Comparison of Usefulness of Heart-Type Fatty Acid Binding Protein Versus Cardiac Troponin T for Diagnosis of Acute Myocardial Infarction

Haltern, Georg; Peiniger, Sigune; Bufe, Alexander; Reiss, G; Gülker, H; Scheffold, Thomas

doi:10.1016/j.amjcard.2009.08.645

Cited by 64 publications

(43 citation statements)

References 23 publications

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“…Basic and clinical research in rats and human autopsy cases revealed that H-FABP leakage occurred despite the absence of myocyte necrosis [24]. H-FABP is a low-molecular-weight protein that is confined to the cytoplasm and released into the circulation through the porous membranes of damaged myocardial cells [10,11].…”

Section: Discussionmentioning

confidence: 99%

Circulating heart-type fatty acid-binding protein levels predict ventricular fibrillation in Brugada syndrome

Daidoji

Arimoto

Iwayama

et al. 2016

Journal of Cardiology

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Section: Discussionmentioning

confidence: 99%

Circulating heart-type fatty acid-binding protein levels predict ventricular fibrillation in Brugada syndrome

Daidoji

Arimoto

Iwayama

et al. 2016

Journal of Cardiology

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“…Since hFABP plasma levels decrease fast by renal clearance, this is responsible for the differences in the plasma elimination rates as cardiac troponins are known to remain elevated for longer periods of time (5,17). It indicates the need for proper timing when sampling hFABP and indicates why hsTnI is more sensitive as a late marker for ischemia when hFABP is no longer detectable.…”

Section: H1106 Hfabp For Acute Myocardial Infarct Size and No-reflowmentioning

confidence: 96%

Serial measurement of hFABP and high-sensitivity troponin I post-PCI in STEMI: how fast and accurate can myocardial infarct size and no-reflow be predicted?

Uitterdijk

Sneep

Duin

et al. 2013

American Journal of Physiology-Heart and Circulatory Physiology

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The objective of this study was to compare heart-specific fatty acid binding protein (hFABP) and high-sensitivity troponin I (hsTnI) via serial measurements to identify early time points to accurately quantify infarct size and no-reflow in a preclinical swine model of ST-elevated myocardial infarction (STEMI). Myocardial necrosis, usually confirmed by hsTnI or TnT, takes several hours of ischemia before plasma levels rise in the absence of reperfusion. We evaluated the fast marker hFABP compared with hsTnI to estimate infarct size and no-reflow upon reperfused (2 h occlusion) and nonreperfused (8 h occlusion) STEMI in swine. In STEMI (n = 4) and STEMI + reperfusion (n = 8) induced in swine, serial blood samples were taken for hFABP and hsTnI and compared with triphenyl tetrazolium chloride and thioflavin-S staining for infarct size and no-reflow at the time of euthanasia. hFABP increased faster than hsTnI upon occlusion (82 ± 29 vs. 180 ± 73 min, P < 0.05) and increased immediately upon reperfusion while hsTnI release was delayed 16 ± 3 min (P < 0.05). Peak hFABP and hsTnI reperfusion values were reached at 30 ± 5 and 139 ± 21 min, respectively (P < 0.05). Infarct size (containing 84 ± 0.6% no-reflow) correlated well with area under the curve for hFABP (r(2) = 0.92) but less for hsTnI (r(2) = 0.53). At 50 and 60 min reperfusion, hFABP correlated best with infarct size (r(2) = 0.94 and 0.93) and no-reflow (r(2) = 0.96 and 0.94) and showed high sensitivity for myocardial necrosis (2.3 ± 0.6 and 0.4 ± 0.6 g). hFABP rises faster and correlates better with infarct size and no-reflow than hsTnI in STEMI + reperfusion when measured early after reperfusion. The highest sensitivity detecting myocardial necrosis, 0.4 ± 0.6 g at 60 min postreperfusion, provides an accurate and early measurement of infarct size and no-reflow.

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“…In addition, H-FABP predicts long-term mortality and re-infarction in patients with suspected ACS who are cTnT negative [5]. It has been suggested that the combination of H-FABP and cTnT would provide an optimal sensitivity and negative predictive value for ACS detection [3,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Heart-type fatty acid-binding protein (H-FABP) is established to be the earliest available plasma marker for ACS detection [2]. For triaging at presentation of patients suspected of ACS, H-FABP performs better than cardiac troponin T (cTnT) [3], and in the early hours after onset of symptoms even better than high-sensitivity cTnT [4]. In addition, H-FABP predicts long-term mortality and re-infarction in patients with suspected ACS who are cTnT negative [5].…”

Section: Introductionmentioning

confidence: 99%

Plasma reference value of heart-type fatty acid-binding protein, the earliest available plasma biomarker of acute myocardial infarction

Glatz¹,

Mohren²

2013

Health

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More rapid triaging of patients suspected for acute myocardial infarction (AMI) is needed to facilitate early initiation of appropriate therapy in patients with AMI and to exclude low-risk patients who can safely be sent home. Heart-type fatty acid-binding protein (H-FABP) is established to be the earliest available plasma marker for AMI diagnosis. There is a paucity of data on circulating levels of H-FABP in the general population. In this study we applied a H-FABP immunoassay with improved analytical performance to assess plasma H-FABP reference values in a relatively large group (n = 443) of healthy subjects aged 18 -69 y. Mean (±SD) plasma H-FABP concentration was 1.7 ± 0.9 ng/mL, with somewhat higher values found in males than in females. Plasma H-FABP also increases with age, as previously reported. The 99th centile was obtained for subjects aged 41 -69 years and amounted to 5.6 ng/mL.

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Comparison of Usefulness of Heart-Type Fatty Acid Binding Protein Versus Cardiac Troponin T for Diagnosis of Acute Myocardial Infarction

Cited by 64 publications

References 23 publications

Circulating heart-type fatty acid-binding protein levels predict ventricular fibrillation in Brugada syndrome

Circulating heart-type fatty acid-binding protein levels predict ventricular fibrillation in Brugada syndrome

Serial measurement of hFABP and high-sensitivity troponin I post-PCI in STEMI: how fast and accurate can myocardial infarct size and no-reflow be predicted?

Plasma reference value of heart-type fatty acid-binding protein, the earliest available plasma biomarker of acute myocardial infarction

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