Comparison of urinary and recombinant human chorionic gonadotropin during ovulation induction in intrauterine insemination cycles: a prospective randomized clinical trial

Comparing the efficacy of urinary and recombinant hCG on oocyte/follicle ratio to trigger ovulation in women undergoing intracytoplasmic sperm injection cycles: a randomized controlled trial

“…Our findings confirm the data from a previous Open-label RCT which the number of retrieved oocytes was comparable between 10,000 IU uhCG, 250 μg rhCG and 500 μg rhCG [7]. Several other studies showed similar results in comparison of urinary and recombinant hCG [6,8,10,11,25]. Moreover, Al-Inany et al in a systematic review concluded that in selecting the type of hCG for trigger of ovulation, additional factors such as safety, cost and drug availability should be considered [26].…”

“…In clinical practice, several trials have been performed to compare safety and efficacy of urinary and recombinant hCG preparations with different points of views. Some randomized trials have found equal efficiency with these two preparations [8,10,11] whereas some others have observed better outcomes in women who received rhCG [12,13]. On the other hand, based on a systematic review on 11 studies, uhCG has been stated as the best option for ovulation induction in ART [14].…”

Intrauterine insemination with recombinant or urinary human chorionic gonadotropin: A prospective randomized trial

“…Overall in these studies, no differences have been found between the two drugs with regard to the number of oocytes retrieved and pregnancy rate. Moreover, the dose of 250 mg rhCG has been shown to provide the optimal dose for final follicular maturation in treatment cycles for IVF/ICSI, as well as for timed intercourse and IUI [7][8][9].…”

“…The conclusion is that 250 mg rhCG corresponds to *5000 IU uhCG [5]. Pre-clinical studies in monkeys and rats have demonstrated the safety of rhCG (Ares-Serono International, data on file), and large multi-center trials involving normo-ovulatory women undergoing in vitro fertilization (IVF) programs have confirmed these data, showing high levels of tolerance and a pharmacokinetic profile comparable with that of uhCG [6][7][8].…”

“…Many studies [6,9,10] have been carried out to compare uhCG and rhCG in IVF cycles, whereas few studies [7,8] have been performed using the two treatments either in timed intercourse or intrauterine insemination (IUI). Overall, these studies have concluded that there is no evidence of a difference in clinical outcomes between urinary and recombinant products used for induction of final follicular maturation.…”