Comparison of Two High-End Ultrasound Systems for Contrast-Enhanced Ultrasound Quantification of Mural Microvascularity in Crohn’s Disease

Zink, Fabian; Kratzer, Wolfgang; Schmidt, Stefan A.; Oeztuerk, Suemeyra; Mason, Richard; Porzner, Marc; Klaus, Jochen; Haenle, Mark Martin; Graeter, Tilmann

doi:10.1055/s-0034-1398746

Cited by 26 publications

(24 citation statements)

References 19 publications

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“…We therefore recommend that curve fitting quality should be reported alongside test results in future publications. Also, using low perfused tissue as a reference will cause high uncertainty of the final results [40].…”

Section: Discussionmentioning

confidence: 99%

“…However, based on the present findings within patient repeatability seems acceptable for the clinical use of CEUS in CD, especially when applying strict criteria for size and QoF. Lack of strict criteria or the use of a low perfused tissue as the reference tissue will lead to poor reproducibility [35,40]. We chose to restrict the inclusion of patients to those with moderate to severe disease activity based on clinical symptoms.…”

Section: P-valuementioning

confidence: 93%

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Dynamic Contrast-Enhanced Magnetic Resonance Enterography and Dynamic Contrast-Enhanced Ultrasonography in Crohn’s Disease: An Observational Comparison Study

Wilkens

Peters

Nielsen

et al. 2017

Ultrasound International Open

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Purpose e Cross-sectional imaging methods are important for objective evaluationof small intestinal inflammationinCrohn?sdisease(CD).The primary aim was to compare relative parameters of intestinal perfusion between contrast-enhanced ultrasonography (CEUS) and dynamic contrast-enhanced magnetic resonance enterography (DCE-MRE) in CD. Furthermore, we aimed at testing the repeatability of regions of interest (ROIs) for CEUS. Methods This prospective study included 25 patients: 12 females (age: 37, range: 19?66) with moderate to severe CD and a bowel wall thickness>3mm evaluated with DCE-MRE and CEUS. CEUS bolus injection was performed twice for repeatability and analyzed in VueBox?. Correlations between modalities were described with Spearman?s rho, limits of agreement(LoA) and intraclass correlation coefficient(ICC). ROIrepeatability for CEUS was assessed. Results s The correlation between modalities was good and very good for bowel wall thickness (ICC=0.71, P<0.001) and length of the inflamed segment (ICC=0.89, P<0.001). Moderate-weak correlations were found for the time-intensity curve parameters: peak intensity (r=0.59, P=0.006), maximum wash-in-rate (r=0.62, P=0.004), and wash-in perfusion index (r=0.47, P=0.036). Best CEUS repeatability for peak enhancement was a mean difference of 0.73?dB (95% CI: 0.17 to 1.28, P=0.01) and 95% LoA from ?3.8 to 5.3?dB. Good quality of curve fit improved LoA to ?2.3 to 2.8?dB. Conclusion The relative perfusion of small intestinal CD assessed with DCE-MRE and CEUS shows only a moderate correlation. Applying strict criteria for ROIs is important and allows for good CEUS repeatability

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Section: Discussionmentioning

confidence: 99%

Section: P-valuementioning

confidence: 93%

Dynamic Contrast-Enhanced Magnetic Resonance Enterography and Dynamic Contrast-Enhanced Ultrasonography in Crohn’s Disease: An Observational Comparison Study

Wilkens

Peters

Nielsen

et al. 2017

Ultrasound International Open

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“…Last but not least, additional ultrasound modalities, for instance, CEUS, which focuses on blood vessel delineation, would be meaningful. 19,37…”

Section: Discussionmentioning

confidence: 99%

Quantitative Analysis of Superb Microvascular Imaging versus Color-Coded Doppler Sonography for Preoperative Evaluation of Vascularization of Schwannomas

