Comparison of two yttrium-90 regimens in inflammatory and osteoarthropathies.

Will, R.; Laing, B.A.; Edelman, J; Lovegrove, F.; Surveyor, Ivor

doi:10.1136/ard.51.2.262

Cited by 35 publications

(15 citation statements)

References 12 publications

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“…Therefore, scintigraphy should be used as a "baseline staging" examination for the patients in whom RA has been detected. Thereby the bone scintigraphy can be used to initiate RSO in a timely fashion before erosive destructive changes occur that reduce the success rate of RSO [2,3,7,14,31,32].…”

Section: Bone Scintigraphy For Initiating Rsomentioning

confidence: 99%

Radiosynoviorthesis (RSO): influencing factors and therapy monitoring

et al. 2008

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Section: Bone Scintigraphy For Initiating Rsomentioning

confidence: 99%

Radiosynoviorthesis (RSO): influencing factors and therapy monitoring

et al. 2008

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“…A reduction in blood flow can be demonstrated by scintigraphy,6 suggesting a rapid anti-inflammatory effect. The radioisotope yttrium-90 ( 90 Y), used to treat persistently inflamed joints since 1963, seems to produce effects at three months, lasting for up to a year 7. The duration of such an effect suggests an action on proliferating cells and pannus formation.…”

mentioning

confidence: 99%

Quantitative magnetic resonance imaging of the knee: a method of measuring response to intra-articular treatments

Creamer

Keen

Zananiri

et al. 1997

Annals of the Rheumatic Diseases

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Objectives-To investigate the potential of quantitative magnetic resonance imaging (MRI) to diVerentiate between therapeutically induced changes in inflammation and synovial proliferation in rheumatoid arthritis (RA) of the knee. Methods-MRI of the knee was performed on patients with RA before and one week after injection with corticosteroid (triamcinolone acetonide, TA group, n=9) and before, four, and 12 weeks after injection with yttrium-90 plus TA (TA+Y group, n=7). MRI scans were analysed by subjective visual grading by a trained observer and by computer aided quantitation for three features: synovial fluid volume, synovial pannus volume, and synovial enhancement after intravenous contrast agent. Results-All TA subjects improved clinically at one week but the eVects of TA+Y were more variable. TA significantly reduced synovial enhancement and eVusion volume, whereas TA+Y at 12 weeks tended to increase synovial enhancement and decrease pannus volume. Quantitative MRI values agreed well with subjective assessment of scans. Comparison of calculated change on MRI scan before and immediately after aspiration with actual volume aspirated showed high correlation (r=0.96). Conclusions-Quantitative MRI correlates with subjective visual assessment and, at least for synovial fluid, is accurate. MRI can diVerentiate actions of two therapeutic modalities on various pathological processes and is sensitive enough to detect change after one week. With the additional advantage of lack of observer bias, it will probably become a useful tool in the development and assessment of existing and novel treatments.

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“…Therefore, some previous studies involving only small patients numbers seem to have underestimated the effectiveness of RSO in these disorders. 10,15 RSO was only performed after synovitis had been proven by positive blood-pool scintigraphy. However, RSO was not equally beneficial in all patients, and the effectiveness of RSO may be influenced by the degree of synovitis, as well as the prerequisite joint destruction.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7][8] Whereas RSO may be an effective treatment in other disorders with concomitant synovitis, too, the outcomes of RSO have not yet been established in large numbers of patients with osteoarthritis, psoriasis arthritis, pigmental villonodular synovitis, or persistent effusions after joint replacement. [9][10][11][12][13][14][15] Aim The aim of this study was to evaluate the effectiveness of radiosynoviorthesis (RSO) in osteoarthritis and other disorders with concomitant synovitis versus rheumatoid arthritis by means of a standardized questionnaire. …”

Section: Introductionmentioning

confidence: 99%