Comparison of Urine Albumin-to-Creatinine Ratio (ACR) Between ACR Strip Test and Quantitative Test in Prediabetes and Diabetes

Nah, Eun‐Hee; Cho, Seon; Kim, Su‐Young; Cho, Han Ik

doi:10.3343/alm.2017.37.1.28

Cited by 39 publications

(34 citation statements)

References 23 publications

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“…However, there were several studies to evaluate the diagnostic performance of spot urine for the detection of MAU, since 24-hour urine collection is time and cost consuming. They showed that spot urine was a reliable measure of proteinuria in various subjects with diabetes, prediabetes, chronic kidney disease and rheumatic disease as well as in general population 25 – 31 . Third, MAU could transiently develop in the presence of inflammation or stress.…”

Section: Discussionmentioning

confidence: 99%

Microalbuminuria as a simple predictor of incident diabetes over 8 years in the Korean Genome and Epidemiology Study (KoGES)

Jung¹,

Byun²,

Kwon³

et al. 2017

Sci Rep

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Microalbuminuria (MAU) is a common subclinical disease and related with cardiovascular outcome both in diabetic and non-diabetic patients. However, there is rare data about the effect of MAU on the development of diabetes. Thus, we aimed to investigate whether MAU is associated with the development of incident diabetes. A total of 3385 subjects without diabetes (1503 men and 1882 women; mean age, 53 years) who participated in the Ansung–Ansan cohort study from 2001–2002 (baseline) to 2011–2012 (fifth follow-up visit) were followed for a mean of 8 years. The prevalence of MAU at baseline was 10.8% (365 patients), and the incidence of newly developed diabetes during the follow-up period was 15.3% (56 patients) in subjects with MAU. The hazard ratio (HR) for development of diabetes was 1.43 (95% confidence interval (CI) 1.07–1.91, p-value 0.016), independent of traditional risk factors for diabetes including pre-diabetes, age, obesity, and family history. The impact of MAU on diabetes was also significant in the non-pre-diabetic population (HR 2.08, 95% CI 1.07–4.03, p-value 0.031). In conclusion, our results show that incident MAU is associated with future development of diabetes and could be an early marker for diabetes, even in the non-prediabetic population.

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Section: Discussionmentioning

confidence: 99%

Microalbuminuria as a simple predictor of incident diabetes over 8 years in the Korean Genome and Epidemiology Study (KoGES)

Jung¹,

Byun²,

Kwon³

et al. 2017

Sci Rep

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“…while those with values of <30 mg/g were considered "negative (12). Reference range of serum creatinine used in this study was (0.6-1.2 mg/dl), serum magnesium (1.6-2.6 mg/dl).…”

Section: Reference Values Of Measured Investigationmentioning

confidence: 99%

Hypomagnesemia As A Marker Of Diabetic Nephropathy

Mashahit

Hammad

Shafie

et al. 2018

Fayoum University Medical journal

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Magnesium is an essential element and has a fundamental role in carbohydrate metabolism in general and in the insulin action in particular. Magnesium is involved in multiple levels in insulin secretion, binding and activity. Cellular magnesium deficiency can alter the activity of the membrane bound Na+K+ ATPase, which is involved in the maintenance of gradients of sodium and potassium and in glucose transport (1). Magnesium depletion has a negative impact on glucose homeostasis and insulin sensitivity in patients with type 2 diabetes as well as on the evolution of complications such as retinopathy, arterial atherosclerosis and nephropathy. Moreover, low serum magnesium is a strong, independent predictor of development of type 2 diabetes (2). A cross sectional study included 105 type 2 diabetic patients. Twenty nine were males (27.6%) and seventy six were females (72.4%).Their ages ranged from 30-77 with a mean of 49.7± 10.6. All patients were subjected to full clinical examination, and investigations which included: serum creatinine, HbA1c, albumin creatinine ratio and serum magnesium. Their mean BMI was 23 kg/m 2 and mean waist/hip ratio was 0.9.Their mean HbA1c was 8.55 %. Of all patients, 13 of them had normal level of A/C ratio (control group) and 92

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“…It is estimated that approximately one-third of the general population is affected by prediabetes ( 2 ). Prediabetes is associated with cardiovascular events ( 3 ) and complications such as nephropathy, ( 4 ) retinopathy, ( 5 ) and neuropathy ( 6 ). In addition, there is an increased risk of conversion to diabetes ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the longitudinal deformation of the left ventricular myocardium in subjects with impaired fasting glucose with and without increased glycated hemoglobin

Akhavan-Khaleghi¹,

Hosseinsabet

2018

Anatol J Cardiol

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ObjectivePrediabetes comprises a heterogeneous group because of the poor concordance of its definition. The aim of our study was to evaluate the longitudinal deformation of the left ventricular (LV) myocardium at the two opposite ends of the prediabetes spectrum as defined by fasting blood sugar and glycated hemoglobin (HbA1c).MethodsEighty consecutive subjects in a cross-sectional single-center study with impaired fasting glucose (IFG) (100–126 mg/dL) and without significant epicardial coronary artery stenosis seen on selective coronary angiography were included in our study and were divided into two groups based on their HbA1c levels (<5.7% and 5.7%–6.4%). The longitudinal deformation of the LV myocardium was compared between the two groups using two-dimensional speckle-tracking echocardiography (2DSTE).ResultsThe Student t-test, Mann–Whitney U test, or X2 test was used for data analysis, whichever was appropriate. The systolic strain (–16.1%±2.0 vs. –16.8%±2.4; p=0.214), systolic strain rate (–1.3±0.2 s–1 vs. –1.4±0.2 s–1; p=0.403), and early and late-diastolic strain rates (1.4±0.3 s–1 vs. 1.5±0.3 s–1; p=0.456 and 0.9±0.1 s–1 vs. 1.0±0.2 s–1; p=0.684, respectively) of the LV myocardium were not statistically different between the IFG subjects with and without increased HbA1c as detected using 2DSTE.ConclusionThe longitudinal deformation of the LV myocardium as detected using 2DSTE in the subjects without significant epicardial coronary artery stenosis was not statistically significantly different between the IFG subjects with and without increased HbA1c.

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Comparison of Urine Albumin-to-Creatinine Ratio (ACR) Between ACR Strip Test and Quantitative Test in Prediabetes and Diabetes

Cited by 39 publications

References 23 publications

Microalbuminuria as a simple predictor of incident diabetes over 8 years in the Korean Genome and Epidemiology Study (KoGES)

Microalbuminuria as a simple predictor of incident diabetes over 8 years in the Korean Genome and Epidemiology Study (KoGES)

Hypomagnesemia As A Marker Of Diabetic Nephropathy

Evaluation of the longitudinal deformation of the left ventricular myocardium in subjects with impaired fasting glucose with and without increased glycated hemoglobin

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