Kloth

Eissler

Schmidberger

et al. 2019

J Neurol Surg A Cent Eur Neurosurg

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Purpose Comparison of vascularization of schwannomas, benign peripheral nerve sheath tumors, using color-coded Doppler sonography (CCDS) and the Toshiba monochrome Superb Microvascular Imaging (mSMI) (Minato, Tokyo, Japan) technique. Methods In a retrospective single-center analysis, 16 patients were identified with histologically confirmed schwannomas. Between March and June 2018, all of them underwent ultrasonography using mSMI and CCDS before surgery. Schwannoma vascularization was quantitatively measured using ImageJ, an open platform for scientific image analysis. As the diagnostic gold standard, magnetic resonance imaging was mandatory. Results The mSMI and CCDS vascularization showed a moderate agreement between the techniques (κ = 0.5556; p = 0.0066). The quantitative visual assessment of the vascularization revealed no difference (25.3 ± 8.2 vs. 18.2 ± 3.8; p = 0.0532). Significant differences were found for the quantitative assessment of CCDS with ImageJ (26.8 ± 8.8 vs. 19.3 ± 2.8; p = 0.0368). However, in a subanalysis of highly vascularized schwannomas, mSMI revealed significant differences to slightly vascularized schwannomas (32.0 ± 8.2 vs. 21.3 ± 6.1; p = 0.0065) but not between moderately and slightly vascularized types (p = not significant). Conclusion The mSMI mode is qualitatively superior to conventional CCDS; however, quantitative analysis of the vascularization of schwannomas revealed no significant quantitative advantage for mSMI. Nevertheless, the mean ImageJ values showed a positive trend toward a better representation of the vascularization degree of schwannomas with mSMI.

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“…As mentioned in the introduction, only one study has previously addressed the variability of measurements between scanners [10]. They used the Vuebox software which analyzes time intensity curves.…”

Section: Discussionmentioning

confidence: 99%

“…Briefly summarized, differences in settings of the ultrasound scanner, patient characteristics, injection technique, ultrasound contrast behavior, presence of large vessels in the ROI, region selection and tissue motion are all factors that may introduce variability [5][6][7][8]. Studies with strict standardization criteria show promising results [9], while there is high variability and low reproducibility when attempts are made to compare different equipment [10].…”

Section: Introductionmentioning

confidence: 99%

Interobserver Variation of the Bolus-and-Burst Method for Pancreatic Perfusion with Dynamic – Contrast-Enhanced Ultrasound

Stangeland

Engjom

Mézl

et al. 2017

Ultrasound Int Open

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AbSTR Ac TPurpose Dynamic contrast-enhanced ultrasound (DCE-US) can be used for calculating organ perfusion. By combining bolus injection with burst replenishment, the actual mean transit time (MTT) can be estimated. Blood volume (BV) can be obtained by scaling the data to a vessel on the imaging plane. The study aim was to test interobserver agreement for repeated recordings using the same ultrasound scanner and agreement between results on two different scanner systems. Materials and MethodsTen patients under evaluation for exocrine pancreatic failure were included. Each patient was scanned two times on a GE Logiq E9 scanner, by two different observers, and once on a Philips IU22 scanner, after a bolus of 1.5 ml Sonovue. A 60-second recording of contrast enhancement was performed before the burst and the scan continued for another 30 s for reperfusion. We performed data analysis using MATLAB-based DCE-US software. An artery in the same depth as the region of interest (ROI) was used for scaling. The measurements were compared using the intraclass correlation coefficient (ICC) and Bland Altman plots.Results The interobserver agreement on the Logiq E9 for MTT (ICC = 0.83, confidence interval (CI) 0.46-0.96) was excellent. There was poor agreement for MTT between the Logiq E9 and the IU22 (ICC = − 0.084, CI − 0.68-0.58). The interobserver agreement for blood volume measurements was excellent on the Logiq E9 (ICC = 0.9286,) and between scanners (ICC = 0.86, CI = 0.50-0.97).Conclusion Interobserver agreement was excellent using the same scanner for both parameters and between scanners for BV, but the comparison between two scanners did not yield acceptable agreement for MTT. This was probably due to incomplete bursting of bubbles in some of the recordings on the IU22.

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Comparison of Two High-End Ultrasound Systems for Contrast-Enhanced Ultrasound Quantification of Mural Microvascularity in Crohn’s Disease

Cited by 26 publications

References 19 publications

Dynamic Contrast-Enhanced Magnetic Resonance Enterography and Dynamic Contrast-Enhanced Ultrasonography in Crohn’s Disease: An Observational Comparison Study

Dynamic Contrast-Enhanced Magnetic Resonance Enterography and Dynamic Contrast-Enhanced Ultrasonography in Crohn’s Disease: An Observational Comparison Study

Quantitative Analysis of Superb Microvascular Imaging versus Color-Coded Doppler Sonography for Preoperative Evaluation of Vascularization of Schwannomas

Interobserver Variation of the Bolus-and-Burst Method for Pancreatic Perfusion with Dynamic – Contrast-Enhanced Ultrasound

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