Comparison of Two β-Alanine Dosing Protocols on Muscle Carnosine Elevations

Church, David D.; Hoffman, Jay R.; Varanoske, Alyssa N.; Wang, Ran; Baker, Kayla M.; Monica, Michael B. La; Beyer, Kyle S.; Dodd, Sarah J.; Oliveira, Leonardo P.; Harris, Roger C.; Fukuda, David H.; Stout, Jeffrey R.

doi:10.1080/07315724.2017.1335250

Cited by 41 publications

(48 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A recent investigation by Church et al. () demonstrated that a 2 week supplement duration of 12 g/day of BA increased intramuscular carnosine content to the same extent as 6 g/day taken for 4 weeks. In addition, the greater supplement dose was not associated with any greater risk for adverse effects (Church et al.…”

Section: Introductionmentioning

confidence: 95%

“…Most studies examining the beneficial effects of BA supplementation on performance range from 4 to 8 weeks in duration (Hoffman et al 2018), which may not be practical for use in military personnel with short notice before a mission. A recent investigation by Church et al (2017) demonstrated that a 2 week supplement duration of 12 g/day of BA increased intramuscular carnosine content to the same extent as 6 g/day taken for 4 weeks. In addition, the greater supplement dose was not associated with any greater risk for adverse effects (Church et al 2017).…”

Section: Introductionmentioning

confidence: 96%

“…A recent investigation by Church et al (2017) demonstrated that a 2 week supplement duration of 12 g/day of BA increased intramuscular carnosine content to the same extent as 6 g/day taken for 4 weeks. In addition, the greater supplement dose was not associated with any greater risk for adverse effects (Church et al 2017). Therefore, the purpose of this investigation was to examine the effects of 2 weeks of BA supplementation on physical performance, cognitive function, inflammation, and mood during a 24 h simulated SUSOP.…”

Section: Introductionmentioning

confidence: 96%

“…In addition, the greater supplement dose was not associated with any greater risk for adverse effects (Church et al. ). Therefore, the purpose of this investigation was to examine the effects of 2 weeks of BA supplementation on physical performance, cognitive function, inflammation, and mood during a 24 h simulated SUSOP.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of β-alanine supplementation on physical performance, cognition, endocrine function, and inflammation during a 24 h simulated military operation

et al. 2018

Self Cite

View full text Add to dashboard Cite

Sustained military operations (SUSOPs) are associated with performance decrements and cognitive dysfunction. β‐Alanine (BA) supplementation may have a role in increasing soldier resiliency by enhancing muscle‐buffering capacity and reducing oxidative stress. The purpose of this study was to examine the effects of BA on physical performance, cognition, endocrine function, and inflammation during a 24 h simulated SUSOP. Nineteen males were randomized into one of two groups: BA (n = 10) or placebo (n = 9; PLA) (12 g/day) for 14 days preceding the 24 h SUSOP. Assessments were performed at 0 h (0H), 12 h (12H), and 24 h (24H) during the SUSOP. No changes in visual tracking ability, jump power, or upper‐body muscular endurance were observed between groups or time points (P's > 0.05). Increases in subjective feelings of soreness and fatigue were noted at 12H compared to 0H (P < 0.05) in PLA, but not in BA. Visual reaction time for PLA was slower at 24H compared to 0H (P = 0.035), and PLA made more errors on reaction time testing at 12H compared to BA (P = 0.048), but motor reaction time was faster (P = 0.016) for PLA. Simulated litter carry and 1 km run completion times increased at 24H compared to 0H in both groups (P < 0.05), however, PLA had a longer 1 km time compared to BA at 24H (P = 0.050). Increases in inflammatory and endocrine markers were observed over the SUSOP, with no differences between groups. BA supplementation appears to maintain some aspects of cognition and physical performance during a 24 h SUSOP, with no effects on endocrine function or inflammation.

show abstract

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of β-alanine supplementation on physical performance, cognition, endocrine function, and inflammation during a 24 h simulated military operation

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Three-level mixed effects models were used to quantify the effects of supplementation dose. Insufficient data were available to allow investigation of the interaction between daily dose and intervention duration and so the total cumulative dose ingested was selected as the primary outcome, which previous research has identified as being more influential than either daily dose or intervention duration [16,19,20]. Subset analyses using study covariates were used to assess the effects of sex, age or measurement method on the main effect of BA supplementation.…”

Section: Methodsmentioning

confidence: 99%

Human Skeletal Muscle has Large Capacity to Increase Carnosine Content in Response to Beta-Alanine Supplementation. A Systematic Review with Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis

Rezende

Swinton

Oliveira

et al. 2019

Preprint

View full text Add to dashboard Cite

34Beta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and is ergogenic in many situations. Currently, many questions on the 35 nature of the Mcarn response to supplementation are open, and the response to these has considerable potential to enhance the efficacy and applications 36 of this supplementation strategy. Objective: To conduct a Bayesian analysis of available data on the Mcarn response to BA supplementation. Methods: A 37 systematic review with meta-analysis of individual and published aggregate data using a dose response (Emax) model was conducted. The protocol was 38 designed according to PRISMA guidelines. A three-step screening strategy was undertaken to identify studies that measured the Mcarn response to BA 39 supplementation. In addition, individual data from 5 separate studies conducted in the authors' laboratory were analysed. Data were extracted from all 40 controlled and uncontrolled supplementation studies conducted on healthy humans. Meta-regression was used to consider the influence of potential 41 moderators (including dose, sex, age, baseline Mcarn and analysis method used) on the primary outcome. Results and Conclusion: The Emax model 42 indicated that human skeletal muscle has large capacity for non-linear Mcarn accumulation, and that commonly used BA supplementation protocols may 43 not come close to saturating muscle carnosine content. Neither baseline values, nor sex, appear to influence subsequent response to supplementation. 44 Analysis of individual data indicated that Mcarn is relatively stable in the absence of intervention, and effectually all participants respond to BA 45 supplementation (99.3% response [95%CrI: 96.2 -100]).46 47

show abstract

Supplementation and Ergogenic Aids for Enhancing Muscular Strength Production

Domínguez

Naderi

Sánchez-Oliver

2021

Resistance Training Methods

View full text Add to dashboard Cite

Comparison of Two β-Alanine Dosing Protocols on Muscle Carnosine Elevations

Abstract: Results of this investigation indicate that a BA supplementation protocol of 12 g/d, using a sustained-release formulation, can accelerate the increase in carnosine content in skeletal muscle while attenuating paresthesia.

Cited by 41 publications

References 32 publications

Effects of β-alanine supplementation on physical performance, cognition, endocrine function, and inflammation during a 24 h simulated military operation

Effects of β-alanine supplementation on physical performance, cognition, endocrine function, and inflammation during a 24 h simulated military operation

Human Skeletal Muscle has Large Capacity to Increase Carnosine Content in Response to Beta-Alanine Supplementation. A Systematic Review with Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis

Supplementation and Ergogenic Aids for Enhancing Muscular Strength Production

Contact Info

Product

Resources

About