaffold surface temperatures were analyzed with an infrared camera. Optimum parameters such as irradiation time, radiation power and temperature were determined in view of maximum tensile strength but simultaneously minimum thermally induced tissue damage. Differential scanning calorimetry (DSC) was performed to measure the influence of PCL on the denaturation temperature of BSA. Results: Optimum parameter settings were found to be 60 seconds irradiation time and 1.5 W irradiation power resulting in tensile strengths of around 2,000 mN. Corresponding scaffold surface temperature was 117.4 AE 128C. Comparison of the two BSA concentration revealed that 40% BSA scaffold resulted in significant higher tensile strength compared to the 25%. At optimum parameter settings, thermal damage was restricted to the adventitia and its interface with the outermost layer of the tunica media. The DSC showed two endothermic peaks in BSA containing samples, both strongly depending on the water content and the presence of PCL and/or ICG. Conclusions: Diode laser soldering of vascular tissue using BSA-ICG-PCL-scaffolds leads to strong and reproducible tissue bonds, with vessel damage limited to the adventitia. Higher BSA content results in higher tensile strengths. The DSC-measurements showed that BSA denaturation temperature is lowered by addition of water and/or ICG-PCL. Lasers Surg. Med. 40:716-725, 2008. ß

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“…An additional seven studies have been performed using animal models. [5][6][7][8][9][10][11] To our knowledge, no studies have evaluated ostomy creation using tissue adhesives. The present study thus features several IRB-mandated restrictions to ensure patient safety during ostomy creation, including using two sutures and an ostomy rod before tissue adhesives could be used alone.…”

Section: Uchino Ikeuchi Bando Sasaki Chohno Horio Takesuementioning

confidence: 99%

Ostomy creation with fewer sutures using tissue adhesives (cyanoacrylates) in inflammatory bowel disease: a pilot study

Uchino

Ikeuchi

Bando

et al. 2018

annals

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Introduction Fistula formation around the ostomy site is a stoma-related complication often requiring surgical intervention. This complication may be caused by sutures or may develop as a complication of inflammatory bowel disease. Before conducting a clinical trial, we set out to investigate the safety of ostomy creation with fewer sutures using tissue adhesives in this pilot study. Methods Patients with inflammatory bowel disease who required surgery with ostomy creation at the Hyogo College of Medicine between January 2014 and December 2015 were enrolled. Safety was assessed by evaluating the incidence of stoma-related complications. Ostomy was restricted to loop ileostomy and was created with two sutures and tissue adhesives. Results A total of 14 patients were enrolled. Mean body mass index was 18.9 ± 2.0 kg/m. There were no cases of ostomy retraction and no severe adverse events were observed. Conclusions This pilot study demonstrates that ostomy creation using tissue adhesives is safe. Although retraction and adverse events were not observed, even in patients with inflammatory bowel disease who generally exhibit delayed wound healing, the body mass index was extremely low in this series. This study does not strongly recommend ostomy creation with tissue adhesives; further studies are needed to clarify the efficacy and safety of the procedure.

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Comparison of Two Fibrin Glues in Anastomoses and Skin Closure

Cited by 17 publications

References 20 publications

Comparative efficacy of different doses of fibrin sealant to reduce bleeding after total knee arthroplasty

Comparative efficacy of different doses of fibrin sealant to reduce bleeding after total knee arthroplasty

Solder doped polycaprolactone scaffold enables reproducible laser tissue soldering

Ostomy creation with fewer sutures using tissue adhesives (cyanoacrylates) in inflammatory bowel disease: a pilot study

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