Comparison of two formulations of intravenous lipid emulsions in pediatric intestinal failure

Naik, Mamta; Lawrence, Alexandria; Davidson, Allison; Chapman, John; Ferguson, Dalya; Speer, Allison L.; Imseis, Essam

doi:10.1007/s00383-024-05674-4

Pediatr Surg Int

2024

DOI: 10.1007/s00383-024-05674-4

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Comparison of two formulations of intravenous lipid emulsions in pediatric intestinal failure

Mamta Naik,

Alexandria Lawrence,

Allison Davidson

et al.

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Parenteral lipid emulsions: the state of the art

Da Prat,

Caccialanza,

Cotogni

2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Several types of injectable lipid emulsions (ILEs) have become available for parenteral nutrition. The purpose of this review is to highlight the most recent and interesting articles in the field of ILEs. Recent findings Recent literature has compared ILEs in various clinical scenarios (e.g. abdominal surgery, chronic intestinal failure, critical illness, and preterm birth). Favorable clinical effects of ILEs containing fish oil have been observed in studies on surgical patients with Crohn's disease, critically ill patients, and patients with intestinal failure-associated liver dysfunction, whereas other trials have shown no clear benefit. Ongoing research is focused on finding novel strategies to reduce liver toxicity of ILEs, including the use of ‘artificial intelligence’ tools and liver organoids. Promising new applications for ILEs are emerging, including the prevention of neonatal hypoxic brain injury. Summary Although ILEs with the goal of reducing the levels of pro-inflammatory omega-6 fatty acids appear to confer some advantage in some settings (e.g. surgery), conclusive data on the superiority of one ILE over another are lacking. In particular, research is needed to compare different types of mixed-oil ILEs with each other and with pure fish oil ILEs.

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Parenteral lipid emulsions: the state of the art

Da Prat,

Caccialanza,

Cotogni

2024

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

View full text Add to dashboard Cite

show abstract

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Comparison of two formulations of intravenous lipid emulsions in pediatric intestinal failure

Cited by 1 publication

References 25 publications

Parenteral lipid emulsions: the state of the art

Parenteral lipid emulsions: the state of the art

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