Comparison of Urinary Alzheimer-Associated Neural Thread Protein (AD7c-NTP) Levels Between Patients With Amnestic and Nonamnestic Mild Cognitive Impairment

Abstract

Urinary Alzheimer-associated neural thread protein (AD7c-NTP) is a potential biomarker of Alzheimer disease (AD) or mild cognitive impairment (MCI). It is still unclear whether the urinary levels of AD7c-NTP are different between patients with amnestic MCI (aMCI) and nonamnestic MCI (naMCI). The present study aimed to explore the differences in urinary levels of AD7c-NTP between patients with aMCI and naMCI. Forty-six patients with MCI were divided into aMCI group (n = 23) and naMCI group (n = 23). The mean level of urinary AD7c-NTP in the aMCI group (32.75 ± 10.0 µg/mL) was significantly higher than that in the naMCI group (25.34 ± 9.0 µg/mL; P = .011). As far as we know, the present study is the first to show that individuals with aMCI have higher levels of urinary AD7c-NTP than those with naMCI, suggesting that urinary AD7c-NTP may be a potential biomarker to help identify patients with aMCI and naMCI.

Advances in the development paradigm of biosample‐based biosensors for early ultrasensitive detection of alzheimer’s disease

“…For this purpose, a microtiter plate was coated with a bispecific receptor antibody having high affinities for rabbit immunoglobulin G (IgG) and AD7c-NTP. Using this kit, the mean AD7c-NTP level in MCI patients was measured to be 32.76 ± 9 µg/mL [ 181 ]. Figure 6 shows a highly sensitive electrochemical biosensor electrode probe fabricated with a potential cycling electro-polymerization of poly(neutral red) (PNR) film modified with Fe 2 O 3 magnetic nanoparticles immobilized on acetylcholinesterase (AchE) using glutaraldehyde cross-linking.…”

Recent Evidence in Epigenomics and Proteomics Biomarkers for Early and Minimally Invasive Diagnosis of Alzheimer’s and Parkinson’s Diseases

“…In addition, α-synuclein and DJ-1 were found to be elevated in PD patients [ 147 , 148 ]. Also, Alzheimer-associated neuronal thread protein has been postulated as a good biomarker for AD and MCI in urine samples [ 149 , 150 ], as well as MCP-1 [ 151 ]. Moreover, tears could be a promising sample to study neurodegenerative diseases [ 83 ].…”

The fluid biomarkers of Alzheimer’s disease

“…In a pilot study, a targeted and quantitative metabolomics approach is applied, and several panels composed of urinary metabolites are identified to distinguish MCI and AD from cognitively healthy controls with high sensitivity and specificity [102]. Several novel urinary biomarkers for the early diagnosis of AD have been discovered, and some of them are Alzheimer-associated neuronal thread protein (AD7c-NTP) [103][104][105][106], monocyte chemoattractant protein-1 (MCP-1) [107], and dysregulated arginine metabolism [108].…”