Comparison of two methods for the assessment of intra-erythrocyte magnesium and its determinants: Results from the LifeLines cohort study

Schutten, Joëlle C; Post, Adrian; Meer, Margriet van der; IJmker, Jan; Goorman, Frans; Danel, Richard M; Vervloet, Marc G.; Borst, Martin H. de; Touw, Daan; Bakker, Stephan J. L.

doi:10.1016/j.cca.2020.09.007

Cited by 3 publications

(6 citation statements)

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“…An early observational study already concluded that serum Mg does not reliably reflect intracellular or total body Mg content [ 6 ]. Considering that serum Mg comprises only a small fraction of total body Mg, various other methods of Mg measurement have been explored, among other intracellular Mg, i.e., erythrocyte or lymphocyte Mg, muscular Mg, and metabolic assessment through 24-hour (24-h) urinary excretion [ 1 , 16 , 17 , 18 ]. Somewhat contradicting the assumption that serum Mg does not adequately reflect total Mg content are findings from a Dutch population-based cohort study, where different methods of assessing intra-erythrocyte Mg correlated strongly with serum Mg levels as well as 24-h urinary excretion [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Considering that serum Mg comprises only a small fraction of total body Mg, various other methods of Mg measurement have been explored, among other intracellular Mg, i.e., erythrocyte or lymphocyte Mg, muscular Mg, and metabolic assessment through 24-hour (24-h) urinary excretion [ 1 , 16 , 17 , 18 ]. Somewhat contradicting the assumption that serum Mg does not adequately reflect total Mg content are findings from a Dutch population-based cohort study, where different methods of assessing intra-erythrocyte Mg correlated strongly with serum Mg levels as well as 24-h urinary excretion [ 17 ]. In turn, the lack of a consistent relation between Mg content of compartments and its serum concentration is exemplified by the observation that supplementing Mg does not necessarily change serum Mg concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Magnesium Administration in Chronic Kidney Disease

Vermeulen

Vervloet

2023

Nutrients

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Awareness of the clinical relevance of magnesium in medicine has increased over the last years, especially for people with chronic kidney disease (CKD), due to magnesium’s role in vascular calcification and mineral metabolism. The inverse association between serum magnesium and clinically relevant, adverse outcomes is well-established in people with CKD. Subsequent intervention studies have focused on the effect of magnesium administration, mainly in relation to cardiovascular diseases, mineral bone metabolism, and other metabolic parameters. The most commonly used routes of magnesium administration are orally and by increasing dialysate magnesium. Several oral magnesium formulations are available and the daily dosage of elemental magnesium varies highly between studies, causing considerable heterogeneity. Although data are still limited, several clinical studies demonstrated that magnesium administration could improve parameters of vascular function and calcification and mineral metabolism in people with CKD. Current clinical research has shown that magnesium administration in people with CKD is safe, without concerns for severe hypermagnesemia or negative interference with bone metabolism. It should be noted that there are several ongoing magnesium intervention studies that will contribute to the increasing knowledge on the potential of magnesium administration in people with CKD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magnesium Administration in Chronic Kidney Disease

Vermeulen

Vervloet

2023

Nutrients

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“…On the other hand, excessive consumption of magnesium from drugs containing Mg (laxatives or antacids) led to hypermagnesemia, hyperthyroidism, kidney failure, and liver failure. Therefore, it is important to maintain the stability of the balanced micronutrient magnesium content in the body (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…Magnesium has medicinal value as a general laxative, antacid (e.g. milk of magnesia), and to stabilize abnormal nerve excitation or spasm of blood vessels in conditions such as eclampsia (2).…”

Section: Introductionmentioning

confidence: 99%

“…..................................... .................................... Molar Absorptivity of Xylydil Blue-I (49.000 L M -1 cm -1 ) The calculation results of the two formulas were analyzed using the Paired T-12 test. The accuracy and precision analysis are calculated based on the deviation from repeated measurements of 3 times.RESULTSThis research begins by creating a calibration curve to get the liner value.Standard curve determination was performed with several concentrations(2,4,6,8 mg/dL).…”

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Chemometric Analysis of Serum Magnesium Calculations Using Mg-Xylidyl Blue-I Method Based on Molar Absorptivity

Kafesa

Lutfi

Wahyu

2021

IJMLST

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The concentration of magnesium is determined based on the absorbance of the Mg-Xylydil Blue-I complex solution use spectrophotometer. Based on the Lambert-Beer rule, the calculation of sample concentration is based on the formula A = Ԑ. b. C. Generally, the thickness of the cuvette (b) and the molar absorptivity (Ԑ) factor will be ignored because it is considered to have a fixed value, therefore the sample concentration is measured based on the ratio of the absorbance of the sample against the standard solution. However, the standard solution contains pure magnesium and has a different matrix than the sample matrix, so this condition can give analytical errors and lead to misinterpretation of the results. The purpose of this study was to determine the accuracy and the precision of serum magnesium calculation by the principle of the Mg- Xylydil Blue-I complex reaction based on molar absorptivity compared to the general method. This research uses comparative study design methods. The serum sample used was the patient's serum specimen who has a normal magnesium level. The results showed that the significance value of the paired t-test statistical was 0.000 (p < 0.05). The accuracy value (d%) of the calculation formula uses Ɛ is 0.00 and the precision value (CV%) is 0.53. While the accuracy value (d%) of the calculation formula without Ɛ is 0.00 and the precision value (CV%) is 0.38. Calculations based on molar absorptivity (Ɛ) can measure more significant serum magnesium than those calculated based on standard magnesium solutions.

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