Comparison of umbilical cord ghrelin concentrations in full-term pregnant women with or without gestational diabetes

Karakulak, Murat; Saygılı, Uğur; Temür, Muzaffer; Yılmaz, Özgür; Özbay, Pelin Özün; Çalan, Mehmet; Cosar, Hese

doi:10.1080/07435800.2016.1194855

Cited by 6 publications

(8 citation statements)

References 40 publications

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“…Hehir et al [35] did not detect a significant difference between healthy and type 1 diabetic pregnant women in this respect. However, Karakulak et al [36] found that the umbilical cord blood ghrelin levels were decreased in the offspring of the gestational diabetes mellitus (GDM) women even after adjustment for birth weight, whereas Kara et al [20] were able to notice similar ghrelin and leptin concentrations in the serum of the control and GDM mothers’ newborns. It has been suggested that ghrelin may play a role in the fetal adaptation to intrauterine malnutrition [34].…”

Section: Discussionmentioning

confidence: 99%

Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring

Patro-Małysza

Trojnar

Skórzyńska-Dziduszko

et al. 2019

IJMS

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Two-thirds of pregnant women exceed gestational weight gain recommendations. Excessive gestational weight gain (EGWG) appears to be associated with offspring’s complications induced by mechanisms that are still unclear. The aim of this study was to investigate whether umbilical cord leptin (UCL) and ghrelin (UCG) concentrations are altered in full-term neonates born to EGWG mothers and whether neonatal anthropometric measurements correlate with UCL and UCG levels and maternal serum ghrelin and leptin as well as urine ghrelin concentrations. The study subjects were divided into two groups, 28 healthy controls and 38 patients with EGWG. Lower UCL and UCG levels were observed in neonates born to healthy mothers but only in male newborns. In the control group UCG concentrations correlated positively with neonatal birth weight, body length and head circumference. In the control group maternal serum ghrelin levels correlated negatively with neonatal birth weight, body length and head circumference as well as positively with chest circumference. In the EGWG group UCG concentrations correlated negatively with neonatal birth weight and birth body length. UCL correlated positively with birth body length in EGWG group and negatively with head circumference in the control group. In conclusion, EGWG is associated with disturbances in UCL and UCG concentrations.

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Section: Discussionmentioning

confidence: 99%

Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring

Patro-Małysza

Trojnar

Skórzyńska-Dziduszko

et al. 2019

IJMS

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“…Increased levels of ghrelin expression in term placentae were found in GDM compared to non-diabetic mothers [86,87]. Fetal ghrelin levels were inversely associated with neonatal birthweight [88]. Farquar et al found that the umbilical cord levels of ghrelin were inversely related to birth weight z-score (adiposity) and to cord blood glucose [89].…”

Section: Blood Levels Of Ghrelin and Fetal Growthmentioning

confidence: 99%

Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review

Ornoy

Becker

Weinstein-Fudim³

et al. 2021

IJMS

178

101

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In spite of the huge progress in the treatment of diabetes mellitus, we are still in the situation that both pregestational (PGDM) and gestational diabetes (GDM) impose an additional risk to the embryo, fetus, and course of pregnancy. PGDM may increase the rate of congenital malformations, especially cardiac, nervous system, musculoskeletal system, and limbs. PGDM may interfere with fetal growth, often causing macrosomia, but in the presence of severe maternal complications, especially nephropathy, it may inhibit fetal growth. PGDM may also induce a variety of perinatal complications such as stillbirth and perinatal death, cardiomyopathy, respiratory morbidity, and perinatal asphyxia. GDM that generally develops in the second half of pregnancy induces similar but generally less severe complications. Their severity is higher with earlier onset of GDM and inversely correlated with the degree of glycemic control. Early initiation of GDM might even cause some increase in the rate of congenital malformations. Both PGDM and GDM may cause various motor and behavioral neurodevelopmental problems, including an increased incidence of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Most complications are reduced in incidence and severity with the improvement in diabetic control. Mechanisms of diabetic-induced damage in pregnancy are related to maternal and fetal hyperglycemia, enhanced oxidative stress, epigenetic changes, and other, less defined, pathogenic mechanisms.

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“…The decreased umbilical cord ghrelin levels have been observed in women with GDM. The negative correlation between cord blood ghrelin concentration and birth weight was also found [30]. It has been revealed that fasting plasma glucose during pregnancy and in puerperium, and post--partum C-peptide and ghrelin levels were significant risk factors for the development of type 2 diabetes in women with previous GDM.…”

Section: Ghrelinmentioning

confidence: 77%

The role of new adipokines in gestational diabetes mellitus pathogenesis

Mierzyński

Poniedziałek‐Czajkowska

Dłuski

et al. 2018

Ginekol Pol

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Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition dur-ing pregnancy. Explanation of the GDM pathogenesis is important due to preventing gestational complications. During pregnancy there are significant changes in maternal metabolism. Many of these changes are influenced by different adi-pokines produced in the placenta and adipose tissue. The exact role of adipokines in the pathogenesis of GDM remains still unknown. Several adipokines have been analysed throughout gestation and their levels have been suggested as biomarkers of maternal-perinatal outcomes. Some of them have been postulated as significant in the pathogenesis of pregnancy complications like GDM. This report aims to review some of the recent topics of adipokine research that may be of particular importance in patho-physiology and diagnosis of gestational diabetes mellitus. Because of manuscript length limitations, after thorough literature review and in view of the recent evidence, we focus on the one of the most well-known adipokine: adiponectin, and not so well-studied: nesfatin-1, chemerin, ghrelin, and CTRP 1.

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Comparison of umbilical cord ghrelin concentrations in full-term pregnant women with or without gestational diabetes

Abstract: Umbilical ghrelin levels were lower in GDM women. Birth weight was inversely associated with umbilical ghrelin levels. This association may be explained by a negative feedback mechanism between ghrelin and birth weight.

Cited by 6 publications

References 40 publications

Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring

Leptin and Ghrelin in Excessive Gestational Weight Gain—Association between Mothers and Offspring

Diabetes during Pregnancy: A Maternal Disease Complicating the Course of Pregnancy with Long-Term Deleterious Effects on the Offspring. A Clinical Review

The role of new adipokines in gestational diabetes mellitus pathogenesis

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