Comparison of usefulness of estradiol vaginal tablets and estriol vagitories for treatment of vaginal atrophy

Abstract

Estradiol vaginal tablets provides an effective alternative to traditional forms of local estrogen therapy.

Vaginal Estrogen Preparations: A Review of Safety and Efficacy for Vaginal Atrophy

“…It was then withheld for 7 days, and the cycle was repeated. Casper and Estradiol ring and estriol pessary equivalent responder rates for parameter of Petri, 1999 10 "symptoms of urogenital atrophy," including vaginal dryness, pruritis, dyspareunia, dysuria, and urinary urgency; further details not given Chompootaweep OCP and CEE cream equivalent et al, 1998 11 Dugal et al, 2000 12 Vaginal estradiol tablets superior to estriol vagitories Eriksen, 1992 13 Vaginal estradiol tablet superior to placebo Eriksen, 1999 14 Estradiol ring superior to no-treatment controls Henriksson et al, 1994 16 Estradiol ring and estriol pessary equivalent Lose Casper and Estradiol ring led to higher proportion of responders vs. placebo Petri, 1999 10 Chompootaweep OCP and CEE cream equivalent et al, 1998 11 Dugal et al, 2000 12 Vaginal estradiol tablets more efficious than estriol cream Eriksen, 1992 13 Vaginal estradiol tablet superior to placebo Eriksen, 1999 14 Estradiol ring superior to no-treatment controls Henriksson et al, 1994 16 Estradiol ring and estriol pessary equivalent Lose and Englev, Estradiol ring and estriol pessary equivalent 2000 3 Mattson et al, 1989 2 Both 25 and 50 mg estradiol pessary gave relief in all subjects Mettler and Olsen, Twice-weekly equivalent to once-weekly vaginal estradiol tablet 1991 5 Nachtigall, 1995 20 Estradiol ring and vaginal CEE cream equivalent Pruritis Barentsen et al, 1997 8 Estradiol ring more efficacious than estriol cream Bygdeman and Swahn, Dienestrol cream equivalent to nonhormonal vaginal lubricant 1996 1 Dugal et al, 2000 12 Vaginal estradiol tablets and estriol vagitories equivalent Eriksen, 1999 14 Estradiol ring and estriol pessary equivalent Henriksson et al, 1994 16 No difference in change between estradiol ring and no-treatment controls Mattson et al, 1989 2 Estradiol ring and estriol pessary equivalent Both 25 and 50 mg estradiol pessary gave relief in all subjects Irritation or burning Bygdeman and Swahn, Dienestrol cream equivalent to nonhormonal vaginal lubricant 1996 1 Dugal et al, 2000 12 Vaginal estradiol tablets and estriol vagitories equivalent Mettler and Olsen, Twice-weekly superior to once-weekly vaginal estradiol tablet 1991 5 Nachtigall, 1995 20 Estradiol ring and vaginal CEE cream equivalent Rioux et al, 2000 23 Estradiol vaginal tablet equivalent to ...…”

“…Only a few studies reported on dysuria (Table 3). Vaginal estradiol tablets and estriol vagitories failed to improve dysuria, 12 but other studies found the estradiol ring and the estriol pessary equally relieved dysuria. 3,16 One study found no difference in change from baseline in dysuria between no treatment and the use of an estradiol ring.…”

Urogenitale Beschwerden und Östradioltherapie

“…Entspre chend betrug der Zeitabstand zur Menopau se im untersuchten Patientenkollektiv im Mittel [15] und dass die Ak zeptanz dieser Applikationsform im Ver gleich zu Scheidenzäpfchen höher ist [16].…”

Nutzen und Risiko der Hormonersatztherapie – ein Update

“…Hier scheint eine vaginale Applikation günstige therapeutische Effekte zu erzielen [18] . Bezüglich einer oralen HRT bestehen unterschiedliche Ergebnisse: Brown et al [19] zeigten, dass eine orale HRT nicht zu einer Reduktion von Harnwegsinfektionen bei postmenopausalen Patientinnen zwischen 44 und 79 Jahren führt.…”