Comparison of urinary protein creatinine index in normal and heavy exercise performing individuals

Abstract

Background: Physical exercise is the performance of some activity in order to develop or maintain physical fitness and overall health. Exercise induce proteinuria is generally benign and a function of the intensity-rather than the duration of the exercise. Quantification using a 24 hours urine collection for protein is being replaced by the urine protein creatinine ration from a random urine specimen, ideally from the first morning void. Aims & Objective: To compare protein creatinine index between normal and heavy exercise performing individual. Materials and Methods: Total 40 controls (who were not doing exercise) and 34 subjects) who were doing heavy exercise daily) were selected for the study. Their early morning urine sample was taken for estimating urinary protein by quantitative sulfosalycylic acid method and creatinine by Jaffe's method using colorimetry. Results: The normal range of the PCI which was stabilized in this study was 62-220. On comparison of the PCI between the control and the subject, it was found to be significantly elevated in the person who does heavy exercise (controls = 114.64 ± 47.96 and in the person who does heavy exercise = 326.98 ± 117.99) (p<0.0001). Conclusion: The PCI of a random urine sample can provide a very useful, simple and convenient method for the quantitative assessment of proteinuria to judge the extent of kidney damage and for avoiding the drawback of the 24 hr urine collections.