Comparison of Usefulness of Left Ventricular Diastolic Versus Systolic Function as a Predictor of Outcome Following Primary Percutaneous Coronary Angioplasty for Acute Myocardial Infarction

Naqvi, Tasneem Z.; Padmanabhan, Sriram; Rafii, Farhad; Hyuhn, Hahn K.; Mirocha, James

doi:10.1016/j.amjcard.2005.08.022

Cited by 50 publications

(37 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In previous studies, both variables demonstrated to be of clinical importance (10,11). In the present study, the influence of these variables on LV remodeling was limited, and LV dyssynchrony at baseline appeared superior for prediction of LV remodeling.…”

Section: Discussioncontrasting

confidence: 64%

Left Ventricular Dyssynchrony Acutely After Myocardial Infarction Predicts Left Ventricular Remodeling

Mollema¹,

Liem²,

Suffoletto³

et al. 2007

Journal of the American College of Cardiology

110

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 64%

Left Ventricular Dyssynchrony Acutely After Myocardial Infarction Predicts Left Ventricular Remodeling

Mollema¹,

Liem²,

Suffoletto³

et al. 2007

Journal of the American College of Cardiology

110

View full text Add to dashboard Cite

show abstract

“…The sustained contraction that is seen in association with a reduced EF1 may represent a compensatory mechanism to maintain the overall EF, so that this is preserved even in the face of marked early systolic dysfunction. A link between early systolic and diastolic dysfunction mediated by a reverse of the shortening deactivation phenomenon would explain why E/E′ is prolonged after myocardial infarction and after angioplasty and is a good predictor of outcome after events such as these 25,26 that would not necessarily be expected to impact on diastolic relaxation per se.…”

Section: Discussionmentioning

confidence: 99%

Reduced First-Phase Ejection Fraction and Sustained Myocardial Wall Stress in Hypertensive Patients With Diastolic Dysfunction

Fok

et al. 2017

Hypertension

View full text Add to dashboard Cite

show abstract

“…The mitral inflow peak early velocity (E) to mitral annular peak early velocity (EЈ) (E/EЈ ratio) was assessed by dividing E by EЈ at the basal septal segment (22).…”

Section: Patients the Protocol Was Approved By The Local Medical Ethicsmentioning

confidence: 99%

Biventricular pacing in chronic heart failure acutely facilitates the arterial baroreflex

Gademan

Bommel²,

Ypenburg³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

View full text Add to dashboard Cite

Metabolic and mechanical stress in the failing heart activates the cardiac sympathetic afferent reflex (CSAR). It has been demonstrated that cardiac resynchronization therapy (CRT) acutely reduces MSNA in clinical responders. Mechanistically, this beneficial effect might be explained by acute deactivation of the CSAR. In addition to sympathoexcitation, CSAR inhibits the arterial baroreflex at the level of the nucleus tractus solitarii. Hence, in responders, CRT is likely to remove/reduce this inhibition. Therefore, we hypothesized that CRT acutely facilitates the arterial baroreflex. One day after implantation of a CRT device in 32 patients with chronic heart failure (LVEF; 27 +/- 6%), we measured noninvasive baroreflex sensitivity (BRS) and heart rate variability (HRV) in two conditions: CRT device switched on and switched off (on/off order randomized). BRS changes were correlated with the difference in unpaced/paced LVEF, a measure of acute mechanical response to CRT. CRT increased BRS by 35% from 2.96 to 3.79 ms/mmHg (P < 0.02) and increased HRV (standard deviation of the intervals between normal beats) from 18.5 to 24.0 ms (P < 0.01). The CRT-induced relative change in BRS correlated with the change in LVEF (r = 0.44; P < 0.01). In conclusion, CRT acutely increases BRS and HRV. This favorable response of the autonomic nervous system might be caused by CRT-induced CSAR deactivation. Follow-up studies should verify the mechanism of the acute response and the possible predictive value of an acute positive BRS response.

show abstract

Comparison of Usefulness of Left Ventricular Diastolic Versus Systolic Function as a Predictor of Outcome Following Primary Percutaneous Coronary Angioplasty for Acute Myocardial Infarction

Cited by 50 publications

References 23 publications

Left Ventricular Dyssynchrony Acutely After Myocardial Infarction Predicts Left Ventricular Remodeling

Left Ventricular Dyssynchrony Acutely After Myocardial Infarction Predicts Left Ventricular Remodeling

Reduced First-Phase Ejection Fraction and Sustained Myocardial Wall Stress in Hypertensive Patients With Diastolic Dysfunction

Biventricular pacing in chronic heart failure acutely facilitates the arterial baroreflex

Contact Info

Product

Resources

About