Purpose. To investigate and compare the effects of 6-week self-management education (SME) and quadriceps strengthening exercises (QSE) on pain and disability in individuals with knee osteoarthritis (OA). Methods. A total of 79 (13 males, 66 females) consecutive patients with knee OA were randomised into SME and QSE groups. The SME group were taught modules of self-management once a week for 6 weeks, while the QSE group had supervised QSE thrice a week for 6 weeks. Pain intensity and physical function were assessed with the Visual Analogue Scale and Ibadan Knee/Hip Osteoarthritis Outcome Measure (IKHOAM) at baseline, week 6, and at the follow-up time points of the 1 st , 2 nd and 3 rd months. Results. The effects of both interventions were comparable (p > 0.005) during intervention and follow-up. During intervention, in both groups, pain intensity significantly decreased (p < 0.001, effect size = 0.603) and IKHOAM scores improved (p < 0.001, effect size = 0.540). There were significant time by group interaction effects during follow-up as pain intensity (p < 0.001, effect size = 0.085) did not change in the QSE group but further decreased in the SME group, IKHOAM scores (p = 0.005, effect size = 0.053) remained the same in the SME group while it decreased in the QSE group with respect to the end of intervention (6 th week). Conclusions. Supervised QSE and SME are both effective in reducing pain and disability in knee OA but improvements in the outcomes are better sustained with SME.