Comparison of Variables in Men Versus Women Undergoing Transcatheter Aortic Valve Implantation for Severe Aortic Stenosis (from Italian Multicenter CoreValve Registry)

Buja, Paolo; Napodano, Massimo; Tamburino, Corrado; Petronio, Anna Sonia; Ettori, Federica; Santoro, Gennaro; Ussia, Gian Paolo; Klugmann, Silvio; Bedogni, Francesco; Ramondo, Angelo; Maisano, Francesco; Marzocchi, Antonío; Poli, Arnaldo; Gasparetto, Valeria; Antoniucci, David; Colombo, Antonio; Tarantini, Giuseppe

doi:10.1016/j.amjcard.2012.08.051

Cited by 66 publications

(75 citation statements)

References 26 publications

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“…3,4 Several studies reported sex-specific incidence of complications and deaths after TAVI, but their results are inconsistent. Although some studies found no significant differences in 30-day mortality between men and women, 5,6 others, however, suggested a higher 30-day and 1-year mortality among the male population. 7,8 So, we performed a meta-analysis of published studies that reported sex-specific data on the incidence of post-TAVI complications and deaths, aiming at comprehensively and quantitatively reviewing all the available studies and providing effect estimates.…”

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confidence: 97%

“…Of the 27 full-length reports, only 5 detailed the baseline data of men and women separately. [5][6][7][8]26 The pooled sexspecific baseline characteristics based on these studies showed that men were more likely to experience diabetes mellitus, chronic obstructive pulmonary disease, coronary artery disease, previous myocardial infarction, previous percutaneous WhAT IS KNOWN …”

Section: Study and Patient Characteristicsmentioning

confidence: 99%

“…5,7,8,16,26,27 These studies enrolled 1403 men and 1459 women, and the overall incidence of major/ life-threatening bleeding was 12.8% and 15.3%, respectively. Men had a significantly lower risk for major/life-threatening bleeding (pooled RR, 0.81; 95% confidence interval [CI], 0.68-0.96; Figure 2).…”

Section: Sex Differences In Complications After Tavimentioning

confidence: 99%

“…A total of 27 full-text articles were eligible for our systematic review and meta-analysis. [5][6][7][8] These studies included 4176 men and 4942 women for the comparison of sex-related differences in complications and mortality after TAVI. Although the 2 studies overlapped in patient population, they provided different outcomes.…”

Section: Literature Search and Study Selectionmentioning

confidence: 99%

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Sex-Related Differences in Outcomes After Transcatheter Aortic Valve Implantation

Zhang

Liao

Peng

et al. 2013

Circ: Cardiovascular Interventions

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Studies were initially screened at the level of title and abstract, and then full-length reports were retrieved for detailed evaluation. Two authors independently selected articles according to prespecified inclusion and exclusion criteria. Articles were included if they (1) reported Background-There were considerable discrepancies with regard to sex-related differences in complications and prognosis after transcatheter aortic valve implantation. Methods and Results-The Cochrane library and PubMed online databases were searched. Articles reporting sex-specific post-transcatheter aortic valve implantation complications and mortality were identified. Two authors selected studies and extracted data independently. Random-and fixed-effects models were used depending on between-study heterogeneity. There were 27 articles, a total of 9118 patients, enrolled in our systematic review and meta-analysis, including 4176 men and 4942 women. Pooled analyses suggested considerable sex-related differences in complications and early as well as midterm outcomes after transcatheter aortic valve implantation. The difference in the risk for heart block requiring permanent pacemaker implantation was noted to be significant only in the subgroup of the CoreValve-dominating studies (pooled risk ratio [RR, men versus women], 1.29; 95% confidence interval [CI], 1.13-1.47). Although men had significantly lower risks for major/life-threatening bleeding (pooled RR, 0.81; 95% CI, 0.68-0.96) and major vascular complications (pooled RR, 0.49; 95% CI, 0.37-0.66), they had poorer prognosis. In fact, male sex was associated with significantly higher risks for deaths at both 30 days (RR, 1.37; 95% CI, 1.07-1.76) and 1 year (RR, 1.30; 95% CI, 1.14-1.49). Conclusions-Although men had lower risks for major/life-threatening bleeding and major vascular complications after transcatheter aortic valve implantation, they had less favorable short-term and midterm survival. (Circ Cardiovasc Interv. 2013;6:543-551.)

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confidence: 97%

Section: Study and Patient Characteristicsmentioning

confidence: 99%

Section: Sex Differences In Complications After Tavimentioning

confidence: 99%

Section: Literature Search and Study Selectionmentioning

confidence: 99%

See 2 more Smart Citations

Sex-Related Differences in Outcomes After Transcatheter Aortic Valve Implantation

Zhang

Liao

Peng

et al. 2013

Circ: Cardiovascular Interventions

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“…Differently from surgical series, women treated by TAVR were approximately 50% (4,6) and seems to have a significant survival advantage compared to the male patients (4,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The overall result of this pooled analysis of studies is shown in Figure 1.…”

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confidence: 74%